ENSG00000122515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265346 ENSG00000122515 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ2 protein_coding protein_coding 32.99189 48.37215 24.44823 5.29039 1.488813 -0.9841547 7.5314965 16.438476 3.0605191 3.6671165 1.6558204 -2.4213995 0.21328750 0.33216667 0.12043333 -0.211733333 0.67855878 0.02940681 FALSE  
ENST00000309315 ENSG00000122515 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ2 protein_coding protein_coding 32.99189 48.37215 24.44823 5.29039 1.488813 -0.9841547 3.2307804 7.635853 0.8641776 2.2785889 0.8641776 -3.1286791 0.09875417 0.15136667 0.03803333 -0.113333333 0.23660459 0.02940681 FALSE  
ENST00000441627 ENSG00000122515 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ2 protein_coding protein_coding 32.99189 48.37215 24.44823 5.29039 1.488813 -0.9841547 0.9851727 0.000000 2.5655872 0.0000000 1.2837775 8.0087576 0.03075833 0.00000000 0.10223333 0.102233333 0.19974152 0.02940681 FALSE  
ENST00000463931 ENSG00000122515 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ2 protein_coding processed_transcript 32.99189 48.37215 24.44823 5.29039 1.488813 -0.9841547 3.8849541 3.144796 1.4340046 0.1983250 0.2599575 -1.1274712 0.10456667 0.06606667 0.05893333 -0.007133333 0.92304909 0.02940681 FALSE  
ENST00000478045 ENSG00000122515 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ2 protein_coding retained_intron 32.99189 48.37215 24.44823 5.29039 1.488813 -0.9841547 2.5171921 3.005997 2.7067554 1.3391259 0.3897669 -0.1507502 0.08244167 0.06940000 0.10970000 0.040300000 0.63505750 0.02940681 FALSE  
MSTRG.29816.10 ENSG00000122515 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ2 protein_coding   32.99189 48.37215 24.44823 5.29039 1.488813 -0.9841547 2.3996871 2.815517 0.8021387 1.0311504 0.3133989 -1.7987170 0.07142917 0.05493333 0.03453333 -0.020400000 0.78876719 0.02940681 FALSE  
MSTRG.29816.7 ENSG00000122515 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ2 protein_coding   32.99189 48.37215 24.44823 5.29039 1.488813 -0.9841547 3.8595415 4.922371 4.5252903 0.8998032 0.2057721 -0.1210865 0.12252083 0.10013333 0.18623333 0.086100000 0.02940681 0.02940681 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122515 E001 0.2922838 0.0260886152 4.908247e-01   7 44748544 44748564 21 + 0.182 0.079 -1.380
ENSG00000122515 E002 0.5540201 0.2447365824 1.000000e+00   7 44748565 44748567 3 + 0.182 0.198 0.146
ENSG00000122515 E003 1.1966622 0.0807128363 5.472082e-01   7 44748568 44748571 4 + 0.409 0.297 -0.672
ENSG00000122515 E004 3.9948871 0.0067786050 9.984728e-01 1.000000e+00 7 44748572 44748580 9 + 0.667 0.663 -0.017
ENSG00000122515 E005 7.9415432 0.0040610301 5.857296e-01 7.607559e-01 7 44748581 44748631 51 + 0.860 0.924 0.245
ENSG00000122515 E006 0.0000000       7 44748847 44748854 8 +      
ENSG00000122515 E007 0.0000000       7 44748855 44748861 7 +      
ENSG00000122515 E008 3.8498520 0.0066502263 4.315480e-01 6.523774e-01 7 44748862 44748932 71 + 0.556 0.681 0.546
ENSG00000122515 E009 21.3456596 0.0019393066 6.386826e-01 7.961463e-01 7 44748933 44748961 29 + 1.339 1.296 -0.148
ENSG00000122515 E010 39.0697758 0.0224878540 7.357237e-01 8.577600e-01 7 44748962 44748991 30 + 1.531 1.566 0.120
ENSG00000122515 E011 8.6220393 0.0058490099 2.392781e-02 1.088766e-01 7 44749815 44749980 166 + 1.113 0.846 -0.994
ENSG00000122515 E012 6.0238766 0.0047350368 4.206816e-01 6.441851e-01 7 44750972 44751091 120 + 0.890 0.778 -0.434
ENSG00000122515 E013 0.8563349 0.0181925266 6.836710e-01   7 44756179 44756187 9 + 0.182 0.256 0.623
ENSG00000122515 E014 56.9252867 0.0033303023 9.786052e-01 9.910885e-01 7 44756188 44756204 17 + 1.720 1.718 -0.006
ENSG00000122515 E015 137.4405932 0.0016584266 3.577113e-01 5.939112e-01 7 44756205 44756299 95 + 2.124 2.085 -0.133
ENSG00000122515 E016 209.3155354 0.0014508257 1.029281e-01 2.870066e-01 7 44756425 44756539 115 + 2.317 2.260 -0.191
ENSG00000122515 E017 16.7661570 0.2260785241 2.178910e-01 4.509084e-01 7 44756540 44756946 407 + 1.347 1.132 -0.757
ENSG00000122515 E018 134.6950949 0.0003804337 6.328288e-01 7.921695e-01 7 44756947 44756974 28 + 2.103 2.082 -0.072
ENSG00000122515 E019 171.9271058 0.0019396800 6.373800e-01 7.952932e-01 7 44756975 44757042 68 + 2.208 2.185 -0.079
ENSG00000122515 E020 201.6063367 0.0020164719 4.591082e-01 6.725421e-01 7 44757043 44757149 107 + 2.246 2.265 0.065
ENSG00000122515 E021 208.4835662 0.0024303183 9.097400e-03 5.426010e-02 7 44757378 44757561 184 + 2.208 2.298 0.299
ENSG00000122515 E022 238.4195945 0.0031575378 2.570660e-01 4.958845e-01 7 44757848 44758108 261 + 2.310 2.341 0.104
ENSG00000122515 E023 222.3538626 0.0003236329 1.120528e-02 6.321744e-02 7 44759281 44759460 180 + 2.259 2.322 0.211
ENSG00000122515 E024 28.0987589 0.1722099645 7.081153e-03 4.499439e-02 7 44759734 44759950 217 + 1.726 1.198 -1.822
ENSG00000122515 E025 31.2566753 0.2771899950 3.507353e-02 1.417649e-01 7 44759951 44760150 200 + 1.734 1.285 -1.544
ENSG00000122515 E026 51.0652358 0.0049177234 4.948129e-01 6.972938e-01 7 44760151 44760228 78 + 1.707 1.654 -0.180
ENSG00000122515 E027 27.9755512 0.2602679385 6.434279e-02 2.124531e-01 7 44760229 44760424 196 + 1.638 1.286 -1.214
ENSG00000122515 E028 307.2705714 0.0002241832 2.731443e-01 5.130015e-01 7 44760425 44760593 169 + 2.466 2.435 -0.103
ENSG00000122515 E029 14.6712839 0.0308093400 1.744756e-01 3.964867e-01 7 44761422 44761448 27 + 1.279 1.094 -0.660
ENSG00000122515 E030 294.8513041 0.0002206753 1.049324e-02 6.022689e-02 7 44761449 44761593 145 + 2.472 2.408 -0.214
ENSG00000122515 E031 21.0898065 0.1229941832 6.532105e-01 8.055580e-01 7 44761594 44761694 101 + 1.336 1.281 -0.194
ENSG00000122515 E032 282.4662445 0.0002395310 3.426913e-01 5.803957e-01 7 44761695 44761807 113 + 2.429 2.401 -0.093
ENSG00000122515 E033 238.8656676 0.0009190069 1.646791e-01 3.835992e-01 7 44761808 44761905 98 + 2.370 2.324 -0.152
ENSG00000122515 E034 227.0949648 0.0003106348 1.836766e-02 9.024829e-02 7 44762881 44762986 106 + 2.363 2.297 -0.222
ENSG00000122515 E035 302.5509677 0.0001871103 7.447514e-01 8.635231e-01 7 44763256 44763413 158 + 2.436 2.437 0.005
ENSG00000122515 E036 0.3206185 0.0244411696 4.762747e-02   7 44763689 44763750 62 + 0.310 0.000 -11.859
ENSG00000122515 E037 221.2312823 0.0007543274 8.139725e-01 9.046397e-01 7 44764419 44764486 68 + 2.309 2.295 -0.047
ENSG00000122515 E038 212.1785360 0.0009800187 5.451335e-01 7.327690e-01 7 44764941 44765009 69 + 2.274 2.287 0.043
ENSG00000122515 E039 253.8449486 0.0008787698 1.252838e-03 1.181271e-02 7 44765335 44765579 245 + 2.298 2.385 0.290
ENSG00000122515 E040 12.5850751 0.1424280718 4.309437e-02 1.628220e-01 7 44765580 44765710 131 + 1.341 0.937 -1.449
ENSG00000122515 E041 8.4083823 0.0963947075 2.911492e-03 2.286843e-02 7 44765711 44765743 33 + 1.243 0.716 -1.976
ENSG00000122515 E042 21.5235071 0.2100531251 1.368143e-02 7.309117e-02 7 44765744 44765966 223 + 1.607 1.098 -1.772
ENSG00000122515 E043 15.6191606 0.1743497682 6.288685e-02 2.092118e-01 7 44765967 44766056 90 + 1.398 1.044 -1.256
ENSG00000122515 E044 12.3702030 0.1643676644 3.023918e-01 5.429707e-01 7 44766057 44766163 107 + 1.204 1.021 -0.659
ENSG00000122515 E045 229.8371839 0.0037330889 2.510894e-02 1.125561e-01 7 44766164 44766333 170 + 2.258 2.335 0.258
ENSG00000122515 E046 409.5036922 0.0002792607 3.613828e-03 2.700587e-02 7 44766421 44766663 243 + 2.528 2.580 0.176
ENSG00000122515 E047 1211.8327938 0.0002146745 8.372577e-11 6.029924e-09 7 44767516 44768697 1182 + 2.985 3.057 0.236
ENSG00000122515 E048 175.7239002 0.0006425416 2.213432e-03 1.848224e-02 7 44768698 44769114 417 + 2.270 2.171 -0.332
ENSG00000122515 E049 105.9503019 0.0023283217 6.536179e-01 8.058592e-01 7 44769115 44769454 340 + 2.002 1.973 -0.097
ENSG00000122515 E050 158.2333313 0.0003092854 5.668578e-06 1.286112e-04 7 44769455 44769881 427 + 2.256 2.114 -0.477