ENSG00000123728

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342983 ENSG00000123728 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP2C protein_coding protein_coding 13.30227 6.017448 19.02309 1.490015 1.162339 1.658891 6.442500 2.861139 8.771770 0.8629553 0.6484066 1.6128886 0.4658208 0.4591333 0.4625000 0.003366667 1.000000e+00 2.34983e-12 FALSE TRUE
ENST00000460462 ENSG00000123728 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP2C protein_coding processed_transcript 13.30227 6.017448 19.02309 1.490015 1.162339 1.658891 2.480896 0.000000 4.052147 0.0000000 0.7312774 8.6660986 0.1252667 0.0000000 0.2118667 0.211866667 2.349830e-12 2.34983e-12 FALSE TRUE
ENST00000620646 ENSG00000123728 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP2C protein_coding protein_coding 13.30227 6.017448 19.02309 1.490015 1.162339 1.658891 3.614749 2.743548 5.301453 0.5899929 0.5351424 0.9478148 0.3552167 0.4679000 0.2807667 -0.187133333 1.471349e-01 2.34983e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000123728 E001 0.0000000       X 132203024 132203024 1 -      
ENSG00000123728 E002 37.0483214 0.2127791931 0.1693968246 0.389782084 X 132203025 132203249 225 - 1.400 1.765 1.248
ENSG00000123728 E003 247.8684514 1.0211483106 0.3593507329 0.595300299 X 132203250 132204299 1050 - 2.284 2.502 0.726
ENSG00000123728 E004 35.3822433 0.0690085970 0.2726114932 0.512466394 X 132204300 132204307 8 - 1.477 1.638 0.551
ENSG00000123728 E005 207.3711235 0.9530840327 0.3877943408 0.618759204 X 132204308 132205059 752 - 2.228 2.396 0.560
ENSG00000123728 E006 104.8277632 0.4672146976 0.3314218935 0.570307331 X 132205060 132205448 389 - 1.947 2.084 0.459
ENSG00000123728 E007 92.6937830 0.4476391631 0.5479410868 0.734847461 X 132205449 132205587 139 - 1.937 1.956 0.064
ENSG00000123728 E008 164.5698943 0.0772067860 0.0339251768 0.138653542 X 132214134 132214446 313 - 2.214 2.137 -0.257
ENSG00000123728 E009 82.9479642 0.0007651216 0.0004606309 0.005317499 X 132216996 132217141 146 - 1.924 1.875 -0.164
ENSG00000123728 E010 33.1492948 0.1254514081 0.8539379721 0.927078844 X 132217142 132217156 15 - 1.498 1.532 0.116
ENSG00000123728 E011 54.3475159 0.0063945730 0.0026234285 0.021111619 X 132217157 132217277 121 - 1.749 1.669 -0.272
ENSG00000123728 E012 48.3078917 0.1188035069 0.0728528212 0.230517126 X 132217278 132217367 90 - 1.692 1.602 -0.305
ENSG00000123728 E013 36.7806822 0.2717627148 0.2892126701 0.529741285 X 132217368 132217665 298 - 1.567 1.509 -0.200
ENSG00000123728 E014 11.5837466 0.3081747913 0.4237992913 0.646415658 X 132217666 132217756 91 - 0.891 1.311 1.521
ENSG00000123728 E015 11.6142941 0.2876304594 0.4572143871 0.671192127 X 132217757 132217806 50 - 0.903 1.302 1.445
ENSG00000123728 E016 10.5186378 0.3705545851 0.5886413857 0.762776001 X 132217916 132218012 97 - 0.885 1.244 1.308
ENSG00000123728 E017 4.0097605 0.2217917852 0.6047537783 0.773351663 X 132218013 132218231 219 - 0.560 0.867 1.276
ENSG00000123728 E018 0.4952057 0.2252468914 1.0000000000   X 132218232 132218333 102 - 0.158 0.170 0.118
ENSG00000123728 E019 0.0000000       X 132218334 132218341 8 -      
ENSG00000123728 E020 0.6494192 0.0193874923 0.6423833898   X 132218342 132218832 491 - 0.219 0.169 -0.467
ENSG00000123728 E021 1.4858756 0.2129694306 0.5508707688 0.736960687 X 132219370 132219480 111 - 0.318 0.521 1.102