ENSG00000123200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000679008 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding protein_coding 22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 4.084903 2.7333156 6.697256 0.5413569 0.5284077 1.2898021 0.19680000 0.16600000 0.17476667 0.008766667 9.628832e-01 4.69831e-13 FALSE  
MSTRG.8709.10 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 3.021919 1.8599887 6.143721 0.9313389 0.8616134 1.7184296 0.11229583 0.13820000 0.16180000 0.023600000 9.065358e-01 4.69831e-13 FALSE  
MSTRG.8709.11 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 1.960914 1.3214229 4.067895 0.7477465 0.7962005 1.6148557 0.06878333 0.08793333 0.10560000 0.017666667 9.097999e-01 4.69831e-13 FALSE  
MSTRG.8709.15 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 0.220776 0.9880016 0.000000 0.5103479 0.0000000 -6.6409702 0.01643750 0.06970000 0.00000000 -0.069700000 1.874951e-01 4.69831e-13 FALSE  
MSTRG.8709.20 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 0.836825 0.0000000 2.215650 0.0000000 0.3111677 7.7980831 0.02725417 0.00000000 0.05776667 0.057766667 3.811827e-11 4.69831e-13 FALSE  
MSTRG.8709.21 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 1.216512 0.0000000 2.697219 0.0000000 0.4298975 8.0806680 0.03488333 0.00000000 0.07110000 0.071100000 1.541005e-10 4.69831e-13 FALSE  
MSTRG.8709.23 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 1.547913 0.0000000 3.498785 0.0000000 0.5535780 8.4548278 0.04950417 0.00000000 0.09143333 0.091433333 4.698310e-13 4.69831e-13 FALSE  
MSTRG.8709.6 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 2.415822 3.3382708 1.703899 2.2721746 0.9687311 -0.9661343 0.15207500 0.17330000 0.04326667 -0.130033333 9.080051e-01 4.69831e-13 FALSE  
MSTRG.8709.9 ENSG00000123200 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H13 protein_coding   22.8065 16.29547 38.30379 2.862839 1.020312 1.232507 2.938250 2.9425255 5.380034 1.1177961 0.7817389 0.8683449 0.14637500 0.19346667 0.14133333 -0.052133333 9.431766e-01 4.69831e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000123200 E001 16.6772994 0.0020905189 9.897646e-02 2.800200e-01 13 45954465 45954593 129 - 1.170 1.309 0.487
ENSG00000123200 E002 24.8032142 0.0015913365 4.704043e-01 6.803395e-01 13 45954594 45954645 52 - 1.372 1.421 0.171
ENSG00000123200 E003 38.6386052 0.0027407476 9.303172e-01 9.671239e-01 13 45954646 45954710 65 - 1.581 1.574 -0.022
ENSG00000123200 E004 223.5449029 0.0153300865 9.782413e-01 9.908815e-01 13 45954711 45956075 1365 - 2.327 2.347 0.068
ENSG00000123200 E005 243.6880499 0.0213012931 1.520470e-01 3.653341e-01 13 45956076 45956737 662 - 2.319 2.451 0.441
ENSG00000123200 E006 205.4004666 0.0017912346 4.650209e-06 1.080761e-04 13 45956738 45956871 134 - 2.239 2.384 0.487
ENSG00000123200 E007 120.3673931 0.0003660590 2.313213e-09 1.258689e-07 13 45956872 45956920 49 - 1.985 2.180 0.653
ENSG00000123200 E008 102.6252003 0.0004309547 4.619544e-09 2.339600e-07 13 45956921 45956958 38 - 1.909 2.117 0.695
ENSG00000123200 E009 71.4674094 0.0005962816 1.949149e-04 2.619997e-03 13 45956959 45956962 4 - 1.777 1.935 0.532
ENSG00000123200 E010 104.6322869 0.0004878197 1.041557e-07 3.846896e-06 13 45956963 45956978 16 - 1.927 2.115 0.630
ENSG00000123200 E011 101.6378969 0.0004393667 4.775094e-07 1.486564e-05 13 45956979 45956996 18 - 1.918 2.098 0.601
ENSG00000123200 E012 368.5780491 0.0036545586 5.513838e-03 3.729098e-02 13 45956997 45957297 301 - 2.513 2.606 0.312
ENSG00000123200 E013 292.9292795 0.0005084505 6.116454e-04 6.682414e-03 13 45959483 45959646 164 - 2.420 2.497 0.256
ENSG00000123200 E014 5.5044019 0.0202179525 1.722524e-01 3.935313e-01 13 45962176 45963841 1666 - 0.863 0.649 -0.865
ENSG00000123200 E015 293.6902094 0.0012970669 8.741435e-06 1.868090e-04 13 45963842 45964042 201 - 2.404 2.521 0.390
ENSG00000123200 E016 287.3170303 0.0002091205 2.018770e-05 3.849901e-04 13 45965280 45965429 150 - 2.409 2.499 0.301
ENSG00000123200 E017 84.1096918 0.0004939383 4.518246e-01 6.669698e-01 13 45965430 45965432 3 - 1.907 1.935 0.094
ENSG00000123200 E018 600.2505392 0.0011123570 4.448278e-02 1.663041e-01 13 45967504 45968028 525 - 2.748 2.788 0.133
ENSG00000123200 E019 868.0092578 0.0001386579 8.796291e-01 9.410921e-01 13 45968748 45969971 1224 - 2.924 2.923 -0.002
ENSG00000123200 E020 155.0432309 0.0027755733 9.896297e-01 9.965434e-01 13 45970362 45970465 104 - 2.178 2.171 -0.025
ENSG00000123200 E021 467.6975637 0.0043460070 5.051007e-01 7.043720e-01 13 45975283 45975838 556 - 2.666 2.634 -0.106
ENSG00000123200 E022 20.8741439 0.0229593946 4.251967e-01 6.474153e-01 13 45976182 45976265 84 - 1.296 1.372 0.263
ENSG00000123200 E023 245.9901418 0.0002492184 3.274970e-06 8.003528e-05 13 45979813 45980004 192 - 2.415 2.298 -0.391
ENSG00000123200 E024 443.6522180 0.0026464416 6.931491e-07 2.066948e-05 13 45985297 45985761 465 - 2.683 2.529 -0.512
ENSG00000123200 E025 309.2148080 0.0056099789 6.642868e-05 1.061552e-03 13 45988787 45989097 311 - 2.533 2.357 -0.585
ENSG00000123200 E026 11.0058606 0.0033175722 8.972305e-02 2.632795e-01 13 46001163 46001460 298 - 1.126 0.941 -0.676
ENSG00000123200 E027 165.8509411 0.0003801968 6.243474e-06 1.395480e-04 13 46003139 46003336 198 - 2.255 2.116 -0.464
ENSG00000123200 E028 1.5412232 0.0135711930 5.361838e-03 3.650577e-02 13 46010150 46010347 198 - 0.172 0.646 2.822
ENSG00000123200 E029 147.1771418 0.0003844992 1.966399e-04 2.637339e-03 13 46010348 46010505 158 - 2.197 2.076 -0.404
ENSG00000123200 E030 153.6456967 0.0030081207 6.155326e-07 1.861318e-05 13 46011415 46011554 140 - 2.241 2.031 -0.705
ENSG00000123200 E031 0.1614157 0.0351510831 8.707043e-01   13 46011555 46011555 1 - 0.094 0.001 -7.537
ENSG00000123200 E032 145.4649776 0.0011213388 1.182344e-10 8.266333e-09 13 46020449 46020557 109 - 2.224 1.990 -0.784
ENSG00000123200 E033 0.4576437 0.2261442831 1.000000e+00   13 46042157 46042163 7 - 0.170 0.156 -0.144
ENSG00000123200 E034 131.9989279 0.0003934589 5.037457e-11 3.788645e-09 13 46042164 46042275 112 - 2.179 1.950 -0.770
ENSG00000123200 E035 113.7316921 0.0004113316 2.812900e-08 1.192151e-06 13 46044955 46045064 110 - 2.110 1.903 -0.694
ENSG00000123200 E036 107.6683894 0.0063296505 9.203351e-03 5.472673e-02 13 46045391 46045513 123 - 2.071 1.926 -0.486
ENSG00000123200 E037 26.1715512 0.0598218030 5.922893e-01 7.651444e-01 13 46045514 46045516 3 - 1.455 1.366 -0.307
ENSG00000123200 E038 18.5375495 0.1610474886 3.687718e-01 6.030245e-01 13 46051932 46051986 55 - 1.337 1.165 -0.606
ENSG00000123200 E039 9.1157898 0.2292789067 4.776692e-01 6.855512e-01 13 46051987 46051989 3 - 1.057 0.872 -0.690
ENSG00000123200 E040 50.3114955 0.1534643155 8.219703e-01 9.090892e-01 13 46052404 46052697 294 - 1.699 1.691 -0.029
ENSG00000123200 E041 33.1774174 0.8055596830 6.387963e-01 7.961818e-01 13 46052698 46052776 79 - 1.519 1.518 -0.006