ENSG00000122591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409763 ENSG00000122591 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126A protein_coding protein_coding 12.96358 3.167746 23.86319 0.113224 0.6898481 2.909316 1.1116456 0.8947492 1.07361357 0.4766028 0.33413456 0.2602606 0.18575833 0.29380000 0.04426667 -0.24953333 0.72868425 0.02866375 FALSE TRUE
ENST00000409923 ENSG00000122591 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126A protein_coding protein_coding 12.96358 3.167746 23.86319 0.113224 0.6898481 2.909316 4.2554667 0.6740894 7.80107823 0.3771408 0.69029053 3.5132649 0.26500833 0.20920000 0.32590000 0.11670000 0.79642856 0.02866375 FALSE TRUE
ENST00000440481 ENSG00000122591 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126A protein_coding protein_coding 12.96358 3.167746 23.86319 0.113224 0.6898481 2.909316 1.8100688 0.5547748 2.79834295 0.2286976 0.09220504 2.3139715 0.17590417 0.17386667 0.11743333 -0.05643333 0.90216774 0.02866375 FALSE TRUE
ENST00000681079 ENSG00000122591 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126A protein_coding nonsense_mediated_decay 12.96358 3.167746 23.86319 0.113224 0.6898481 2.909316 0.1516461 0.4220306 0.04855765 0.1842924 0.04855765 -2.8832040 0.02510833 0.13016667 0.00200000 -0.12816667 0.02866375 0.02866375 TRUE TRUE
ENST00000681237 ENSG00000122591 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126A protein_coding nonsense_mediated_decay 12.96358 3.167746 23.86319 0.113224 0.6898481 2.909316 1.6617175 0.2760457 4.48068836 0.1889135 1.14154004 3.9726191 0.08194583 0.08430000 0.18640000 0.10210000 0.61144181 0.02866375 FALSE TRUE
ENST00000681766 ENSG00000122591 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126A protein_coding protein_coding 12.96358 3.167746 23.86319 0.113224 0.6898481 2.909316 0.6174889 0.0000000 1.51091898 0.0000000 0.77005526 7.2487995 0.05721250 0.00000000 0.06420000 0.06420000 0.59380178 0.02866375 FALSE TRUE
MSTRG.29563.7 ENSG00000122591 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM126A protein_coding   12.96358 3.167746 23.86319 0.113224 0.6898481 2.909316 2.3206397 0.1529838 4.67058624 0.1529838 1.03375219 4.8438887 0.12297917 0.04856667 0.19723333 0.14866667 0.30515404 0.02866375 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122591 E001 0.6957271 0.0196823120 5.868706e-02   7 22889371 22889693 323 - 0.091 0.444 2.927
ENSG00000122591 E002 0.1308682 0.0326491905 4.266059e-02   7 22890935 22891149 215 - 0.000 0.276 13.797
ENSG00000122591 E003 0.2735028 0.0274424043 1.442043e-01   7 22920232 22920325 94 - 0.048 0.276 2.923
ENSG00000122591 E004 16.5475567 0.0434832694 5.989581e-04 0.0065683103 7 22934211 22940971 6761 - 0.981 1.441 1.633
ENSG00000122591 E005 0.1614157 0.0337385006 7.358022e-01   7 22940972 22941083 112 - 0.048 0.000 -10.792
ENSG00000122591 E006 0.1614157 0.0337385006 7.358022e-01   7 22941084 22941165 82 - 0.048 0.000 -10.792
ENSG00000122591 E007 0.1426347 0.0323650226 7.345091e-01   7 22941166 22941268 103 - 0.048 0.000 -10.804
ENSG00000122591 E008 8.4359388 0.0036740755 4.146272e-03 0.0299732853 7 22941269 22941339 71 - 0.746 1.128 1.445
ENSG00000122591 E009 12.1673630 0.0031488804 1.090660e-02 0.0619728365 7 22941340 22941367 28 - 0.898 1.207 1.127
ENSG00000122591 E010 29.4001830 0.0401145689 2.059905e-03 0.0174604026 7 22941368 22941823 456 - 1.230 1.617 1.340
ENSG00000122591 E011 400.0487786 0.0004452154 9.890146e-06 0.0002077138 7 22941824 22944275 2452 - 2.428 2.309 -0.397
ENSG00000122591 E012 72.9081221 0.0005631023 3.147614e-01 0.5549194835 7 22944276 22944508 233 - 1.691 1.631 -0.205
ENSG00000122591 E013 48.9681081 0.0013494427 8.750520e-01 0.9387216929 7 22944509 22944650 142 - 1.514 1.506 -0.025
ENSG00000122591 E014 278.0312017 0.0017676349 5.413095e-03 0.0367648394 7 22944651 22945571 921 - 2.269 2.170 -0.330
ENSG00000122591 E015 164.3326336 0.0034656634 2.749937e-01 0.5149948724 7 22945572 22945982 411 - 2.026 2.086 0.200
ENSG00000122591 E016 118.4286595 0.0038559294 4.579560e-01 0.6717253163 7 22945983 22946163 181 - 1.894 1.857 -0.125
ENSG00000122591 E017 28.0722599 0.0011953055 5.959559e-01 0.7677085171 7 22946952 22947032 81 - 1.277 1.331 0.190
ENSG00000122591 E018 54.7661654 0.0007885145 2.778387e-01 0.5179014111 7 22947033 22947247 215 - 1.553 1.631 0.265
ENSG00000122591 E019 117.8791934 0.0046424167 1.020157e-01 0.2853903104 7 22960256 22960415 160 - 1.897 1.796 -0.341
ENSG00000122591 E020 0.2027342 0.0387049505 4.231901e-02   7 22960926 22961048 123 - 0.000 0.277 13.730
ENSG00000122591 E021 55.9001025 0.0140419287 8.894792e-01 0.9464404005 7 22961235 22961268 34 - 1.572 1.554 -0.062
ENSG00000122591 E022 65.5863998 0.0007462341 9.315684e-01 0.9678996558 7 22961269 22961322 54 - 1.640 1.649 0.032
ENSG00000122591 E023 82.2591625 0.0030668774 6.786456e-01 0.8218556333 7 22964415 22964531 117 - 1.734 1.762 0.095
ENSG00000122591 E024 76.1764209 0.0005681491 4.532090e-01 0.6681074156 7 22976210 22976305 96 - 1.708 1.666 -0.145
ENSG00000122591 E025 1.7423305 0.0118101559 8.031709e-01 0.8981693032 7 22976306 22976692 387 - 0.336 0.276 -0.396
ENSG00000122591 E026 58.7324301 0.0008874328 2.701775e-01 0.5101609540 7 22976693 22976768 76 - 1.604 1.530 -0.255
ENSG00000122591 E027 44.3909488 0.0035840661 1.454617e-01 0.3555988359 7 22976769 22976808 40 - 1.488 1.365 -0.425
ENSG00000122591 E028 0.0000000       7 22976809 22976858 50 -      
ENSG00000122591 E029 53.0824718 0.0008076939 2.950050e-02 0.1258791475 7 22977341 22977421 81 - 1.568 1.398 -0.583
ENSG00000122591 E030 2.2038818 0.2284060290 1.830906e-02 0.0900593392 7 22978164 22978268 105 - 0.260 0.817 2.763
ENSG00000122591 E031 68.8722390 0.0005587043 9.304571e-01 0.9672213845 7 22978269 22978404 136 - 1.659 1.657 -0.005
ENSG00000122591 E032 50.3921800 0.0008812115 1.717040e-01 0.3928137423 7 22978405 22978448 44 - 1.513 1.613 0.340
ENSG00000122591 E033 0.3393995 0.0274424043 1.000000e+00   7 22980297 22980320 24 - 0.091 0.000 -11.845
ENSG00000122591 E034 2.3150820 0.0339955833 5.470770e-01 0.7342254389 7 22980321 22981663 1343 - 0.420 0.276 -0.874
ENSG00000122591 E035 4.4086282 0.0057853252 6.873775e-01 0.8274229932 7 22981664 22983943 2280 - 0.581 0.658 0.339
ENSG00000122591 E036 39.4406250 0.0010374853 1.351055e-01 0.3398610028 7 22983944 22983948 5 - 1.410 1.530 0.413
ENSG00000122591 E037 68.7625265 0.0007157712 2.859422e-02 0.1231320019 7 22983949 22984045 97 - 1.642 1.776 0.453
ENSG00000122591 E038 0.2735028 0.0274424043 1.442043e-01   7 22985548 22985735 188 - 0.048 0.276 2.923
ENSG00000122591 E039 70.0248359 0.0014797319 7.345502e-04 0.0077379522 7 22991061 22991139 79 - 1.641 1.841 0.677
ENSG00000122591 E040 65.0065138 0.0007958844 2.678773e-03 0.0214512801 7 23013925 23014130 206 - 1.612 1.794 0.618