ENSG00000123191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242839 ENSG00000123191 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP7B protein_coding protein_coding 9.036909 10.33589 8.251149 0.9019112 0.3380137 -0.3246428 5.1503266 6.6455445 4.9561236 0.51325291 0.2333983 -0.4224365 0.56970833 0.64650000 0.60500000 -0.04150000 0.9171744036 0.0001444675 FALSE TRUE
ENST00000634844 ENSG00000123191 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP7B protein_coding protein_coding 9.036909 10.33589 8.251149 0.9019112 0.3380137 -0.3246428 0.4209807 0.1760307 0.7580260 0.09118409 0.2270257 2.0456141 0.04576667 0.01596667 0.08990000 0.07393333 0.0850874115 0.0001444675 FALSE TRUE
ENST00000674147 ENSG00000123191 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP7B protein_coding protein_coding 9.036909 10.33589 8.251149 0.9019112 0.3380137 -0.3246428 0.4381964 0.6686933 0.0000000 0.24150320 0.0000000 -6.0846878 0.04882917 0.06483333 0.00000000 -0.06483333 0.0005561477 0.0001444675 FALSE TRUE
MSTRG.8817.10 ENSG00000123191 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP7B protein_coding   9.036909 10.33589 8.251149 0.9019112 0.3380137 -0.3246428 0.5905388 0.9083288 0.5685163 0.27492705 0.3282671 -0.6666532 0.06580000 0.08950000 0.06586667 -0.02363333 0.8821626571 0.0001444675 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000123191 E001 0.0000000       13 51923261 51923393 133 -      
ENSG00000123191 E002 0.6542209 0.0193874923 0.5650525509   13 51924295 51924387 93 - 0.257 0.181 -0.647
ENSG00000123191 E003 0.1779838 0.0639234128 0.2738674882   13 51930436 51930564 129 - 0.148 0.000 -9.506
ENSG00000123191 E004 1.8118297 0.0202490124 0.5387089159 0.728111923 13 51932352 51932468 117 - 0.480 0.407 -0.380
ENSG00000123191 E005 1.0018026 0.0436637822 0.5101783004   13 51932669 51932673 5 - 0.344 0.249 -0.641
ENSG00000123191 E006 0.8405746 0.0168698736 0.2796827404   13 51932674 51932679 6 - 0.345 0.181 -1.229
ENSG00000123191 E007 1.4487773 0.3267157898 0.9257748829 0.965051874 13 51932680 51932683 4 - 0.343 0.377 0.201
ENSG00000123191 E008 3.3435338 0.3727878130 0.3719576556 0.605569600 13 51932684 51932703 20 - 0.343 0.726 1.843
ENSG00000123191 E009 2.9793839 0.3299828115 0.2233421321 0.457377242 13 51932704 51932704 1 - 0.256 0.698 2.317
ENSG00000123191 E010 5.3191077 0.1668474358 0.1226227222 0.319932060 13 51932705 51932751 47 - 0.476 0.898 1.791
ENSG00000123191 E011 67.6467078 0.4340283724 0.1255022103 0.324638425 13 51932752 51933068 317 - 1.549 1.936 1.310
ENSG00000123191 E012 51.0035769 0.3969537372 0.1839583007 0.409113952 13 51933069 51933137 69 - 1.495 1.797 1.028
ENSG00000123191 E013 91.6050394 0.5763667464 0.1953491235 0.423769230 13 51933138 51933317 180 - 1.713 2.057 1.158
ENSG00000123191 E014 277.9236275 1.2707214761 0.3764372726 0.609392463 13 51933318 51934244 927 - 2.230 2.525 0.983
ENSG00000123191 E015 51.3340698 0.4895427613 0.3636051029 0.598697295 13 51934245 51934289 45 - 1.598 1.764 0.563
ENSG00000123191 E016 124.5820806 0.9915179362 0.4051202307 0.632370357 13 51934290 51934603 314 - 1.930 2.162 0.779
ENSG00000123191 E017 46.8558437 0.3501404679 0.1631738838 0.381442846 13 51934604 51934685 82 - 1.445 1.766 1.096
ENSG00000123191 E018 25.0502295 0.1692614691 0.1744772221 0.396486716 13 51934686 51934690 5 - 1.222 1.490 0.933
ENSG00000123191 E019 25.1111369 0.1757090253 0.1913848617 0.418625796 13 51934691 51934692 2 - 1.232 1.488 0.888
ENSG00000123191 E020 48.9046190 0.4134120721 0.2578390358 0.496604987 13 51934693 51934755 63 - 1.521 1.765 0.829
ENSG00000123191 E021 94.4230846 0.6384134264 0.2819574569 0.522287634 13 51934756 51935029 274 - 1.790 2.050 0.874
ENSG00000123191 E022 46.9574967 0.0147309970 0.0533226040 0.187498024 13 51935593 51935695 103 - 1.531 1.736 0.699
ENSG00000123191 E023 58.0140026 0.0014258831 0.1003306393 0.282412185 13 51937276 51937393 118 - 1.664 1.806 0.480
ENSG00000123191 E024 0.0000000       13 51937394 51937475 82 -      
ENSG00000123191 E025 100.3899072 0.0005318458 0.0767295379 0.238220814 13 51937476 51937679 204 - 1.908 2.035 0.427
ENSG00000123191 E026 89.4697469 0.0005284893 0.5668314905 0.747886130 13 51939051 51939193 143 - 1.919 1.957 0.128
ENSG00000123191 E027 1.7246240 0.1772420424 0.6797186884 0.822504074 13 51939194 51939990 797 - 0.419 0.413 -0.033
ENSG00000123191 E028 1.0697382 0.0155288927 0.6987326105   13 51940046 51941080 1035 - 0.345 0.307 -0.234
ENSG00000123191 E029 94.1901040 0.0058146623 0.3843145678 0.615877135 13 51941081 51941224 144 - 1.950 1.978 0.095
ENSG00000123191 E030 84.9102478 0.0034107306 0.1748742617 0.396995853 13 51942386 51942554 169 - 1.920 1.922 0.006
ENSG00000123191 E031 53.3992133 0.0008760740 0.1517576838 0.364871167 13 51944109 51944191 83 - 1.728 1.717 -0.039
ENSG00000123191 E032 60.5899350 0.0009745896 0.7862668714 0.888282790 13 51944192 51944291 100 - 1.744 1.792 0.160
ENSG00000123191 E033 19.8316683 0.0852999829 0.7691507022 0.878149570 13 51944292 51946283 1992 - 1.196 1.362 0.582
ENSG00000123191 E034 77.3419929 0.0117609395 0.7318473545 0.855311875 13 51946284 51946478 195 - 1.851 1.900 0.164
ENSG00000123191 E035 10.5989516 0.1549662586 0.9722451593 0.988092191 13 51946479 51947850 1372 - 0.961 1.105 0.529
ENSG00000123191 E036 1.0885192 0.0147818239 0.6969491036   13 51947851 51947870 20 - 0.345 0.307 -0.234
ENSG00000123191 E037 8.0007122 0.0406196925 0.5629358053 0.745390645 13 51947871 51949661 1791 - 0.958 0.949 -0.032
ENSG00000123191 E038 40.9371673 0.0137459651 0.7243626378 0.850756511 13 51949662 51949715 54 - 1.587 1.629 0.143
ENSG00000123191 E039 49.7370055 0.0063613067 0.3946529105 0.624044593 13 51949716 51949796 81 - 1.687 1.699 0.041
ENSG00000123191 E040 72.9211761 0.0290498276 0.3839992427 0.615576026 13 51950007 51950161 155 - 1.857 1.855 -0.007
ENSG00000123191 E041 66.6249528 0.0263837188 0.1785781852 0.402087999 13 51950272 51950399 128 - 1.842 1.801 -0.138
ENSG00000123191 E042 53.0981467 0.0015932428 0.0460621579 0.170189366 13 51957516 51957607 92 - 1.744 1.704 -0.138
ENSG00000123191 E043 4.3014536 0.0063541311 0.1406945725 0.348588486 13 51957608 51958310 703 - 0.534 0.807 1.158
ENSG00000123191 E044 34.3585103 0.0041271465 0.7632386259 0.874587852 13 51958311 51958363 53 - 1.507 1.552 0.154
ENSG00000123191 E045 32.1574567 0.0039927110 0.7648151533 0.875536437 13 51958364 51958400 37 - 1.478 1.523 0.152
ENSG00000123191 E046 47.8298347 0.0054449622 0.2190069035 0.452264329 13 51958401 51958544 144 - 1.680 1.673 -0.023
ENSG00000123191 E047 19.3894846 0.0961232514 0.5863863597 0.761207228 13 51958545 51960147 1603 - 1.277 1.308 0.110
ENSG00000123191 E048 63.2491417 0.0007411206 0.0232794549 0.106825788 13 51960148 51960322 175 - 1.819 1.775 -0.149
ENSG00000123191 E049 39.3143391 0.0104499010 0.0933801631 0.270027682 13 51961837 51961913 77 - 1.621 1.565 -0.191
ENSG00000123191 E050 0.5061644 0.0997830069 1.0000000000   13 51964780 51964871 92 - 0.147 0.181 0.359
ENSG00000123191 E051 44.6831232 0.0015519899 0.0026026026 0.020978820 13 51964872 51964923 52 - 1.705 1.599 -0.358
ENSG00000123191 E052 59.6854966 0.0041426184 0.0001993697 0.002668471 13 51964924 51965033 110 - 1.848 1.713 -0.454
ENSG00000123191 E053 65.8088089 0.0132019482 0.0002189252 0.002880971 13 51968444 51968607 164 - 1.917 1.735 -0.613
ENSG00000123191 E054 1.1735568 0.0183344424 0.6946841532   13 51968880 51969169 290 - 0.257 0.360 0.676
ENSG00000123191 E055 0.4646582 0.0217681645 1.0000000000   13 51969170 51969463 294 - 0.147 0.180 0.351
ENSG00000123191 E056 2.4905721 0.1444449601 0.2526996735 0.490829635 13 51969464 51970491 1028 - 0.631 0.449 -0.852
ENSG00000123191 E057 80.7255228 0.0261955673 0.0139056878 0.073968102 13 51970492 51970745 254 - 1.977 1.848 -0.436
ENSG00000123191 E058 24.4078343 0.0112900469 0.0829159002 0.250556648 13 51970746 51970749 4 - 1.436 1.358 -0.269
ENSG00000123191 E059 0.0000000       13 51971074 51971118 45 -      
ENSG00000123191 E060 0.9706349 0.0153552603 0.3099549333   13 51972595 51972832 238 - 0.147 0.360 1.674
ENSG00000123191 E061 60.9405852 0.0306760736 0.0750228901 0.234871643 13 51973935 51974084 150 - 1.832 1.743 -0.302
ENSG00000123191 E062 84.7704462 0.0140796152 0.0017034839 0.015041374 13 51974085 51974417 333 - 2.000 1.862 -0.464
ENSG00000123191 E063 146.8414608 0.0221948934 0.0004784122 0.005480296 13 51974418 51975013 596 - 2.259 2.081 -0.595
ENSG00000123191 E064 53.0309032 0.0007987031 0.0001239216 0.001785873 13 51975014 51975168 155 - 1.795 1.667 -0.434
ENSG00000123191 E065 0.0000000       13 51977406 51977614 209 -      
ENSG00000123191 E066 0.0000000       13 51978820 51978991 172 -      
ENSG00000123191 E067 38.1301537 0.4370666153 0.5574148447 0.741405095 13 52011287 52011391 105 - 1.543 1.604 0.209
ENSG00000123191 E068 36.6210640 0.4731466122 0.6837008748 0.825071122 13 52011392 52011590 199 - 1.567 1.563 -0.015
ENSG00000123191 E069 16.0993016 0.1568090533 0.7785914750 0.883900930 13 52012020 52012193 174 - 1.200 1.239 0.136