ENSG00000125170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340099 ENSG00000125170 HEK293_OSMI2_6hA HEK293_TMG_6hB DOK4 protein_coding protein_coding 5.913708 8.486698 2.701911 0.9378368 0.4106832 -1.647593 3.60345761 4.7339157 1.2339778 0.5225975 0.02934355 -1.931118 0.60166250 0.55960000 0.4760333 -0.08356667 0.76979346 0.01319539 FALSE TRUE
ENST00000566936 ENSG00000125170 HEK293_OSMI2_6hA HEK293_TMG_6hB DOK4 protein_coding protein_coding 5.913708 8.486698 2.701911 0.9378368 0.4106832 -1.647593 1.78358575 3.0136112 0.9789208 0.2361442 0.13406157 -1.612346 0.29375417 0.35833333 0.3847333 0.02640000 0.98964270 0.01319539 FALSE TRUE
ENST00000569250 ENSG00000125170 HEK293_OSMI2_6hA HEK293_TMG_6hB DOK4 protein_coding protein_coding 5.913708 8.486698 2.701911 0.9378368 0.4106832 -1.647593 0.06112649 0.0000000 0.4890119 0.0000000 0.48901189 5.641002 0.01740417 0.00000000 0.1392333 0.13923333 0.74035177 0.01319539 FALSE FALSE
MSTRG.12721.3 ENSG00000125170 HEK293_OSMI2_6hA HEK293_TMG_6hB DOK4 protein_coding   5.913708 8.486698 2.701911 0.9378368 0.4106832 -1.647593 0.27165240 0.4528516 0.0000000 0.1639380 0.00000000 -5.532478 0.05491667 0.05073333 0.0000000 -0.05073333 0.01319539 0.01319539 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000125170 E001 0.7794795 0.0171288389 0.881334017   16 57471922 57471960 39 - 0.231 0.202 -0.240
ENSG00000125170 E002 117.9016969 0.0086176928 0.781603865 0.8855921 16 57471961 57472731 771 - 1.943 1.957 0.046
ENSG00000125170 E003 42.3620945 0.0012041602 0.567689488 0.7485634 16 57472732 57472876 145 - 1.548 1.511 -0.127
ENSG00000125170 E004 114.1525095 0.0004230460 0.070167637 0.2251144 16 57472877 57473495 619 - 1.999 1.931 -0.231
ENSG00000125170 E005 16.3167131 0.0023572478 0.190740542 0.4178120 16 57473496 57473612 117 - 1.234 1.104 -0.460
ENSG00000125170 E006 45.7728026 0.0016265188 0.719117709 0.8476330 16 57473613 57473736 124 - 1.574 1.552 -0.073
ENSG00000125170 E007 53.8514422 0.0008171552 0.360288281 0.5959349 16 57473901 57474039 139 - 1.574 1.633 0.203
ENSG00000125170 E008 0.3751086 0.0268859475 1.000000000   16 57474712 57474792 81 - 0.000 0.113 9.802
ENSG00000125170 E009 46.2770088 0.0008468065 0.666158644 0.8138041 16 57474793 57474889 97 - 1.531 1.562 0.106
ENSG00000125170 E010 39.2937365 0.0010120660 0.184414480 0.4097197 16 57474890 57474982 93 - 1.407 1.509 0.350
ENSG00000125170 E011 26.3848134 0.0227846302 0.470290328 0.6802901 16 57475100 57475142 43 - 1.250 1.343 0.326
ENSG00000125170 E012 20.6409376 0.0157111826 0.753088200 0.8686024 16 57475143 57475160 18 - 1.195 1.238 0.152
ENSG00000125170 E013 18.1175684 0.0053233298 0.816864592 0.9063743 16 57475161 57475161 1 - 1.196 1.176 -0.070
ENSG00000125170 E014 18.6824273 0.0024167429 0.575282304 0.7538575 16 57475162 57475168 7 - 1.233 1.182 -0.182
ENSG00000125170 E015 16.6945191 0.0023936426 0.924224175 0.9644917 16 57475169 57475169 1 - 1.134 1.147 0.047
ENSG00000125170 E016 22.5635785 0.0015903789 0.310762308 0.5512192 16 57475170 57475198 29 - 1.177 1.277 0.356
ENSG00000125170 E017 20.4429510 0.0018503992 0.238175086 0.4745087 16 57475199 57475208 10 - 1.111 1.235 0.440
ENSG00000125170 E018 22.9557190 0.0019185305 0.136734535 0.3425029 16 57475209 57475219 11 - 1.134 1.284 0.532
ENSG00000125170 E019 23.2182631 0.0019653844 0.276698687 0.5167064 16 57475506 57475513 8 - 1.177 1.284 0.380
ENSG00000125170 E020 33.8371687 0.0016481484 0.178779951 0.4023488 16 57475514 57475558 45 - 1.329 1.440 0.386
ENSG00000125170 E021 26.7252568 0.0368202205 0.503480638 0.7032162 16 57475559 57475563 5 - 1.269 1.335 0.233
ENSG00000125170 E022 37.1127461 0.0037320484 0.401797858 0.6298590 16 57475564 57475620 57 - 1.407 1.474 0.229
ENSG00000125170 E023 29.9978186 0.0034989475 0.995720640 0.9994544 16 57475850 57475862 13 - 1.370 1.370 0.001
ENSG00000125170 E024 44.9783013 0.0011920053 0.032915552 0.1358367 16 57475863 57475957 95 - 1.648 1.515 -0.453
ENSG00000125170 E025 0.4054685 0.5902563392 1.000000000   16 57475958 57476310 353 - 0.000 0.120 8.971
ENSG00000125170 E026 0.6182515 0.0286037981 0.692805200   16 57478544 57478662 119 - 0.231 0.160 -0.654
ENSG00000125170 E027 45.3276811 0.0033668885 0.007463052 0.0468487 16 57479442 57479685 244 - 1.688 1.519 -0.577
ENSG00000125170 E028 4.5456989 0.0084690991 0.997218642 1.0000000 16 57479686 57479688 3 - 0.654 0.658 0.017
ENSG00000125170 E029 3.1012798 0.0073807930 0.854245419 0.9272111 16 57479689 57479844 156 - 0.492 0.528 0.175
ENSG00000125170 E030 0.2027342 0.0364745126 1.000000000   16 57479845 57479860 16 - 0.000 0.060 8.782
ENSG00000125170 E031 0.0000000       16 57479861 57479914 54 -      
ENSG00000125170 E032 0.0000000       16 57480295 57480329 35 -      
ENSG00000125170 E033 0.0000000       16 57480330 57480417 88 -      
ENSG00000125170 E034 0.0000000       16 57481462 57481853 392 -      
ENSG00000125170 E035 0.1308682 0.0326491905 1.000000000   16 57483958 57484294 337 - 0.000 0.060 8.797
ENSG00000125170 E036 4.1007495 0.0935116600 0.916709139 0.9605122 16 57486305 57486493 189 - 0.583 0.632 0.217
ENSG00000125170 E037 0.0000000       16 57487096 57487130 35 -      
ENSG00000125170 E038 0.0000000       16 57487131 57487245 115 -      
ENSG00000125170 E039 0.0000000       16 57487246 57487327 82 -