ENSG00000124920

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536352 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding retained_intron 1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.05105430 0.1564704 0.00000000 0.15647042 0.00000000 -4.0571940 0.02324583 0.05310000 0.00000000 -0.05310000 0.959349357 0.001780997 TRUE FALSE
ENST00000537318 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding retained_intron 1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.06105733 0.0000000 0.11482379 0.00000000 0.03983337 3.6418211 0.04468750 0.00000000 0.12316667 0.12316667 0.003123723 0.001780997 FALSE TRUE
ENST00000675319 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding protein_coding 1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.09599391 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05795417 0.00000000 0.00000000 0.00000000   0.001780997 FALSE TRUE
ENST00000675792 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding nonsense_mediated_decay 1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.28287619 0.4718508 0.22209050 0.07666125 0.06210394 -1.0538990 0.15535417 0.19450000 0.23343333 0.03893333 0.943641657 0.001780997 TRUE FALSE
MSTRG.5577.1 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding   1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.21429164 0.7120895 0.02281446 0.22621029 0.02281446 -4.4597740 0.12431667 0.29750000 0.02983333 -0.26766667 0.135759478 0.001780997 FALSE TRUE
MSTRG.5577.10 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding   1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.46230451 0.7640904 0.00000000 0.18295087 0.00000000 -6.2744302 0.24464583 0.32423333 0.00000000 -0.32423333 0.001780997 0.001780997 FALSE TRUE
MSTRG.5577.4 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding   1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.14619879 0.0000000 0.28222622 0.00000000 0.14416486 4.8690137 0.11016250 0.00000000 0.34150000 0.34150000 0.193432558 0.001780997 FALSE TRUE
MSTRG.5577.8 ENSG00000124920 HEK293_OSMI2_6hA HEK293_TMG_6hB MYRF protein_coding   1.737049 2.466658 0.9370309 0.2607259 0.1043351 -1.386911 0.14577305 0.1790098 0.15825801 0.17900983 0.15825801 -0.1677861 0.08496250 0.06073333 0.14066667 0.07993333 0.959006703 0.001780997 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000124920 E001 0.1308682 0.031426623 1.000000000   11 61752629 61752635 7 + 0.000 0.072 34.559
ENSG00000124920 E002 0.4756169 0.022337791 0.565004963   11 61752636 61752641 6 + 0.000 0.188 36.139
ENSG00000124920 E003 1.4881905 0.013696863 0.426576398 0.64849281 11 61752642 61752711 70 + 0.197 0.389 1.333
ENSG00000124920 E004 2.6547328 0.012954667 0.741746774 0.86151557 11 61752712 61752790 79 + 0.518 0.502 -0.079
ENSG00000124920 E005 0.0000000       11 61755389 61755442 54 +      
ENSG00000124920 E006 1.5709132 0.012945188 0.189099399 0.41583888 11 61765625 61765628 4 + 0.518 0.319 -1.082
ENSG00000124920 E007 2.7195320 0.008213210 0.190392592 0.41745130 11 61765629 61765712 84 + 0.648 0.476 -0.794
ENSG00000124920 E008 0.1723744 0.032374987 1.000000000   11 61765713 61765957 245 + 0.000 0.072 34.555
ENSG00000124920 E009 3.8326139 0.006386987 0.371356123 0.60502529 11 61765958 61766116 159 + 0.701 0.610 -0.389
ENSG00000124920 E010 2.4465816 0.030925965 0.815710070 0.90568024 11 61766117 61766221 105 + 0.435 0.523 0.438
ENSG00000124920 E011 1.3439059 0.352813737 0.283550561   11 61766222 61766867 646 + 0.436 0.286 -0.895
ENSG00000124920 E012 1.2627311 0.015671192 0.530216162   11 61769260 61769321 62 + 0.197 0.355 1.135
ENSG00000124920 E013 0.8098394 0.053486568 1.000000000   11 61770246 61770370 125 + 0.197 0.237 0.334
ENSG00000124920 E014 1.7614533 0.065414414 0.790340772 0.89075835 11 61770371 61770525 155 + 0.333 0.442 0.613
ENSG00000124920 E015 7.4402413 0.016038262 0.153662088 0.36754024 11 61771500 61771750 251 + 0.649 0.931 1.124
ENSG00000124920 E016 6.6608997 0.028853288 0.996870850 1.00000000 11 61771829 61771952 124 + 0.790 0.850 0.238
ENSG00000124920 E017 8.9602899 0.064355258 0.652263375 0.80488678 11 61773967 61774162 196 + 0.860 0.969 0.414
ENSG00000124920 E018 5.5515159 0.054464024 0.707216878 0.84004820 11 61776056 61776132 77 + 0.787 0.764 -0.093
ENSG00000124920 E019 7.2313097 0.009201425 0.161780970 0.37941404 11 61776322 61776432 111 + 0.957 0.831 -0.480
ENSG00000124920 E020 7.4208201 0.039059117 0.083769867 0.25231993 11 61776787 61776877 91 + 1.009 0.824 -0.700
ENSG00000124920 E021 8.0389287 0.004647054 0.291475042 0.53210034 11 61777264 61777464 201 + 0.957 0.885 -0.271
ENSG00000124920 E022 0.0000000       11 61777606 61777733 128 +      
ENSG00000124920 E023 5.8482137 0.007529037 0.747189081 0.86501964 11 61777734 61777845 112 + 0.701 0.807 0.427
ENSG00000124920 E024 3.2306179 0.008995887 0.819571608 0.90787194 11 61778380 61778429 50 + 0.519 0.609 0.413
ENSG00000124920 E025 3.3624637 0.009224938 0.694324663 0.83191319 11 61778430 61778489 60 + 0.589 0.570 -0.082
ENSG00000124920 E026 3.2237160 0.802943165 0.211031008 0.44299896 11 61778829 61779262 434 + 0.655 0.540 -0.510
ENSG00000124920 E027 9.7920597 0.003371174 0.355957110 0.59248004 11 61779263 61779423 161 + 1.009 0.961 -0.178
ENSG00000124920 E028 0.3807181 0.050542351 0.345101599   11 61779424 61779497 74 + 0.198 0.072 -1.667
ENSG00000124920 E029 5.0586405 0.006071298 0.931123227 0.96759396 11 61779498 61779558 61 + 0.701 0.741 0.165
ENSG00000124920 E030 3.6724157 0.006869032 0.310939894 0.55136465 11 61779559 61779570 12 + 0.435 0.664 1.067
ENSG00000124920 E031 8.1482216 0.004504013 0.648175791 0.80230972 11 61779842 61779930 89 + 0.898 0.896 -0.007
ENSG00000124920 E032 0.0000000       11 61780212 61780221 10 +      
ENSG00000124920 E033 5.9886742 0.006740638 0.777160128 0.88302566 11 61780222 61780290 69 + 0.701 0.796 0.385
ENSG00000124920 E034 0.4868358 0.410332461 0.160388398   11 61780712 61780792 81 + 0.338 0.071 -2.741
ENSG00000124920 E035 1.6674774 0.052292415 0.271154413 0.51115885 11 61780957 61780959 3 + 0.518 0.353 -0.874
ENSG00000124920 E036 6.2645824 0.031768496 0.908865739 0.95650589 11 61780960 61781045 86 + 0.748 0.819 0.279
ENSG00000124920 E037 12.2741645 0.003766684 0.296263261 0.53682503 11 61781138 61781329 192 + 1.097 1.046 -0.186
ENSG00000124920 E038 12.2180091 0.002693262 0.189199311 0.41596513 11 61781573 61781807 235 + 1.117 1.039 -0.281
ENSG00000124920 E039 3.8793543 0.021077256 0.698877504 0.83490774 11 61781808 61781824 17 + 0.648 0.629 -0.082
ENSG00000124920 E040 0.4820342 0.021832446 0.004588631   11 61781825 61781936 112 + 0.436 0.000 -39.513
ENSG00000124920 E041 5.1720960 0.042091752 0.009543227 0.05616174 11 61781937 61783497 1561 + 0.959 0.613 -1.382
ENSG00000124920 E042 0.8267151 0.238726275 0.320537369   11 61783498 61783512 15 + 0.000 0.308 37.065
ENSG00000124920 E043 6.8531348 0.026842541 0.311179264 0.55157603 11 61783513 61783600 88 + 0.649 0.868 0.887
ENSG00000124920 E044 8.3856258 0.015832883 0.514709185 0.71147316 11 61783851 61783925 75 + 0.791 0.943 0.587
ENSG00000124920 E045 1.1769534 0.015892240 0.205273978   11 61783926 61784027 102 + 0.436 0.237 -1.254
ENSG00000124920 E046 1.1359948 0.022583888 0.661746100   11 61784028 61784279 252 + 0.332 0.280 -0.342
ENSG00000124920 E047 10.5471257 0.003467538 0.356384778 0.59286079 11 61784280 61784385 106 + 0.865 1.039 0.651
ENSG00000124920 E048 4.2708903 0.541116507 0.322438592 0.56187463 11 61784386 61785510 1125 + 0.980 0.490 -2.031
ENSG00000124920 E049 1.5105558 0.012866695 0.408491776 0.63486694 11 61785713 61785799 87 + 0.436 0.319 -0.669
ENSG00000124920 E050 9.4868165 0.098595806 0.989621483 0.99654339 11 61785800 61785874 75 + 0.895 0.970 0.282
ENSG00000124920 E051 94.2484453 0.606906849 0.232129536 0.46766609 11 61786063 61788518 2456 + 1.670 1.961 0.982