ENSG00000122705

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345519 ENSG00000122705 HEK293_OSMI2_6hA HEK293_TMG_6hB CLTA protein_coding protein_coding 201.5954 185.9484 174.3242 28.74214 10.86235 -0.09312366 164.39421 170.875969 112.29422 28.49503 1.539764 -0.6056218 0.8191625 0.91536667 0.6486333 -0.2667333 0.0006733128 0.0006733128 FALSE TRUE
MSTRG.32649.3 ENSG00000122705 HEK293_OSMI2_6hA HEK293_TMG_6hB CLTA protein_coding   201.5954 185.9484 174.3242 28.74214 10.86235 -0.09312366 27.88583 5.154128 55.08639 2.86816 9.680957 3.4153610 0.1340083 0.03006667 0.3112333 0.2811667 0.3134150640 0.0006733128 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122705 E001 0.3088520 2.718459e-02 7.847088e-01   9 36190796 36190806 11 + 0.140 0.105 -0.476
ENSG00000122705 E002 1.0287093 6.836608e-02 2.208599e-01   9 36190807 36190834 28 + 0.140 0.376 1.855
ENSG00000122705 E003 1.3375613 6.970974e-02 3.783269e-01   9 36190835 36190851 17 + 0.246 0.423 1.108
ENSG00000122705 E004 1.2066931 1.930817e-01 5.457217e-01   9 36190852 36190855 4 + 0.248 0.378 0.850
ENSG00000122705 E005 1.0287093 6.836608e-02 2.208599e-01   9 36190856 36190863 8 + 0.140 0.376 1.855
ENSG00000122705 E006 1.5051340 8.634442e-02 6.601888e-01 8.100846e-01 9 36190864 36190880 17 + 0.331 0.425 0.540
ENSG00000122705 E007 15.0294093 9.276221e-02 1.907481e-01 4.178232e-01 9 36190881 36190911 31 + 1.301 1.116 -0.657
ENSG00000122705 E008 29.1213117 1.229484e-02 1.181265e-01 3.127774e-01 9 36190912 36190920 9 + 1.538 1.425 -0.388
ENSG00000122705 E009 53.5056116 9.161056e-03 3.864577e-01 6.176769e-01 9 36190921 36190930 10 + 1.756 1.715 -0.139
ENSG00000122705 E010 93.6640475 2.836791e-03 1.975322e-01 4.265326e-01 9 36190931 36190931 1 + 1.994 1.954 -0.134
ENSG00000122705 E011 153.6225806 9.032073e-04 3.214709e-01 5.609866e-01 9 36190932 36190936 5 + 2.154 2.203 0.166
ENSG00000122705 E012 354.0977826 8.742558e-04 2.838315e-06 7.081109e-05 9 36190937 36190962 26 + 2.463 2.592 0.427
ENSG00000122705 E013 885.0344342 1.263125e-03 4.356925e-17 8.752117e-15 9 36190963 36191164 202 + 2.821 3.008 0.622
ENSG00000122705 E014 791.6118712 4.901637e-03 1.518352e-06 4.090277e-05 9 36191165 36191273 109 + 2.773 2.960 0.622
ENSG00000122705 E015 533.5801115 3.677182e-04 3.921252e-01 6.221331e-01 9 36197551 36197588 38 + 2.702 2.737 0.114
ENSG00000122705 E016 1325.9344848 7.206599e-05 6.011740e-17 1.188512e-14 9 36198979 36199096 118 + 3.151 3.090 -0.205
ENSG00000122705 E017 1501.2504311 8.849652e-05 7.832951e-15 1.168906e-12 9 36204068 36204179 112 + 3.200 3.148 -0.175
ENSG00000122705 E018 6.6768865 3.034337e-02 3.977053e-03 2.902678e-02 9 36209267 36209320 54 + 0.563 1.015 1.817
ENSG00000122705 E019 4.9108240 1.495054e-02 2.003546e-02 9.599601e-02 9 36210625 36210660 36 + 0.515 0.880 1.535
ENSG00000122705 E020 2.5529842 1.857217e-01 7.956963e-02 2.440094e-01 9 36210661 36210661 1 + 0.245 0.669 2.279
ENSG00000122705 E021 698.9322358 9.963850e-04 4.019356e-02 1.551810e-01 9 36211603 36211603 1 + 2.852 2.829 -0.076
ENSG00000122705 E022 2078.4435343 1.330348e-03 3.829477e-02 1.503696e-01 9 36211604 36212061 458 + 3.319 3.306 -0.045
ENSG00000122705 E023 0.1614157 3.346449e-02 3.465784e-01   9 36263198 36263442 245 + 0.140 0.000 -8.643
ENSG00000122705 E024 4.7435116 5.340819e-03 1.457408e-01 3.559856e-01 9 36265421 36265574 154 + 0.606 0.830 0.921
ENSG00000122705 E025 0.0000000       9 36280520 36280637 118 +      
ENSG00000122705 E026 2.0474106 1.045497e-02 1.413319e-01 3.494742e-01 9 36284708 36284839 132 + 0.606 0.375 -1.150
ENSG00000122705 E027 1.8119318 1.609122e-01 7.572359e-02 2.362248e-01 9 36298739 36298903 165 + 0.140 0.552 2.752
ENSG00000122705 E028 1.8741557 5.654174e-02 6.003078e-01 7.704103e-01 9 36300655 36300825 171 + 0.400 0.504 0.534
ENSG00000122705 E029 3.8521326 7.321115e-03 5.562758e-01 7.407080e-01 9 36304067 36304781 715 + 0.607 0.709 0.436