ENSG00000122741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377724 ENSG00000122741 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF10 protein_coding protein_coding 13.46279 9.569305 19.70869 1.710384 0.7372 1.041571 4.0712484 2.860156 4.589668 0.5963628 0.082263704 0.6804002 0.30207083 0.2947000 0.23343333 -0.06126667 4.245343e-01 4.496869e-12 FALSE TRUE
ENST00000461549 ENSG00000122741 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF10 protein_coding processed_transcript 13.46279 9.569305 19.70869 1.710384 0.7372 1.041571 2.2461282 1.691793 3.619641 0.1667372 0.534657231 1.0927713 0.16928333 0.1853333 0.18553333 0.00020000 1.000000e+00 4.496869e-12 FALSE FALSE
MSTRG.32700.3 ENSG00000122741 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF10 protein_coding   13.46279 9.569305 19.70869 1.710384 0.7372 1.041571 1.0054193 1.010927 1.128655 0.1958830 0.004046037 0.1574505 0.08594583 0.1049000 0.05746667 -0.04743333 8.240897e-02 4.496869e-12 FALSE TRUE
MSTRG.32700.4 ENSG00000122741 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF10 protein_coding   13.46279 9.569305 19.70869 1.710384 0.7372 1.041571 0.5294453 0.000000 2.751082 0.0000000 0.418874964 8.1090897 0.03014583 0.0000000 0.14046667 0.14046667 4.496869e-12 4.496869e-12 FALSE TRUE
MSTRG.32700.6 ENSG00000122741 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF10 protein_coding   13.46279 9.569305 19.70869 1.710384 0.7372 1.041571 5.1054043 3.943498 7.351785 0.7679634 1.175444427 0.8969260 0.37511250 0.4089333 0.37046667 -0.03846667 8.859704e-01 4.496869e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122741 E001 0.8701267 0.0172671820 6.006115e-02   9 37800554 37800647 94 + 0.100 0.418 2.652
ENSG00000122741 E002 5.9338650 0.0050935383 8.457621e-02 2.538931e-01 9 37800797 37800818 22 + 0.751 0.958 0.801
ENSG00000122741 E003 21.3122835 0.0017241741 2.028960e-10 1.347005e-08 9 37800819 37800919 101 + 1.091 1.563 1.650
ENSG00000122741 E004 38.1713089 0.0182940515 8.865827e-08 3.329558e-06 9 37800920 37801036 117 + 1.348 1.798 1.536
ENSG00000122741 E005 88.1245793 0.0172597378 2.208598e-06 5.690964e-05 9 37801037 37801405 369 + 1.784 2.111 1.099
ENSG00000122741 E006 3.1629273 0.0254377179 8.091861e-05 1.253589e-03 9 37801561 37801651 91 + 0.248 0.894 3.147
ENSG00000122741 E007 3.7821743 0.0070384416 1.738762e-03 1.528998e-02 9 37801652 37801716 65 + 0.447 0.896 1.930
ENSG00000122741 E008 28.9120344 0.3030286271 2.013089e-01 4.313667e-01 9 37819288 37819293 6 + 1.367 1.587 0.758
ENSG00000122741 E009 87.3756681 0.0006744374 3.939883e-01 6.235141e-01 9 37819294 37819401 108 + 1.928 1.950 0.076
ENSG00000122741 E010 122.9463749 0.0015401948 3.421934e-01 5.799227e-01 9 37842089 37842286 198 + 2.098 2.055 -0.146
ENSG00000122741 E011 79.8215385 0.0004850337 8.262317e-01 9.116086e-01 9 37854780 37854818 39 + 1.899 1.898 -0.004
ENSG00000122741 E012 140.1442685 0.0004257675 3.697191e-01 6.037890e-01 9 37854819 37854982 164 + 2.132 2.150 0.059
ENSG00000122741 E013 67.0761568 0.0006271361 3.628768e-03 2.709022e-02 9 37857241 37857351 111 + 1.770 1.887 0.393
ENSG00000122741 E014 3.5288623 0.0069396460 1.233984e-01 3.211394e-01 9 37858480 37858520 41 + 0.731 0.480 -1.115
ENSG00000122741 E015 165.9465177 0.0003834960 4.091565e-02 1.570690e-01 9 37860048 37860193 146 + 2.192 2.239 0.155
ENSG00000122741 E016 11.7317911 0.0027929376 7.484848e-01 8.657948e-01 9 37860194 37860441 248 + 1.117 1.076 -0.148
ENSG00000122741 E017 963.3645008 0.0010983657 5.131152e-19 1.308390e-16 9 37861140 37867666 6527 + 3.015 2.903 -0.371