ENSG00000122779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343526 ENSG00000122779 HEK293_OSMI2_6hA HEK293_TMG_6hB TRIM24 protein_coding protein_coding 16.25983 11.80953 25.32084 2.694756 1.513659 1.099721 7.139882 6.245300 9.58429 1.6744435 0.3267209 0.6170971 0.4713750 0.5148000 0.3800333 -0.1347667 0.142688243 0.009047045 FALSE TRUE
MSTRG.30778.5 ENSG00000122779 HEK293_OSMI2_6hA HEK293_TMG_6hB TRIM24 protein_coding   16.25983 11.80953 25.32084 2.694756 1.513659 1.099721 8.295811 4.913576 15.02892 0.9587968 1.2648464 1.6109225 0.4285375 0.4252333 0.5919000 0.1666667 0.009047045 0.009047045 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122779 E001 37.3538872 0.0015487103 2.807369e-01 5.209929e-01 7 138460259 138460434 176 + 1.557 1.621 0.220
ENSG00000122779 E002 41.4008528 0.0014512769 1.038904e-02 5.981688e-02 7 138460435 138460606 172 + 1.563 1.708 0.492
ENSG00000122779 E003 68.7396707 0.0153987505 4.096244e-01 6.357694e-01 7 138460607 138460912 306 + 1.806 1.883 0.261
ENSG00000122779 E004 1.4162046 0.2382931591 2.920755e-01 5.327612e-01 7 138461065 138461302 238 + 0.256 0.481 1.334
ENSG00000122779 E005 1.9473273 0.0569956476 9.782837e-01 9.909090e-01 7 138495633 138495664 32 + 0.463 0.465 0.014
ENSG00000122779 E006 1.5947562 0.0124360227 9.325585e-01 9.684396e-01 7 138495665 138495672 8 + 0.418 0.405 -0.072
ENSG00000122779 E007 2.0344764 0.0755095692 8.444739e-01 9.218488e-01 7 138495673 138495725 53 + 0.463 0.515 0.257
ENSG00000122779 E008 117.1132849 0.0019855297 1.050497e-04 1.559020e-03 7 138504290 138504408 119 + 2.126 1.973 -0.514
ENSG00000122779 E009 0.3032425 0.0274424043 1.180765e-01   7 138514400 138514589 190 + 0.000 0.248 11.576
ENSG00000122779 E010 0.1308682 0.0326491905 3.392877e-01   7 138514590 138514844 255 + 0.000 0.141 10.493
ENSG00000122779 E011 152.6089435 0.0016350007 4.068784e-10 2.536612e-08 7 138515212 138515359 148 + 2.263 2.041 -0.742
ENSG00000122779 E012 129.6570413 0.0004233288 8.487709e-11 6.105075e-09 7 138519189 138519321 133 + 2.191 1.974 -0.726
ENSG00000122779 E013 139.5057855 0.0077093102 5.989076e-03 3.967556e-02 7 138525241 138525357 117 + 2.203 2.043 -0.537
ENSG00000122779 E014 139.3813256 0.0037858698 3.129223e-02 1.311939e-01 7 138529116 138529230 115 + 2.181 2.079 -0.342
ENSG00000122779 E015 147.2886297 0.0047209848 3.437039e-01 5.813693e-01 7 138538657 138538803 147 + 2.187 2.137 -0.167
ENSG00000122779 E016 135.6426243 0.0015647532 7.624704e-01 8.740719e-01 7 138551063 138551180 118 + 2.138 2.122 -0.052
ENSG00000122779 E017 113.4778469 0.0036754118 2.433967e-01 4.804645e-01 7 138554698 138554769 72 + 2.076 2.015 -0.206
ENSG00000122779 E018 126.8164472 0.0004085378 4.695497e-03 3.297781e-02 7 138554770 138554864 95 + 2.139 2.046 -0.310
ENSG00000122779 E019 109.4038855 0.0011633955 2.409639e-01 4.776655e-01 7 138554865 138554966 102 + 2.058 2.014 -0.147
ENSG00000122779 E020 0.3032425 0.0274424043 1.180765e-01   7 138556269 138556398 130 + 0.000 0.248 11.576
ENSG00000122779 E021 208.7276881 0.0002718745 1.523190e-01 3.657505e-01 7 138567481 138567654 174 + 2.334 2.297 -0.123
ENSG00000122779 E022 199.3824437 0.0003305652 8.650245e-01 9.331772e-01 7 138570830 138571003 174 + 2.299 2.303 0.015
ENSG00000122779 E023 142.7602609 0.0004085176 9.492867e-01 9.767406e-01 7 138573507 138573642 136 + 2.156 2.157 0.005
ENSG00000122779 E024 131.5079644 0.0003558118 3.976328e-01 6.264875e-01 7 138576373 138576445 73 + 2.106 2.132 0.087
ENSG00000122779 E025 97.9388996 0.0006988219 8.198447e-01 9.080020e-01 7 138577420 138577434 15 + 1.986 1.994 0.027
ENSG00000122779 E026 209.5583275 0.0002228589 2.248617e-01 4.592507e-01 7 138577435 138577588 154 + 2.309 2.339 0.098
ENSG00000122779 E027 317.8783963 0.0002197740 2.831923e-01 5.236322e-01 7 138579204 138579532 329 + 2.493 2.514 0.070
ENSG00000122779 E028 211.6431217 0.0002581373 6.882415e-01 8.279898e-01 7 138580562 138580694 133 + 2.322 2.332 0.032
ENSG00000122779 E029 153.7097526 0.0014441889 2.574034e-01 4.961423e-01 7 138581697 138581771 75 + 2.172 2.209 0.123
ENSG00000122779 E030 186.8443121 0.0050608629 9.606722e-03 5.641615e-02 7 138583850 138583999 150 + 2.224 2.326 0.341
ENSG00000122779 E031 683.8140375 0.0002342321 4.303380e-19 1.103947e-16 7 138584742 138589996 5255 + 2.777 2.899 0.406