ENSG00000121988

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264159 ENSG00000121988 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB3 protein_coding protein_coding 5.237884 1.349968 6.605573 0.3214841 0.4984046 2.282293 0.43200240 0.04575039 0.59777558 0.04575039 0.1080090 3.4464848 0.07410000 0.02443333 0.09410000 0.06966667 4.613220e-01 5.578491e-07 FALSE TRUE
ENST00000401392 ENSG00000121988 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB3 protein_coding protein_coding 5.237884 1.349968 6.605573 0.3214841 0.4984046 2.282293 0.08480309 0.13487597 0.09886973 0.06846092 0.0331405 -0.4122154 0.03184583 0.13186667 0.01453333 -0.11733333 3.466667e-01 5.578491e-07 FALSE TRUE
ENST00000403017 ENSG00000121988 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB3 protein_coding nonsense_mediated_decay 5.237884 1.349968 6.605573 0.3214841 0.4984046 2.282293 0.66805700 0.09126138 0.81735693 0.09126138 0.1573576 3.0304258 0.10969583 0.04873333 0.12146667 0.07273333 5.780591e-01 5.578491e-07 FALSE TRUE
MSTRG.19282.14 ENSG00000121988 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB3 protein_coding   5.237884 1.349968 6.605573 0.3214841 0.4984046 2.282293 1.80197604 0.37840530 2.18030264 0.20735378 0.4554846 2.4954954 0.36457917 0.22643333 0.32300000 0.09656667 8.416472e-01 5.578491e-07 FALSE TRUE
MSTRG.19282.16 ENSG00000121988 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB3 protein_coding   5.237884 1.349968 6.605573 0.3214841 0.4984046 2.282293 0.29352621 0.33489633 0.00000000 0.08992740 0.0000000 -5.1080909 0.08437083 0.27566667 0.00000000 -0.27566667 5.578491e-07 5.578491e-07 FALSE TRUE
MSTRG.19282.4 ENSG00000121988 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB3 protein_coding   5.237884 1.349968 6.605573 0.3214841 0.4984046 2.282293 1.14876388 0.35317419 2.39943731 0.10138478 0.2083847 2.7299627 0.18700833 0.28460000 0.36776667 0.08316667 7.995262e-01 5.578491e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000121988 E001 0.0000000       2 135136916 135136916 1 -      
ENSG00000121988 E002 0.1779838 0.035838179 1.000000000   2 135136917 135137347 431 - 0.059 0.000 -8.965
ENSG00000121988 E003 0.0000000       2 135152861 135152994 134 -      
ENSG00000121988 E004 0.1426347 0.032435881 1.000000000   2 135162415 135162627 213 - 0.059 0.000 -9.792
ENSG00000121988 E005 0.3337900 0.035723612 0.244091039   2 135165143 135165154 12 - 0.059 0.234 2.286
ENSG00000121988 E006 1.8975190 0.152023621 0.540196390 0.72913656 2 135192759 135192788 30 - 0.397 0.236 -1.052
ENSG00000121988 E007 1.8727686 0.215535728 0.156339671 0.37138331 2 135192789 135192824 36 - 0.424 0.000 -13.180
ENSG00000121988 E008 0.8380019 0.029081118 0.404925301   2 135196969 135196973 5 - 0.239 0.000 -12.024
ENSG00000121988 E009 23.8941526 0.018045730 0.215513193 0.44805711 2 135196974 135199662 2689 - 1.257 1.375 0.413
ENSG00000121988 E010 24.5041502 0.001832935 0.343178618 0.58085038 2 135199663 135200353 691 - 1.272 1.350 0.274
ENSG00000121988 E011 10.9902400 0.003224073 0.124479763 0.32288382 2 135200354 135200407 54 - 0.996 0.777 -0.838
ENSG00000121988 E012 9.4102641 0.003460109 0.024991121 0.11219380 2 135200408 135200440 33 - 0.949 0.586 -1.470
ENSG00000121988 E013 0.3206185 0.027442404 1.000000000   2 135202438 135202831 394 - 0.111 0.000 -10.761
ENSG00000121988 E014 18.5878258 0.002491636 0.697129259 0.83367544 2 135202832 135202963 132 - 1.185 1.141 -0.159
ENSG00000121988 E015 39.1832462 0.002187353 0.318435643 0.55832319 2 135207434 135207836 403 - 1.472 1.538 0.224
ENSG00000121988 E016 22.5116116 0.001968566 0.367954627 0.60238553 2 135208868 135208978 111 - 1.243 1.321 0.271
ENSG00000121988 E017 18.7936825 0.007806621 0.764096781 0.87511515 2 135217465 135217607 143 - 1.174 1.203 0.102
ENSG00000121988 E018 12.6201190 0.003593469 0.854009315 0.92709703 2 135219077 135219178 102 - 1.033 1.010 -0.085
ENSG00000121988 E019 8.7925402 0.004259922 0.136420603 0.34201634 2 135224426 135224449 24 - 0.854 1.040 0.697
ENSG00000121988 E020 11.8474485 0.003504398 0.237541119 0.47375914 2 135224450 135224517 68 - 0.983 1.117 0.487
ENSG00000121988 E021 5.8781959 0.005340959 0.844545991 0.92190110 2 135227812 135227817 6 - 0.754 0.721 -0.132
ENSG00000121988 E022 22.8023571 0.012365199 0.800841961 0.89676709 2 135227818 135228015 198 - 1.274 1.253 -0.074
ENSG00000121988 E023 0.0000000       2 135228016 135228312 297 -      
ENSG00000121988 E024 33.6962481 0.001355743 0.488067863 0.69271267 2 135230513 135230927 415 - 1.420 1.469 0.170
ENSG00000121988 E025 0.0000000       2 135230928 135230948 21 -      
ENSG00000121988 E026 0.6482515 0.031284048 0.677571307   2 135238764 135238861 98 - 0.158 0.233 0.693
ENSG00000121988 E027 17.7966673 0.060805027 0.884507126 0.94367631 2 135265534 135265686 153 - 1.160 1.177 0.058
ENSG00000121988 E028 16.3709403 0.010095016 0.730632837 0.85456879 2 135268962 135269066 105 - 1.134 1.092 -0.149
ENSG00000121988 E029 9.6753970 0.003381012 0.054763931 0.19080805 2 135269067 135269141 75 - 0.956 0.659 -1.175
ENSG00000121988 E030 0.0000000       2 135271301 135271395 95 -      
ENSG00000121988 E031 11.7480053 0.003387472 0.003331994 0.02538351 2 135271768 135271887 120 - 1.045 0.585 -1.824
ENSG00000121988 E032 11.1490350 0.015326825 0.001902598 0.01642294 2 135275636 135275755 120 - 1.038 0.496 -2.214
ENSG00000121988 E033 11.6029719 0.030807449 0.052651957 0.18586334 2 135313489 135313605 117 - 1.038 0.719 -1.229
ENSG00000121988 E034 20.2521958 0.023977511 0.043907751 0.16485297 2 135315359 135315530 172 - 1.251 0.978 -0.982
ENSG00000121988 E035 0.0000000       2 135345125 135345135 11 -      
ENSG00000121988 E036 0.0000000       2 135345136 135345182 47 -      
ENSG00000121988 E037 4.4329170 0.046233599 0.137267229 0.34333588 2 135345183 135345296 114 - 0.576 0.830 1.057
ENSG00000121988 E038 8.1104535 0.041868095 0.112631123 0.30355112 2 135345297 135345461 165 - 0.803 1.042 0.903
ENSG00000121988 E039 18.3637112 0.002069413 0.569704635 0.75003916 2 135345550 135345635 86 - 1.168 1.222 0.190
ENSG00000121988 E040 34.5852215 0.001184936 0.017858541 0.08855899 2 135349984 135350215 232 - 1.402 1.564 0.554
ENSG00000121988 E041 0.0000000       2 135353321 135353449 129 -      
ENSG00000121988 E042 34.0429679 0.001418827 0.069248430 0.22328367 2 135353450 135353628 179 - 1.402 1.529 0.435
ENSG00000121988 E043 16.0244623 0.003243731 0.386538223 0.61773036 2 135390802 135390820 19 - 1.141 1.040 -0.367
ENSG00000121988 E044 33.2707654 0.001443297 0.241915883 0.47869871 2 135504329 135504496 168 - 1.434 1.336 -0.340
ENSG00000121988 E045 2.3364518 0.019175287 0.712294012 0.84323023 2 135530498 135530525 28 - 0.462 0.384 -0.415
ENSG00000121988 E046 4.1154191 0.056974749 0.531097496 0.72286192 2 135530526 135530641 116 - 0.607 0.718 0.473
ENSG00000121988 E047 1.2567121 0.014599095 0.168497438   2 135530642 135530731 90 - 0.238 0.497 1.550
ENSG00000121988 E048 8.1628342 0.003748860 0.306525279 0.54717601 2 135531127 135531159 33 - 0.879 0.722 -0.622
ENSG00000121988 E049 9.0645199 0.003569848 0.086463592 0.25735705 2 135531160 135531218 59 - 0.927 0.659 -1.066