ENSG00000122299

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355758 ENSG00000122299 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H7A protein_coding protein_coding 21.78791 13.63524 32.35758 1.028987 2.36534 1.246151 12.185043 6.4866589 17.549194 1.2461220 0.86234561 1.4344568 0.51656250 0.47466667 0.54460000 0.06993333 0.845574907 0.002566729 FALSE TRUE
ENST00000570862 ENSG00000122299 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H7A protein_coding retained_intron 21.78791 13.63524 32.35758 1.028987 2.36534 1.246151 1.460353 0.8347886 2.674969 0.3586964 0.03230633 1.6682434 0.06352083 0.06486667 0.08373333 0.01886667 0.820306801 0.002566729   FALSE
ENST00000571405 ENSG00000122299 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H7A protein_coding nonsense_mediated_decay 21.78791 13.63524 32.35758 1.028987 2.36534 1.246151 2.323747 2.5008111 1.311151 0.5500551 0.37562969 -0.9263581 0.15825833 0.17916667 0.03916667 -0.14000000 0.002566729 0.002566729 FALSE TRUE
ENST00000575984 ENSG00000122299 HEK293_OSMI2_6hA HEK293_TMG_6hB ZC3H7A protein_coding protein_coding 21.78791 13.63524 32.35758 1.028987 2.36534 1.246151 1.386037 0.9643503 2.170429 0.3008957 0.01882307 1.1620993 0.06794167 0.07480000 0.06790000 -0.00690000 1.000000000 0.002566729 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122299 E001 0.1308682 0.0326491905 2.454865e-01   16 11750586 11750590 5 - 0.000 0.164 11.933
ENSG00000122299 E002 0.4458772 0.0217681645 2.457833e-01   16 11750591 11750592 2 - 0.088 0.283 2.027
ENSG00000122299 E003 0.5885118 0.0373946965 5.023412e-01   16 11750593 11750594 2 - 0.162 0.283 1.029
ENSG00000122299 E004 1.1967145 0.1278701658 6.251800e-02   16 11750595 11750596 2 - 0.161 0.525 2.390
ENSG00000122299 E005 379.8462143 0.0027475513 6.566546e-07 1.971973e-05 16 11750597 11751506 910 - 2.499 2.650 0.503
ENSG00000122299 E006 162.8931961 0.0013539473 2.842717e-01 5.247891e-01 16 11752669 11752832 164 - 2.177 2.221 0.150
ENSG00000122299 E007 1.7244364 0.1166492508 4.132850e-02 1.581863e-01 16 11752833 11753162 330 - 0.225 0.632 2.269
ENSG00000122299 E008 134.1604686 0.0051907200 3.432255e-01 5.808950e-01 16 11756237 11756321 85 - 2.091 2.148 0.188
ENSG00000122299 E009 80.0996031 0.0006482804 1.223079e-02 6.736455e-02 16 11756322 11756328 7 - 1.849 1.962 0.382
ENSG00000122299 E010 114.6248433 0.0008581252 7.645811e-02 2.376529e-01 16 11756329 11756370 42 - 2.015 2.089 0.249
ENSG00000122299 E011 156.0681521 0.0003265263 5.880886e-02 2.000821e-01 16 11758431 11758539 109 - 2.150 2.216 0.222
ENSG00000122299 E012 51.9340739 0.1153568209 9.941579e-01 9.986566e-01 16 11758540 11759850 1311 - 1.679 1.733 0.183
ENSG00000122299 E013 96.3781997 0.0011312084 4.818965e-02 1.754467e-01 16 11761406 11761467 62 - 1.935 2.024 0.299
ENSG00000122299 E014 89.1226469 0.0004742951 7.139519e-03 4.527801e-02 16 11761468 11761511 44 - 1.894 2.008 0.383
ENSG00000122299 E015 10.0289682 0.1189125529 5.995303e-01 7.698953e-01 16 11761512 11761662 151 - 1.040 0.973 -0.247
ENSG00000122299 E016 83.8225829 0.0006060810 1.481193e-01 3.596446e-01 16 11761910 11761947 38 - 1.885 1.953 0.231
ENSG00000122299 E017 104.2036962 0.0005179092 6.859800e-01 8.264883e-01 16 11761948 11762043 96 - 1.993 2.018 0.083
ENSG00000122299 E018 97.5354874 0.0014119092 7.421818e-01 8.617604e-01 16 11762671 11762747 77 - 1.963 1.984 0.072
ENSG00000122299 E019 8.7438824 0.2390622021 8.770492e-01 9.397457e-01 16 11762748 11763229 482 - 0.917 1.050 0.493
ENSG00000122299 E020 145.0378959 0.0003057759 7.568314e-03 4.734322e-02 16 11763478 11763659 182 - 2.109 2.201 0.306
ENSG00000122299 E021 0.8567829 0.1734686753 1.243188e-01   16 11764965 11765052 88 - 0.332 0.000 -12.298
ENSG00000122299 E022 87.2392021 0.0005941319 1.033157e-01 2.877661e-01 16 11765053 11765153 101 - 1.897 1.973 0.253
ENSG00000122299 E023 48.0829310 0.0053778880 4.081743e-01 6.346058e-01 16 11765489 11765516 28 - 1.684 1.643 -0.137
ENSG00000122299 E024 74.9142556 0.0007198339 5.642756e-01 7.462986e-01 16 11765517 11765574 58 - 1.863 1.848 -0.049
ENSG00000122299 E025 106.6110793 0.0003774270 9.002479e-01 9.519855e-01 16 11765575 11765685 111 - 2.008 2.014 0.020
ENSG00000122299 E026 63.1671442 0.0006900968 5.120782e-01 7.095112e-01 16 11767417 11767436 20 - 1.794 1.774 -0.067
ENSG00000122299 E027 138.8612908 0.0003089646 3.989138e-02 1.544272e-01 16 11767437 11767578 142 - 2.142 2.087 -0.185
ENSG00000122299 E028 136.6852128 0.0003434802 2.828170e-03 2.236187e-02 16 11768315 11768501 187 - 2.143 2.056 -0.292
ENSG00000122299 E029 1.4346959 0.0122841821 9.977144e-01 1.000000e+00 16 11768502 11768521 20 - 0.372 0.377 0.029
ENSG00000122299 E030 63.0791854 0.0005918123 1.195309e-01 3.150837e-01 16 11769031 11769095 65 - 1.806 1.743 -0.215
ENSG00000122299 E031 130.0986749 0.0003941477 3.840788e-04 4.579782e-03 16 11770783 11770987 205 - 2.131 2.021 -0.367
ENSG00000122299 E032 155.6749191 0.0004245059 1.248325e-03 1.177873e-02 16 11774236 11774519 284 - 2.201 2.110 -0.302
ENSG00000122299 E033 60.1553749 0.0007641020 1.229705e-03 1.164968e-02 16 11774980 11775013 34 - 1.808 1.655 -0.518
ENSG00000122299 E034 1.7764959 0.2257897695 4.367996e-01 6.562942e-01 16 11775527 11775632 106 - 0.482 0.286 -1.127
ENSG00000122299 E035 55.6467362 0.0009623409 1.467610e-02 7.687898e-02 16 11776320 11776358 39 - 1.768 1.651 -0.397
ENSG00000122299 E036 90.8142242 0.0005030934 1.243161e-03 1.174309e-02 16 11776452 11776532 81 - 1.978 1.857 -0.407
ENSG00000122299 E037 58.9752658 0.0007119273 1.201435e-01 3.160630e-01 16 11776751 11776757 7 - 1.776 1.709 -0.227
ENSG00000122299 E038 102.1599730 0.0004021326 1.547441e-02 7.986600e-02 16 11776758 11776909 152 - 2.016 1.935 -0.272
ENSG00000122299 E039 59.9479078 0.0034550089 5.365626e-03 3.652424e-02 16 11779166 11779239 74 - 1.804 1.658 -0.494
ENSG00000122299 E040 46.3101922 0.0022065069 1.094226e-02 6.212381e-02 16 11779240 11779261 22 - 1.692 1.550 -0.481
ENSG00000122299 E041 53.6347985 0.0009210275 1.750980e-02 8.732431e-02 16 11779262 11779289 28 - 1.748 1.632 -0.391
ENSG00000122299 E042 64.9911940 0.0006540862 9.758901e-03 5.708283e-02 16 11779290 11779363 74 - 1.830 1.717 -0.383
ENSG00000122299 E043 50.8334539 0.0008012497 3.140393e-02 1.314966e-01 16 11781425 11781464 40 - 1.724 1.618 -0.358
ENSG00000122299 E044 56.2187884 0.0008224031 7.041303e-02 2.255214e-01 16 11782287 11782388 102 - 1.759 1.677 -0.280
ENSG00000122299 E045 0.5117739 0.0219969488 1.000000e+00   16 11782389 11782552 164 - 0.162 0.165 0.027
ENSG00000122299 E046 0.1723744 0.0369119671 2.435799e-01   16 11782864 11783034 171 - 0.000 0.165 11.973
ENSG00000122299 E047 11.7253397 0.0215773785 1.165349e-01 3.100179e-01 16 11796219 11796415 197 - 1.003 1.197 0.701
ENSG00000122299 E048 1.4147472 0.0127734794 9.883609e-01 9.959439e-01 16 11796416 11796527 112 - 0.372 0.377 0.025
ENSG00000122299 E049 0.3807181 0.0330277396 6.126833e-01   16 11796834 11797123 290 - 0.089 0.165 1.029
ENSG00000122299 E050 25.2098836 0.0014745460 4.294891e-01 6.506260e-01 16 11797124 11797258 135 - 1.369 1.435 0.231