ENSG00000122033

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381120 ENSG00000122033 HEK293_OSMI2_6hA HEK293_TMG_6hB MTIF3 protein_coding protein_coding 29.00637 21.63276 38.27026 1.560049 1.668814 0.8227159 20.224354 14.458335 27.0974244 1.4482617 1.7845225 0.9057892 0.7057542 0.66810000 0.7097333 0.04163333 9.124765e-01 3.231119e-07 FALSE TRUE
ENST00000405591 ENSG00000122033 HEK293_OSMI2_6hA HEK293_TMG_6hB MTIF3 protein_coding protein_coding 29.00637 21.63276 38.27026 1.560049 1.668814 0.8227159 2.338382 2.058948 5.1813520 0.5650331 2.8413463 1.3272130 0.0738250 0.09326667 0.1336333 0.04036667 1.000000e+00 3.231119e-07 FALSE TRUE
MSTRG.8519.3 ENSG00000122033 HEK293_OSMI2_6hA HEK293_TMG_6hB MTIF3 protein_coding   29.00637 21.63276 38.27026 1.560049 1.668814 0.8227159 1.295895 1.557773 0.5557988 0.1492085 0.1096448 -1.4703554 0.0485875 0.07190000 0.0144000 -0.05750000 3.231119e-07 3.231119e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000122033 E001 2.918085 0.0153698105 0.304437660 0.54500766 13 27435643 27435649 7 - 0.509 0.675 0.743
ENSG00000122033 E002 10.887340 0.2468494540 0.356459038 0.59291592 13 27435650 27435683 34 - 1.005 1.150 0.526
ENSG00000122033 E003 131.156670 0.1935570919 0.315626912 0.55562625 13 27435684 27435858 175 - 2.065 2.178 0.381
ENSG00000122033 E004 117.078019 0.0286269403 0.482793588 0.68895807 13 27435859 27435893 35 - 2.050 2.095 0.149
ENSG00000122033 E005 79.676616 0.0025855383 0.881770344 0.94228361 13 27437116 27437116 1 - 1.908 1.906 -0.006
ENSG00000122033 E006 111.922827 0.0016547867 0.267003203 0.50661756 13 27437117 27437144 28 - 2.032 2.079 0.157
ENSG00000122033 E007 99.403668 0.0004235740 0.514585047 0.71140000 13 27437145 27437149 5 - 1.989 2.019 0.102
ENSG00000122033 E008 188.032655 0.0024774650 0.624344602 0.78689698 13 27437150 27437268 119 - 2.281 2.270 -0.037
ENSG00000122033 E009 101.999579 0.0004279740 0.113731428 0.30534856 13 27437269 27437273 5 - 2.031 1.984 -0.160
ENSG00000122033 E010 246.930390 0.0003883288 0.781275478 0.88545632 13 27439989 27440205 217 - 2.391 2.393 0.006
ENSG00000122033 E011 144.165250 0.0017507795 0.593897509 0.76628924 13 27440206 27440275 70 - 2.163 2.154 -0.029
ENSG00000122033 E012 88.729206 0.0047205209 0.536962307 0.72698431 13 27440276 27440280 5 - 1.958 1.940 -0.062
ENSG00000122033 E013 184.725116 0.0148981030 0.626785556 0.78837029 13 27440281 27440449 169 - 2.273 2.257 -0.052
ENSG00000122033 E014 5.762583 0.0429638033 0.564133914 0.74623322 13 27440450 27440475 26 - 0.779 0.871 0.358
ENSG00000122033 E015 8.015307 0.0103100333 0.027621850 0.12018205 13 27441017 27441077 61 - 1.055 0.792 -0.995
ENSG00000122033 E016 7.607916 0.0044260347 0.048394746 0.17591563 13 27441078 27441245 168 - 1.022 0.793 -0.869
ENSG00000122033 E017 86.221876 0.0308435852 0.821054638 0.90861910 13 27445088 27445137 50 - 1.941 1.928 -0.044
ENSG00000122033 E018 64.145767 0.0199263054 0.565023169 0.74681443 13 27445138 27445156 19 - 1.824 1.787 -0.127
ENSG00000122033 E019 4.752171 0.0207733037 0.531827750 0.72332544 13 27449852 27449918 67 - 0.716 0.817 0.406
ENSG00000122033 E020 3.604410 0.1402351914 0.911543450 0.95792725 13 27449919 27450041 123 - 0.644 0.695 0.213
ENSG00000122033 E021 5.339226 0.0048378668 0.002872834 0.02264543 13 27450064 27450141 78 - 0.579 0.981 1.615
ENSG00000122033 E022 8.254565 0.0036644207 0.108321100 0.29624630 13 27450142 27450199 58 - 0.871 1.058 0.697
ENSG00000122033 E023 58.621459 0.0143775607 0.415625092 0.64029286 13 27450509 27450591 83 - 1.791 1.741 -0.167