ENSG00000122783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393114 ENSG00000122783 HEK293_OSMI2_6hA HEK293_TMG_6hB CYREN protein_coding protein_coding 60.56847 63.36264 46.98034 3.086176 2.861008 -0.431496 19.553280 18.150582 16.757921 1.5047345 2.7797756 -0.11510668 0.32341667 0.28553333 0.35193333 0.06640000 0.706887178 0.002991813 FALSE TRUE
ENST00000424142 ENSG00000122783 HEK293_OSMI2_6hA HEK293_TMG_6hB CYREN protein_coding protein_coding 60.56847 63.36264 46.98034 3.086176 2.861008 -0.431496 19.385967 22.287096 11.185558 1.3683352 0.7391762 -0.99392940 0.31435000 0.35133333 0.23853333 -0.11280000 0.002991813 0.002991813 FALSE FALSE
ENST00000487774 ENSG00000122783 HEK293_OSMI2_6hA HEK293_TMG_6hB CYREN protein_coding retained_intron 60.56847 63.36264 46.98034 3.086176 2.861008 -0.431496 3.749678 4.501307 4.031442 1.3286326 0.1163296 -0.15867552 0.06407917 0.07330000 0.08646667 0.01316667 0.868568559 0.002991813   FALSE
ENST00000617987 ENSG00000122783 HEK293_OSMI2_6hA HEK293_TMG_6hB CYREN protein_coding protein_coding 60.56847 63.36264 46.98034 3.086176 2.861008 -0.431496 3.984535 4.752818 2.233064 0.1919896 0.8830164 -1.08634493 0.06557500 0.07566667 0.05003333 -0.02563333 0.737651259 0.002991813 FALSE FALSE
MSTRG.30736.8 ENSG00000122783 HEK293_OSMI2_6hA HEK293_TMG_6hB CYREN protein_coding   60.56847 63.36264 46.98034 3.086176 2.861008 -0.431496 5.033847 4.821440 4.884592 1.7986759 0.5499326 0.01873553 0.08535000 0.07373333 0.10623333 0.03250000 0.744847850 0.002991813 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122783 E001 3.5032339 0.3424815193 4.517399e-02 0.1680519176 7 135092363 135093378 1016 - 0.919 0.366 -2.463
ENSG00000122783 E002 11.7990904 0.0594241847 3.980604e-05 0.0006846937 7 135093379 135094582 1204 - 1.372 0.807 -2.058
ENSG00000122783 E003 0.9103477 0.0172671820 4.141004e-01   7 135147977 135148163 187 - 0.167 0.324 1.240
ENSG00000122783 E004 31.8038931 0.2374258182 9.970452e-01 1.0000000000 7 135165782 135165784 3 - 1.581 1.433 -0.507
ENSG00000122783 E005 70.4684387 0.3931955802 4.592195e-01 0.6726236141 7 135165785 135165828 44 - 1.810 1.829 0.065
ENSG00000122783 E006 685.4958658 0.0279541208 3.748370e-01 0.6080596342 7 135165829 135166343 515 - 2.782 2.816 0.112
ENSG00000122783 E007 374.4320890 0.0338081010 2.436849e-01 0.4807021302 7 135166344 135166467 124 - 2.574 2.528 -0.151
ENSG00000122783 E008 314.2336762 0.0578354422 4.369789e-01 0.6564512170 7 135166468 135166574 107 - 2.485 2.459 -0.086
ENSG00000122783 E009 186.5488437 0.0564574483 6.891121e-01 0.8285102836 7 135166575 135166599 25 - 2.233 2.246 0.043
ENSG00000122783 E010 495.9540037 0.0435896407 4.631245e-01 0.6752515220 7 135166600 135166871 272 - 2.672 2.661 -0.034
ENSG00000122783 E011 6.1242525 0.2381456708 3.265829e-01 0.5657668680 7 135167363 135167408 46 - 0.906 0.780 -0.488
ENSG00000122783 E012 276.4923600 0.0002307604 1.025026e-01 0.2862336290 7 135167732 135167807 76 - 2.384 2.424 0.131
ENSG00000122783 E013 39.1401670 0.0983055305 1.140508e-01 0.3058399572 7 135167808 135168179 372 - 1.688 1.508 -0.613
ENSG00000122783 E014 31.6392942 0.2436218090 5.240954e-01 0.7178964172 7 135168304 135168595 292 - 1.432 1.507 0.257
ENSG00000122783 E015 24.0393250 0.2183178850 5.709643e-01 0.7509807387 7 135168596 135168744 149 - 1.302 1.398 0.335
ENSG00000122783 E016 11.1440746 0.1352778820 6.002226e-01 0.7703357668 7 135168745 135168748 4 - 0.991 1.085 0.344
ENSG00000122783 E017 153.6535883 0.8301167283 3.928258e-01 0.6226686366 7 135168749 135168785 37 - 2.076 2.191 0.388
ENSG00000122783 E018 338.6636592 1.1997446033 5.043806e-01 0.7038417302 7 135168786 135168930 145 - 2.456 2.518 0.209
ENSG00000122783 E019 208.1503938 1.0304683857 5.348222e-01 0.7255270465 7 135168931 135168968 38 - 2.275 2.295 0.069
ENSG00000122783 E020 291.7953837 1.1555808350 5.260448e-01 0.7192681523 7 135168969 135169060 92 - 2.407 2.447 0.135
ENSG00000122783 E021 7.5017863 0.0410988642 6.987414e-01 0.8348038919 7 135169422 135169474 53 - 0.950 0.885 -0.246
ENSG00000122783 E022 20.9397038 0.1214168983 4.231387e-01 0.6459497119 7 135170276 135170398 123 - 1.173 1.364 0.673
ENSG00000122783 E023 147.1482512 0.0274460685 2.640736e-01 0.5033377437 7 135170399 135170651 253 - 2.036 2.180 0.482
ENSG00000122783 E024 155.2416603 0.0002730965 6.644699e-02 0.2170669800 7 135170652 135170795 144 - 2.200 2.146 -0.180