ENSG00000123094

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405154 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding protein_coding 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.96818735 0.00000000 2.50327580 0.00000000 0.86337748 7.9734252 0.16704583 0.00000000 0.40253333 0.40253333 0.0007438478 0.0007438478 FALSE TRUE
ENST00000538081 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding processed_transcript 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.07100637 0.08564322 0.07721096 0.05044411 0.07721096 -0.1331533 0.05490417 0.12453333 0.01300000 -0.11153333 0.4770566680 0.0007438478   FALSE
ENST00000538365 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding processed_transcript 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.04299054 0.07011760 0.06304430 0.07011760 0.06304430 -0.1333474 0.02467917 0.06413333 0.01230000 -0.05183333 0.8318924369 0.0007438478   FALSE
ENST00000539545 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding nonsense_mediated_decay 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.13355298 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.11575417 0.00000000 0.00000000 0.00000000   0.0007438478 TRUE TRUE
ENST00000541490 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding protein_coding 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.68841029 0.29435432 1.04209566 0.29435432 0.67009000 1.7894421 0.23947917 0.26920000 0.19013333 -0.07906667 0.9061718494 0.0007438478 FALSE TRUE
ENST00000542004 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding protein_coding 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.52909137 0.00000000 0.64766091 0.00000000 0.36491229 6.0392720 0.08207500 0.00000000 0.10630000 0.10630000 0.6336778260 0.0007438478 FALSE TRUE
ENST00000688511 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding protein_coding 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.25704059 0.29040236 0.93219675 0.17789198 0.52793814 1.6491322 0.15299167 0.36026667 0.16560000 -0.19466667 0.8950049502 0.0007438478 FALSE TRUE
ENST00000689635 ENSG00000123094 HEK293_OSMI2_6hA HEK293_TMG_6hB RASSF8 protein_coding protein_coding 3.54302 0.8784674 5.948525 0.1411444 0.4789852 2.745565 0.48272387 0.04447246 0.19075334 0.04447246 0.19075334 1.8818250 0.08887083 0.04783333 0.02813333 -0.01970000 0.8769689599 0.0007438478 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000123094 E001 0.1723744 0.0896304175 0.054330124   12 25958232 25958342 111 + 0.000 0.262 11.864
ENSG00000123094 E002 0.4043710 0.0377714147 0.033899846   12 25958682 25959028 347 + 0.051 0.423 3.713
ENSG00000123094 E003 0.0000000       12 25959029 25959057 29 +      
ENSG00000123094 E004 0.0000000       12 25959058 25959064 7 +      
ENSG00000123094 E005 0.2735028 0.0274424043 0.172896093   12 25959065 25959080 16 + 0.051 0.261 2.717
ENSG00000123094 E006 1.9434036 0.2692175346 0.862518557 0.931730503 12 25959081 25959148 68 + 0.372 0.416 0.241
ENSG00000123094 E007 0.1723744 0.0896304175 0.054330124   12 25973755 25973887 133 + 0.000 0.262 13.377
ENSG00000123094 E008 0.0000000       12 25995004 25995036 33 +      
ENSG00000123094 E009 4.3498634 0.0266152437 0.470108760 0.680161190 12 25995037 25995130 94 + 0.577 0.710 0.574
ENSG00000123094 E010 0.0000000       12 26011736 26011777 42 +      
ENSG00000123094 E011 0.0000000       12 26011778 26011821 44 +      
ENSG00000123094 E012 1.0177506 0.0205354378 0.002941738   12 26020145 26020504 360 + 0.098 0.635 3.719
ENSG00000123094 E013 0.0000000       12 26021440 26021518 79 +      
ENSG00000123094 E014 0.0000000       12 26052564 26052568 5 +      
ENSG00000123094 E015 0.0000000       12 26052569 26052602 34 +      
ENSG00000123094 E016 0.1723744 0.0896304175 0.054330124   12 26052603 26052996 394 + 0.000 0.262 13.377
ENSG00000123094 E017 4.5181265 0.0065241275 0.941137837 0.972804108 12 26055236 26055278 43 + 0.617 0.634 0.075
ENSG00000123094 E018 20.5514910 0.0017937055 0.144670284 0.354434577 12 26055279 26055446 168 + 1.200 1.039 -0.579
ENSG00000123094 E019 56.8442205 0.0008227493 0.003719811 0.027581951 12 26064498 26065027 530 + 1.624 1.426 -0.681
ENSG00000123094 E020 46.0874007 0.0008237808 0.047541559 0.173884908 12 26065028 26065387 360 + 1.529 1.383 -0.502
ENSG00000123094 E021 22.1124823 0.0020032523 0.669747656 0.816119945 12 26067569 26067713 145 + 1.216 1.178 -0.135
ENSG00000123094 E022 25.7429203 0.0028489037 0.101730685 0.284893227 12 26068697 26068923 227 + 1.292 1.127 -0.583
ENSG00000123094 E023 180.7038952 0.0007225663 0.798317437 0.895318193 12 26068924 26071655 2732 + 2.095 2.109 0.048
ENSG00000123094 E024 81.8776033 0.0012330536 0.000113780 0.001663864 12 26071656 26072871 1216 + 1.725 1.914 0.639
ENSG00000123094 E025 0.2852693 0.2337201499 1.000000000   12 26079033 26079892 860 + 0.096 0.000 -11.174