ENSG00000122126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357121 ENSG00000122126 HEK293_OSMI2_6hA HEK293_TMG_6hB OCRL protein_coding protein_coding 24.20556 28.99634 20.76388 3.797032 0.4889458 -0.4815978 10.037377 12.268535 11.6948655 1.8800830 1.2993241 -0.0690300775 0.4244792 0.4205333 0.5620667 0.14153333 3.738703e-01 1.831674e-25 FALSE TRUE
ENST00000371113 ENSG00000122126 HEK293_OSMI2_6hA HEK293_TMG_6hB OCRL protein_coding protein_coding 24.20556 28.99634 20.76388 3.797032 0.4889458 -0.4815978 3.437403 3.539021 3.5386616 0.8776354 1.2812204 -0.0001460758 0.1505833 0.1186000 0.1713667 0.05276667 9.139337e-01 1.831674e-25 FALSE TRUE
ENST00000463271 ENSG00000122126 HEK293_OSMI2_6hA HEK293_TMG_6hB OCRL protein_coding processed_transcript 24.20556 28.99634 20.76388 3.797032 0.4889458 -0.4815978 5.100987 7.208526 0.2689283 1.1759402 0.0369177 -4.6937379058 0.1838958 0.2478000 0.0129000 -0.23490000 1.831674e-25 1.831674e-25   FALSE
MSTRG.34858.3 ENSG00000122126 HEK293_OSMI2_6hA HEK293_TMG_6hB OCRL protein_coding   24.20556 28.99634 20.76388 3.797032 0.4889458 -0.4815978 4.418677 4.873606 3.8587702 0.6625841 0.4981791 -0.3360718064 0.1908875 0.1699667 0.1869000 0.01693333 9.508248e-01 1.831674e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122126 E001 0.0000000       X 129539849 129539939 91 +      
ENSG00000122126 E002 0.7616940 0.0897079784 1.140300e-01   X 129540171 129540226 56 + 0.395 0.107 -2.413
ENSG00000122126 E003 5.7794615 0.0051895884 2.871941e-01 5.279593e-01 X 129540227 129540258 32 + 0.889 0.758 -0.511
ENSG00000122126 E004 11.7718782 0.0029648114 4.091179e-01 6.353445e-01 X 129540259 129540274 16 + 1.138 1.063 -0.268
ENSG00000122126 E005 27.4981423 0.0090103354 2.179478e-01 4.510023e-01 X 129540275 129540299 25 + 1.385 1.491 0.366
ENSG00000122126 E006 81.5339054 0.0144857563 5.097330e-01 7.077828e-01 X 129540300 129540478 179 + 1.880 1.932 0.178
ENSG00000122126 E007 35.8901616 0.0011111227 5.767625e-01 7.549608e-01 X 129540744 129540747 4 + 1.576 1.550 -0.088
ENSG00000122126 E008 72.3897177 0.0014334997 7.956582e-01 8.938293e-01 X 129540748 129540823 76 + 1.849 1.868 0.065
ENSG00000122126 E009 0.6294705 0.0220346385 1.893656e-01   X 129543469 129543978 510 + 0.327 0.106 -2.016
ENSG00000122126 E010 49.8147108 0.0009150971 7.896465e-01 8.903387e-01 X 129544958 129544972 15 + 1.689 1.710 0.071
ENSG00000122126 E011 71.9424458 0.0005906397 4.128014e-02 1.580574e-01 X 129544973 129545037 65 + 1.901 1.822 -0.266
ENSG00000122126 E012 61.0365009 0.0006878485 1.086190e-04 1.601494e-03 X 129548563 129548601 39 + 1.873 1.704 -0.573
ENSG00000122126 E013 0.5173834 0.0395908447 4.774753e-02   X 129549648 129549917 270 + 0.328 0.000 -10.236
ENSG00000122126 E014 0.7970432 0.0172367428 8.890733e-02   X 129553236 129553273 38 + 0.397 0.107 -2.427
ENSG00000122126 E015 15.6967680 0.1213549796 2.034160e-01 4.338346e-01 X 129553274 129554393 1120 + 1.043 1.315 0.972
ENSG00000122126 E016 2.2017888 0.0100472506 6.257228e-01 7.877026e-01 X 129554394 129554446 53 + 0.458 0.544 0.419
ENSG00000122126 E017 0.6238610 0.0198673664 7.575846e-01   X 129555675 129555743 69 + 0.243 0.192 -0.429
ENSG00000122126 E018 108.9239756 0.0003642230 1.454188e-04 2.044157e-03 X 129557325 129557435 111 + 2.100 1.978 -0.410
ENSG00000122126 E019 79.6582639 0.0004667157 1.318795e-02 7.120521e-02 X 129557861 129557950 90 + 1.947 1.855 -0.309
ENSG00000122126 E020 104.9672269 0.0005132231 5.689636e-02 1.957915e-01 X 129558633 129558753 121 + 2.047 1.987 -0.201
ENSG00000122126 E021 142.4797038 0.0002980763 2.115498e-03 1.784434e-02 X 129558840 129559001 162 + 2.193 2.108 -0.284
ENSG00000122126 E022 129.0745550 0.0017859613 4.038618e-03 2.938518e-02 X 129560550 129560651 102 + 2.157 2.060 -0.327
ENSG00000122126 E023 124.3759692 0.0135122620 4.018005e-02 1.551606e-01 X 129561179 129561243 65 + 2.156 2.034 -0.409
ENSG00000122126 E024 115.2234629 0.0090287277 1.010155e-03 9.988795e-03 X 129561244 129561293 50 + 2.149 1.973 -0.590
ENSG00000122126 E025 172.4644566 0.0112153137 5.253949e-03 3.595805e-02 X 129562384 129562500 117 + 2.313 2.161 -0.509
ENSG00000122126 E026 167.9845239 0.0012851843 5.211381e-04 5.866059e-03 X 129562599 129562786 188 + 2.277 2.175 -0.340
ENSG00000122126 E027 122.4067617 0.0004126271 3.759220e-02 1.485589e-01 X 129565772 129565883 112 + 2.118 2.058 -0.202
ENSG00000122126 E028 142.8603654 0.0048915466 3.350339e-01 5.736004e-01 X 129567254 129567363 110 + 2.169 2.139 -0.100
ENSG00000122126 E029 168.9254436 0.0005236901 3.371582e-01 5.755722e-01 X 129569264 129569399 136 + 2.232 2.212 -0.065
ENSG00000122126 E030 179.0082766 0.0004456169 7.934178e-02 2.434944e-01 X 129575140 129575250 111 + 2.267 2.226 -0.136
ENSG00000122126 E031 0.3150090 0.0273671288 8.218932e-01   X 129575654 129575719 66 + 0.138 0.107 -0.426
ENSG00000122126 E032 234.6246308 0.0033363793 9.923762e-02 2.804411e-01 X 129575897 129576062 166 + 2.389 2.342 -0.157
ENSG00000122126 E033 278.9274868 0.0014712311 2.221911e-02 1.033417e-01 X 129576317 129576552 236 + 2.467 2.416 -0.172
ENSG00000122126 E034 2.3549023 0.1163647886 1.777618e-01 4.007910e-01 X 129576553 129576765 213 + 0.642 0.383 -1.257
ENSG00000122126 E035 22.4471982 0.0015888264 7.915896e-01 8.913754e-01 X 129584344 129584367 24 + 1.363 1.351 -0.043
ENSG00000122126 E036 159.6821371 0.0130789211 9.939351e-01 9.985745e-01 X 129587002 129587118 117 + 2.195 2.205 0.033
ENSG00000122126 E037 142.7167201 0.0018850744 3.048184e-01 5.453961e-01 X 129588179 129588263 85 + 2.124 2.169 0.153
ENSG00000122126 E038 181.6946183 0.0017397759 4.617707e-01 6.743656e-01 X 129588886 129589013 128 + 2.236 2.269 0.110
ENSG00000122126 E039 5.8008582 0.0747992932 2.289342e-01 4.639079e-01 X 129589237 129589364 128 + 0.676 0.906 0.916
ENSG00000122126 E040 4.5759341 0.0243794009 2.113739e-01 4.434033e-01 X 129589589 129589844 256 + 0.601 0.802 0.832
ENSG00000122126 E041 162.9153908 0.0004063853 6.286258e-01 7.896505e-01 X 129589845 129589956 112 + 2.190 2.212 0.074
ENSG00000122126 E042 1641.3413186 0.0005112252 5.939303e-32 5.572543e-29 X 129590146 129592561 2416 + 3.123 3.260 0.456