ENSG00000123219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396679 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding protein_coding 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 3.7557188 0.7160398 5.404004 0.3714075 0.1566825 2.8985754 0.21244583 0.09603333 0.16046667 0.06443333 0.77271689 0.01907153 FALSE TRUE
ENST00000502997 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding protein_coding 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 1.1037472 0.6366164 1.501885 0.6366164 0.2197193 1.2253663 0.06572500 0.07023333 0.04483333 -0.02540000 0.71861821 0.01907153 FALSE FALSE
ENST00000504508 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding retained_intron 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 0.6932773 0.8867068 1.332393 0.2958402 0.2920390 0.5820993 0.04792083 0.12596667 0.03996667 -0.08600000 0.03709144 0.01907153   FALSE
ENST00000508421 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding protein_coding 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 1.1394345 1.1047088 1.365920 0.2097410 0.1874265 0.3037297 0.06947500 0.18190000 0.04043333 -0.14146667 0.01907153 0.01907153 FALSE TRUE
ENST00000510354 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding protein_coding 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 1.0458412 0.6298985 1.112393 0.1500908 0.1911348 0.8106622 0.09195417 0.09303333 0.03330000 -0.05973333 0.02507351 0.01907153 FALSE TRUE
ENST00000510693 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding protein_coding 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 4.4248792 1.1321812 8.211027 0.1467010 1.1898449 2.8475270 0.17666250 0.18486667 0.24210000 0.05723333 0.78213127 0.01907153 FALSE TRUE
ENST00000514814 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding protein_coding 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 1.7985405 0.3373662 3.455549 0.1991811 0.4319978 3.3185544 0.08794583 0.04330000 0.10316667 0.05986667 0.55178569 0.01907153 FALSE TRUE
ENST00000515497 ENSG00000123219 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPK protein_coding protein_coding 20.0903 6.662261 33.7235 1.238207 0.7742233 2.337934 3.8151319 0.1956885 8.512963 0.1956885 0.6676654 5.3728222 0.12016250 0.03966667 0.25176667 0.21210000 0.14477864 0.01907153 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000123219 E001 1.5074195 0.1963611180 1.506235e-01 3.631777e-01 5 65516534 65516601 68 - 0.257 0.560 1.706
ENSG00000123219 E002 0.0000000       5 65517766 65517766 1 -      
ENSG00000123219 E003 0.3032425 0.0261468649 1.974469e-02   5 65517767 65517819 53 - 0.000 0.363 11.691
ENSG00000123219 E004 56.3691158 0.0062271449 8.480583e-03 5.152397e-02 5 65517820 65518334 515 - 1.616 1.798 0.617
ENSG00000123219 E005 110.9205893 0.0004212685 1.410794e-01 3.491529e-01 5 65518335 65518556 222 - 1.938 2.006 0.228
ENSG00000123219 E006 62.1936238 0.0011460075 8.010140e-02 2.450207e-01 5 65518557 65518633 77 - 1.685 1.787 0.345
ENSG00000123219 E007 57.5755480 0.0009121937 9.552607e-01 9.795595e-01 5 65521475 65521528 54 - 1.671 1.683 0.040
ENSG00000123219 E008 1.4324128 0.3714382310 3.129203e-01 5.532530e-01 5 65524601 65524677 77 - 0.259 0.487 1.341
ENSG00000123219 E009 37.6382900 0.0011249823 4.331052e-01 6.535350e-01 5 65528452 65528463 12 - 1.503 1.455 -0.163
ENSG00000123219 E010 59.7544189 0.0007755187 3.894007e-01 6.199868e-01 5 65528464 65528525 62 - 1.677 1.733 0.189
ENSG00000123219 E011 38.4504368 0.0009501500 7.072298e-01 8.400577e-01 5 65528526 65528527 2 - 1.494 1.528 0.119
ENSG00000123219 E012 42.1607497 0.0010206268 8.057868e-01 8.995722e-01 5 65528528 65528542 15 - 1.536 1.561 0.085
ENSG00000123219 E013 49.2691736 0.0008299269 6.563114e-01 8.075377e-01 5 65528543 65528578 36 - 1.610 1.591 -0.064
ENSG00000123219 E014 64.0991230 0.0006064004 3.203613e-01 5.600190e-01 5 65528919 65528979 61 - 1.728 1.683 -0.152
ENSG00000123219 E015 56.6370505 0.0006554185 3.389889e-02 1.385825e-01 5 65528980 65528992 13 - 1.687 1.569 -0.403
ENSG00000123219 E016 67.8288180 0.0005687097 5.807583e-02 1.984631e-01 5 65528993 65529017 25 - 1.759 1.665 -0.318
ENSG00000123219 E017 1.5746876 0.1101600781 5.756364e-01 7.541120e-01 5 65529018 65529049 32 - 0.360 0.220 -0.968
ENSG00000123219 E018 94.1120064 0.0006379195 1.380022e-03 1.275911e-02 5 65529117 65529199 83 - 1.907 1.763 -0.484
ENSG00000123219 E019 0.8150164 0.0178915620 5.316296e-02   5 65529200 65529786 587 - 0.120 0.472 2.628
ENSG00000123219 E020 0.0000000       5 65541355 65541436 82 -      
ENSG00000123219 E021 84.5391706 0.0005865448 6.403180e-06 1.427606e-04 5 65542802 65542848 47 - 1.873 1.646 -0.769
ENSG00000123219 E022 14.3960607 0.0032974936 5.369839e-07 1.648705e-05 5 65550467 65551105 639 - 0.944 1.425 1.715
ENSG00000123219 E023 10.4181401 0.0032208632 7.248949e-06 1.586390e-04 5 65551106 65551242 137 - 0.817 1.301 1.773
ENSG00000123219 E024 95.2726140 0.0004602923 2.678286e-01 5.074467e-01 5 65551564 65551636 73 - 1.892 1.852 -0.135
ENSG00000123219 E025 89.0482519 0.0005562604 2.197171e-01 4.531080e-01 5 65552493 65552549 57 - 1.867 1.819 -0.161
ENSG00000123219 E026 98.9541894 0.0004339232 2.744813e-01 5.144527e-01 5 65554797 65554898 102 - 1.910 1.872 -0.128
ENSG00000123219 E027 64.0350154 0.0007605868 8.879399e-02 2.615521e-01 5 65554899 65554946 48 - 1.732 1.646 -0.290
ENSG00000123219 E028 14.2849393 0.0879569940 4.022906e-03 2.929220e-02 5 65554947 65555271 325 - 0.905 1.473 2.031
ENSG00000123219 E029 8.2907360 0.0041366068 5.864761e-07 1.785535e-05 5 65560970 65561115 146 - 0.696 1.271 2.154
ENSG00000123219 E030 12.4271396 0.0370105825 9.468894e-04 9.477991e-03 5 65561116 65561462 347 - 0.906 1.352 1.609
ENSG00000123219 E031 57.7795256 0.0006494329 4.486821e-01 6.647927e-01 5 65561463 65561496 34 - 1.680 1.646 -0.115
ENSG00000123219 E032 80.1543588 0.0005001717 3.691882e-01 6.034036e-01 5 65561497 65561564 68 - 1.817 1.783 -0.116
ENSG00000123219 E033 2.4516093 0.0434935668 6.609627e-01 8.105411e-01 5 65562803 65563008 206 - 0.464 0.555 0.441
ENSG00000123219 E034 44.0340994 0.0009277920 5.130594e-01 7.102905e-01 5 65563098 65563168 71 - 1.548 1.598 0.172