ENSG00000123600

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000438609 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding protein_coding 11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 1.3437959 0.82377163 2.1322752 0.36548209 0.3961233 1.3614196 0.10043333 0.12806667 0.10803333 -0.020033333 0.98502002 0.02006581 FALSE TRUE
ENST00000442778 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding protein_coding 11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 0.5350396 0.00000000 2.2701846 0.00000000 1.2962078 7.8330068 0.02714583 0.00000000 0.11106667 0.111066667 0.45824736 0.02006581 FALSE FALSE
ENST00000447486 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding nonsense_mediated_decay 11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 0.8744010 0.46577195 1.6520624 0.20968851 0.3302941 1.8046324 0.07024583 0.07146667 0.08486667 0.013400000 0.94607040 0.02006581 TRUE TRUE
ENST00000453846 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding protein_coding 11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 0.8757506 0.29244041 0.9205276 0.16307988 0.1459226 1.6213980 0.06855833 0.05083333 0.04670000 -0.004133333 0.95370341 0.02006581 FALSE FALSE
ENST00000462821 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding processed_transcript 11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 0.6858709 0.71085754 1.8297772 0.37082286 1.3430677 1.3517450 0.05023750 0.12610000 0.08810000 -0.038000000 0.95307006 0.02006581 FALSE FALSE
ENST00000463392 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding processed_transcript 11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 1.3080138 0.20974965 2.4462800 0.20974965 1.3280896 3.4825423 0.14251667 0.04496667 0.11366667 0.068700000 0.74221234 0.02006581 FALSE FALSE
ENST00000612742 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding protein_coding 11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 1.7226920 1.11859795 1.7893755 0.39176340 0.4907151 0.6729647 0.18213750 0.17560000 0.09293333 -0.082666667 0.61566731 0.02006581 FALSE TRUE
MSTRG.19478.1 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding   11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 0.9083817 1.09314164 1.2065013 0.24582946 0.1780984 0.1411198 0.08882917 0.17693333 0.06116667 -0.115766667 0.02006581 0.02006581 TRUE TRUE
MSTRG.19478.3 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding   11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 0.7593694 0.34381832 1.1738233 0.34381832 1.1738233 1.7423731 0.07204167 0.05093333 0.06630000 0.015366667 0.94366337 0.02006581 TRUE TRUE
MSTRG.19478.5 ENSG00000123600 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL8 protein_coding   11.52371 6.009563 20.12911 0.6729214 1.311966 1.742269 0.6701107 0.04108222 1.9266235 0.04108222 1.0702099 5.2445784 0.03996667 0.00610000 0.08940000 0.083300000 0.65753297 0.02006581 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000123600 E001 2.7497042 0.0084265611 2.301607e-03 1.906198e-02 2 171244981 171245007 27 - 0.328 0.815 2.294
ENSG00000123600 E002 3.9169164 0.0062396031 5.027047e-05 8.358217e-04 2 171271219 171271342 124 - 0.372 0.968 2.615
ENSG00000123600 E003 1.4712625 0.0129142228 4.750548e-02 1.737857e-01 2 171298322 171298384 63 - 0.225 0.576 2.028
ENSG00000123600 E004 0.9456969 0.0159645745 1.353871e-02   2 171298385 171298435 51 - 0.088 0.519 3.348
ENSG00000123600 E005 0.4397201 0.0492042452 2.629455e-01   2 171298436 171298446 11 - 0.089 0.282 2.017
ENSG00000123600 E006 2.1960643 0.0114360637 2.368736e-02 1.081319e-01 2 171301012 171301026 15 - 0.328 0.711 1.874
ENSG00000123600 E007 4.9723383 0.0907008172 1.546710e-01 3.689504e-01 2 171301027 171301183 157 - 0.643 0.920 1.109
ENSG00000123600 E008 360.9836876 0.0013364022 9.477754e-11 6.757098e-09 2 171315746 171323250 7505 - 2.478 2.627 0.495
ENSG00000123600 E009 75.7511380 0.0048423628 9.990982e-01 1.000000e+00 2 171323251 171323787 537 - 1.856 1.869 0.043
ENSG00000123600 E010 24.2811435 0.0227462814 7.140702e-01 8.443735e-01 2 171323788 171323900 113 - 1.386 1.375 -0.040
ENSG00000123600 E011 10.7727299 0.0029305375 6.973000e-01 8.337962e-01 2 171323901 171323920 20 - 1.057 1.028 -0.103
ENSG00000123600 E012 12.5886620 0.0024795829 1.857823e-01 4.115888e-01 2 171323921 171323932 12 - 1.149 1.028 -0.437
ENSG00000123600 E013 26.8756707 0.0066944255 5.601265e-01 7.434222e-01 2 171323933 171323997 65 - 1.438 1.410 -0.099
ENSG00000123600 E014 24.1077782 0.0014795588 8.277128e-01 9.124719e-01 2 171323998 171324024 27 - 1.368 1.397 0.100
ENSG00000123600 E015 26.9949945 0.0015290944 7.754453e-01 8.820274e-01 2 171324025 171324043 19 - 1.427 1.421 -0.023
ENSG00000123600 E016 44.4958810 0.0075078930 8.614409e-01 9.311454e-01 2 171324044 171324100 57 - 1.629 1.649 0.068
ENSG00000123600 E017 74.9651130 0.0082958334 8.799618e-01 9.412244e-01 2 171324101 171324242 142 - 1.858 1.866 0.028
ENSG00000123600 E018 73.8984658 0.0030513429 4.135252e-01 6.386636e-01 2 171324243 171324362 120 - 1.862 1.837 -0.082
ENSG00000123600 E019 52.9281241 0.0007698981 2.068047e-01 4.379076e-01 2 171325841 171325906 66 - 1.724 1.673 -0.174
ENSG00000123600 E020 0.1614157 0.0336142094 1.000000e+00   2 171325907 171326041 135 - 0.088 0.000 -10.523
ENSG00000123600 E021 75.2936761 0.0007375104 5.461224e-02 1.904693e-01 2 171326042 171326148 107 - 1.878 1.807 -0.240
ENSG00000123600 E022 1.3323997 0.1585994235 8.079712e-01   2 171326149 171326381 233 - 0.332 0.377 0.267
ENSG00000123600 E023 0.1723744 0.0513153813 2.436800e-01   2 171327004 171327065 62 - 0.000 0.165 10.877
ENSG00000123600 E024 62.6374338 0.0006181603 1.319059e-02 7.121391e-02 2 171330559 171330616 58 - 1.811 1.706 -0.356
ENSG00000123600 E025 34.3115112 0.0011227388 2.435670e-02 1.101904e-01 2 171330617 171330624 8 - 1.562 1.428 -0.458
ENSG00000123600 E026 54.4184357 0.0007430875 1.418697e-01 3.502666e-01 2 171330625 171330698 74 - 1.738 1.677 -0.207
ENSG00000123600 E027 1.8085193 0.0139516070 2.577405e-01 4.965036e-01 2 171331765 171331803 39 - 0.372 0.575 1.028
ENSG00000123600 E028 32.5617902 0.0014668114 1.521620e-01 3.655224e-01 2 171331804 171331807 4 - 1.531 1.450 -0.278
ENSG00000123600 E029 42.6848482 0.0012588432 2.529260e-01 4.911625e-01 2 171331808 171331867 60 - 1.635 1.583 -0.178
ENSG00000123600 E030 8.2663832 0.2890129481 6.605046e-01 8.102814e-01 2 171331868 171332795 928 - 0.959 0.919 -0.151
ENSG00000123600 E031 21.2672830 0.0072967637 5.708612e-01 7.509158e-01 2 171337453 171337471 19 - 1.337 1.299 -0.131
ENSG00000123600 E032 36.5690822 0.0089461267 5.309812e-01 7.227587e-01 2 171337472 171337502 31 - 1.533 1.592 0.204
ENSG00000123600 E033 67.0210302 0.0051575313 7.913037e-01 8.912079e-01 2 171339184 171339330 147 - 1.803 1.827 0.080
ENSG00000123600 E034 72.8039447 0.0044386207 3.069477e-01 5.475527e-01 2 171339331 171339474 144 - 1.858 1.811 -0.157
ENSG00000123600 E035 54.3822048 0.0011246020 5.099720e-03 3.515669e-02 2 171339475 171339540 66 - 1.758 1.623 -0.457
ENSG00000123600 E036 41.6534354 0.0027270750 8.623866e-03 5.215616e-02 2 171339541 171339554 14 - 1.650 1.497 -0.522
ENSG00000123600 E037 56.0581906 0.0007411344 1.158622e-02 6.475776e-02 2 171360422 171360513 92 - 1.766 1.651 -0.391
ENSG00000123600 E038 35.4861062 0.0012131510 2.103082e-01 4.421687e-01 2 171392043 171392197 155 - 1.557 1.491 -0.226
ENSG00000123600 E039 7.4102281 0.0562125253 8.142784e-01 9.048053e-01 2 171414603 171414726 124 - 0.921 0.875 -0.176
ENSG00000123600 E040 0.9604841 0.0521940658 9.932840e-01   2 171433026 171433219 194 - 0.279 0.284 0.031
ENSG00000123600 E041 13.9672486 0.0683215625 8.179504e-01 9.069213e-01 2 171433883 171434109 227 - 1.143 1.168 0.088
ENSG00000123600 E042 7.3344857 0.2451980447 1.619921e-01 3.797163e-01 2 171434674 171434802 129 - 0.767 1.090 1.222