ENSG00000122692

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397149 ENSG00000122692 HEK293_OSMI2_6hA HEK293_TMG_6hB SMU1 protein_coding protein_coding 60.57019 26.8199 88.56035 5.202439 2.334636 1.722982 5.458861 3.934406 5.970737 0.9730831 0.1924951 0.6005153 0.1046042 0.1430000 0.06743333 -0.07556667 0.0001832061 0.0001832061 FALSE TRUE
MSTRG.32519.3 ENSG00000122692 HEK293_OSMI2_6hA HEK293_TMG_6hB SMU1 protein_coding   60.57019 26.8199 88.56035 5.202439 2.334636 1.722982 20.097659 9.214191 26.546126 1.9243278 1.0917530 1.5255503 0.3576583 0.3411000 0.29976667 -0.04133333 0.5975651223 0.0001832061 FALSE TRUE
MSTRG.32519.4 ENSG00000122692 HEK293_OSMI2_6hA HEK293_TMG_6hB SMU1 protein_coding   60.57019 26.8199 88.56035 5.202439 2.334636 1.722982 9.967530 3.153515 16.307988 1.3806582 0.8406511 2.3668629 0.1415333 0.1107667 0.18443333 0.07366667 0.4933844899 0.0001832061 FALSE TRUE
MSTRG.32519.6 ENSG00000122692 HEK293_OSMI2_6hA HEK293_TMG_6hB SMU1 protein_coding   60.57019 26.8199 88.56035 5.202439 2.334636 1.722982 24.946506 10.517786 39.696987 1.5854671 2.3263972 1.9151908 0.3943125 0.4051667 0.44790000 0.04273333 0.8522573615 0.0001832061 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122692 E001 477.0659316 0.0006968461 5.371480e-41 9.704264e-38 9 33041765 33045953 4189 - 2.539 2.812 0.910
ENSG00000122692 E002 894.3701182 0.0005883243 9.012245e-07 2.594485e-05 9 33045954 33047391 1438 - 2.886 2.969 0.275
ENSG00000122692 E003 451.9116378 0.0009946884 1.576060e-01 3.731162e-01 9 33048106 33048258 153 - 2.624 2.596 -0.092
ENSG00000122692 E004 476.4788030 0.0002074339 9.361987e-01 9.703285e-01 9 33053123 33053290 168 - 2.637 2.642 0.016
ENSG00000122692 E005 396.9073870 0.0001432587 1.247442e-01 3.233377e-01 9 33056113 33056239 127 - 2.568 2.545 -0.077
ENSG00000122692 E006 444.6583163 0.0001742629 9.553352e-04 9.550147e-03 9 33056837 33056964 128 - 2.626 2.571 -0.184
ENSG00000122692 E007 407.1675771 0.0001524622 2.524956e-04 3.246730e-03 9 33057598 33057714 117 - 2.590 2.525 -0.216
ENSG00000122692 E008 306.1062376 0.0001692674 4.757435e-05 7.973962e-04 9 33060465 33060541 77 - 2.472 2.387 -0.286
ENSG00000122692 E009 212.7764350 0.0031463807 4.293198e-01 6.505134e-01 9 33060542 33060584 43 - 2.299 2.276 -0.077
ENSG00000122692 E010 378.8426238 0.0016401548 2.205915e-01 4.542093e-01 9 33062049 33062177 129 - 2.550 2.524 -0.087
ENSG00000122692 E011 356.5650975 0.0001849837 2.552882e-04 3.276931e-03 9 33068824 33068934 111 - 2.535 2.464 -0.235
ENSG00000122692 E012 381.8851313 0.0013540127 3.619207e-02 1.447572e-01 9 33071740 33071892 153 - 2.557 2.507 -0.167
ENSG00000122692 E013 479.8525500 0.0001902361 1.792297e-03 1.564901e-02 9 33073596 33073806 211 - 2.656 2.606 -0.168
ENSG00000122692 E014 268.4641039 0.0019084151 3.074058e-01 5.480106e-01 9 33076583 33076729 147 - 2.400 2.374 -0.088
ENSG00000122692 E015 1.4810038 0.0129325614 3.490086e-01 5.863990e-01 9 33076730 33076798 69 - 0.309 0.479 0.957
ENSG00000122692 E016 0.1779838 0.0354361332 1.000000e+00   9 33081315 33081369 55 - 0.082 0.001 -7.319