ENSG00000122085

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391980 ENSG00000122085 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF4 protein_coding protein_coding 36.40819 28.71931 38.72402 1.413583 2.159262 0.4310781 11.053379 5.851703 12.868579 0.5893736 0.4429954 1.1355817 0.30021250 0.2029333 0.33560000 0.13266667 0.063132248 0.001241332 FALSE  
ENST00000406593 ENSG00000122085 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF4 protein_coding protein_coding 36.40819 28.71931 38.72402 1.413583 2.159262 0.4310781 6.615145 3.410270 7.303565 0.4433119 0.8509035 1.0964648 0.17757500 0.1203333 0.18736667 0.06703333 0.344502674 0.001241332 FALSE  
ENST00000455202 ENSG00000122085 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF4 protein_coding processed_transcript 36.40819 28.71931 38.72402 1.413583 2.159262 0.4310781 4.552450 5.489460 3.622234 0.2013389 0.2793468 -0.5984329 0.12974583 0.1918000 0.09396667 -0.09783333 0.001241332 0.001241332    
MSTRG.20177.8 ENSG00000122085 HEK293_OSMI2_6hA HEK293_TMG_6hB MTERF4 protein_coding   36.40819 28.71931 38.72402 1.413583 2.159262 0.4310781 3.135191 3.388859 2.946717 0.9450781 0.5863611 -0.2010545 0.08724583 0.1172333 0.07566667 -0.04156667 0.787248016 0.001241332    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122085 E001 35.3002955 0.3704544606 5.641359e-02 1.945994e-01 2 241072169 241075053 2885 - 1.258 1.729 1.620
ENSG00000122085 E002 29.9474762 0.0837718815 2.353349e-01 4.712612e-01 2 241075054 241075649 596 - 1.402 1.566 0.563
ENSG00000122085 E003 15.1606183 0.0471664654 5.905952e-01 7.641125e-01 2 241075650 241075657 8 - 1.173 1.253 0.283
ENSG00000122085 E004 21.0515879 0.0459890727 4.355000e-01 6.553616e-01 2 241075658 241075682 25 - 1.288 1.397 0.378
ENSG00000122085 E005 0.6542209 0.0201748362 9.372366e-01   2 241087094 241087098 5 - 0.219 0.213 -0.048
ENSG00000122085 E006 7.4294748 0.0040782725 1.855343e-02 9.090331e-02 2 241087099 241087203 105 - 0.747 1.048 1.146
ENSG00000122085 E007 6.6629791 0.0048474363 7.069302e-03 4.494754e-02 2 241087204 241087224 21 - 0.663 1.022 1.401
ENSG00000122085 E008 268.8797117 0.0038029954 7.884131e-13 8.234359e-11 2 241087225 241088904 1680 - 2.269 2.543 0.912
ENSG00000122085 E009 36.5444086 0.0043717459 1.086863e-02 6.181156e-02 2 241088905 241089040 136 - 1.460 1.651 0.650
ENSG00000122085 E010 39.9042336 0.0010450343 5.777693e-04 6.379203e-03 2 241089041 241089168 128 - 1.484 1.701 0.738
ENSG00000122085 E011 24.7821941 0.0014865402 7.217823e-02 2.291725e-01 2 241089169 241089187 19 - 1.329 1.476 0.507
ENSG00000122085 E012 52.2219832 0.0061118482 2.409650e-02 1.093621e-01 2 241089188 241089224 37 - 1.641 1.796 0.525
ENSG00000122085 E013 67.3042335 0.0014553387 4.815459e-04 5.508762e-03 2 241089225 241089266 42 - 1.733 1.912 0.605
ENSG00000122085 E014 49.7153192 0.0010774480 1.308904e-04 1.872164e-03 2 241089267 241089272 6 - 1.577 1.794 0.739
ENSG00000122085 E015 82.3070966 0.0073545354 9.268905e-04 9.312534e-03 2 241089273 241089365 93 - 1.803 2.008 0.690
ENSG00000122085 E016 54.1955729 0.0417298859 4.096048e-02 1.572091e-01 2 241089980 241090005 26 - 1.612 1.837 0.763
ENSG00000122085 E017 61.0516805 0.0396878057 3.375290e-02 1.381995e-01 2 241090006 241090044 39 - 1.661 1.888 0.767
ENSG00000122085 E018 1.8853747 0.0106298178 8.898161e-01 9.465994e-01 2 241090278 241090302 25 - 0.472 0.463 -0.048
ENSG00000122085 E019 6.0610899 0.0139504191 8.465065e-01 9.230328e-01 2 241090303 241090449 147 - 0.819 0.866 0.185
ENSG00000122085 E020 6.2473101 0.0523648042 5.927381e-01 7.654447e-01 2 241091895 241092114 220 - 0.815 0.904 0.346
ENSG00000122085 E021 57.9904838 0.5803220448 1.479137e-01 3.593136e-01 2 241094277 241094405 129 - 1.528 1.918 1.320
ENSG00000122085 E022 27.9615092 0.3529050048 1.320572e-01 3.350396e-01 2 241094406 241094429 24 - 1.260 1.593 1.150
ENSG00000122085 E023 20.1691851 0.2800176694 1.828739e-01 4.077062e-01 2 241094430 241094432 3 - 1.172 1.435 0.921
ENSG00000122085 E024 10.7070812 0.2497838300 2.726521e-01 5.125088e-01 2 241094433 241094596 164 - 0.885 1.193 1.127
ENSG00000122085 E025 27.6473775 0.4968775335 3.535021e-01 5.904439e-01 2 241094597 241095129 533 - 1.313 1.560 0.853
ENSG00000122085 E026 27.6067607 0.5958990127 6.036898e-01 7.726078e-01 2 241095130 241095570 441 - 1.406 1.501 0.327
ENSG00000122085 E027 96.8567120 0.0005887577 1.733159e-06 4.600347e-05 2 241095571 241095868 298 - 2.062 1.910 -0.511
ENSG00000122085 E028 184.1385947 0.0069855035 8.745903e-08 3.288874e-06 2 241095869 241096139 271 - 2.363 2.149 -0.715
ENSG00000122085 E029 179.1446610 0.0087561764 2.030095e-07 6.988788e-06 2 241096140 241096392 253 - 2.358 2.128 -0.768
ENSG00000122085 E030 71.1696901 0.0007631630 1.384320e-10 9.531944e-09 2 241096393 241096438 46 - 1.969 1.714 -0.858
ENSG00000122085 E031 4.7685743 0.0881453111 2.211284e-01 4.548478e-01 2 241096601 241096713 113 - 0.859 0.649 -0.849
ENSG00000122085 E032 10.9420043 0.0738988106 2.955629e-01 5.360707e-01 2 241096926 241097186 261 - 1.137 1.012 -0.456
ENSG00000122085 E033 5.3219694 0.0845398400 2.405954e-01 4.772591e-01 2 241097187 241097242 56 - 0.878 0.712 -0.657
ENSG00000122085 E034 167.5349921 0.0005649993 4.637544e-07 1.449589e-05 2 241097243 241097427 185 - 2.284 2.165 -0.400
ENSG00000122085 E035 3.4581409 0.0071905617 5.445527e-01 7.323298e-01 2 241099168 241099395 228 - 0.693 0.620 -0.312
ENSG00000122085 E036 41.6515037 0.0373886482 2.444752e-02 1.105041e-01 2 241099396 241099398 3 - 1.716 1.515 -0.685
ENSG00000122085 E037 181.7212886 0.0049672184 1.488726e-10 1.019024e-08 2 241099399 241099894 496 - 2.364 2.131 -0.782
ENSG00000122085 E038 2.0282991 0.0106214496 3.131118e-01 5.533675e-01 2 241101164 241101221 58 - 0.364 0.549 0.955
ENSG00000122085 E039 0.1614157 0.0323649300 4.515536e-01   2 241102140 241102252 113 - 0.123 0.000 -8.565
ENSG00000122085 E040 85.0814918 0.0067950963 1.715759e-01 3.926202e-01 2 241102253 241102332 80 - 1.961 1.912 -0.164