ENSG00000121892

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303538 ENSG00000121892 HEK293_OSMI2_6hA HEK293_TMG_6hB PDS5A protein_coding protein_coding 16.65847 4.800465 29.35041 1.014625 1.477488 2.609624 8.309208 4.015349 11.01530 0.9750846 2.4800469 1.453632 0.6669333 0.82296667 0.3686000 -0.4543667 0.004199077 0.004199077 FALSE TRUE
MSTRG.24762.2 ENSG00000121892 HEK293_OSMI2_6hA HEK293_TMG_6hB PDS5A protein_coding   16.65847 4.800465 29.35041 1.014625 1.477488 2.609624 7.278691 0.413817 17.00111 0.2594745 0.9877308 5.326892 0.2600542 0.09266667 0.5857667 0.4931000 0.096091732 0.004199077 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000121892 E001 364.6301429 1.7567475202 3.174415e-01 0.5574074123 4 39822863 39825020 2158 - 2.304 2.795 1.636
ENSG00000121892 E002 97.0019413 1.3508714460 3.998590e-01 0.6281183547 4 39825021 39825178 158 - 1.789 2.113 1.091
ENSG00000121892 E003 162.2192608 1.5293885054 4.309905e-01 0.6519118338 4 39825179 39825488 310 - 2.013 2.324 1.041
ENSG00000121892 E004 3.0296398 0.0077542097 1.674537e-01 0.3871944600 4 39837012 39837855 844 - 0.451 0.736 1.286
ENSG00000121892 E005 182.6147873 0.0082303533 7.139955e-02 0.2275895155 4 39837856 39838208 353 - 2.102 2.269 0.557
ENSG00000121892 E006 125.6652608 0.0003920664 2.710379e-01 0.5110128582 4 39841948 39842056 109 - 1.954 2.067 0.380
ENSG00000121892 E007 140.6529025 0.0009333547 4.011625e-01 0.6292637916 4 39844656 39844801 146 - 2.007 2.109 0.342
ENSG00000121892 E008 90.6573336 0.0030740404 5.859169e-01 0.7609035280 4 39845818 39845880 63 - 1.819 1.916 0.324
ENSG00000121892 E009 2.5293019 0.0915009035 2.635482e-02 0.1163527191 4 39845881 39848561 2681 - 0.328 0.797 2.225
ENSG00000121892 E010 112.3335369 0.0015484355 7.733672e-01 0.8806945574 4 39848851 39848970 120 - 1.918 1.974 0.188
ENSG00000121892 E011 148.0903771 0.0027664489 9.178434e-02 0.2669937010 4 39849520 39849652 133 - 2.044 2.036 -0.027
ENSG00000121892 E012 126.8451424 0.0066362337 1.320989e-02 0.0712896575 4 39862219 39862333 115 - 1.987 1.907 -0.269
ENSG00000121892 E013 113.8519589 0.0046931337 4.763338e-02 0.1741270028 4 39862869 39862985 117 - 1.937 1.900 -0.124
ENSG00000121892 E014 90.9009972 0.0013175971 5.741002e-01 0.7530988442 4 39862986 39863073 88 - 1.830 1.871 0.141
ENSG00000121892 E015 106.6380856 0.0045070537 5.866150e-01 0.7613469437 4 39863336 39863459 124 - 1.894 1.936 0.142
ENSG00000121892 E016 140.1374973 0.0051323182 2.717825e-01 0.5116480257 4 39866861 39866997 137 - 2.016 2.030 0.047
ENSG00000121892 E017 0.9091303 0.0396940197 3.806259e-01   4 39866998 39867015 18 - 0.193 0.395 1.404
ENSG00000121892 E018 0.3040503 0.0244411696 1.000000e+00   4 39868670 39868735 66 - 0.107 0.000 -9.204
ENSG00000121892 E019 107.9951470 0.0073142249 6.297996e-01 0.7903524768 4 39869394 39869462 69 - 1.900 1.945 0.151
ENSG00000121892 E020 0.0000000       4 39872792 39872985 194 -      
ENSG00000121892 E021 138.1233451 0.0079887824 3.802934e-01 0.6124219276 4 39872986 39873144 159 - 2.009 2.035 0.089
ENSG00000121892 E022 123.5915714 0.0046036619 1.236491e-01 0.3214926362 4 39874289 39874412 124 - 1.968 1.965 -0.012
ENSG00000121892 E023 127.0863748 0.0053525935 4.124471e-03 0.0298627211 4 39876993 39877153 161 - 1.992 1.909 -0.278
ENSG00000121892 E024 118.9516989 0.0061924746 1.125265e-03 0.0108577174 4 39879728 39879833 106 - 1.967 1.847 -0.403
ENSG00000121892 E025 127.9083753 0.0067116719 5.053740e-03 0.0349119866 4 39890249 39890364 116 - 1.994 1.902 -0.308
ENSG00000121892 E026 9.4343608 0.0038858449 5.496193e-02 0.1912624597 4 39898014 39898388 375 - 0.839 1.133 1.096
ENSG00000121892 E027 132.9172822 0.0032861242 3.418906e-01 0.5796060992 4 39898389 39898528 140 - 1.993 2.021 0.094
ENSG00000121892 E028 84.2343150 0.0043272235 5.596666e-02 0.1935767927 4 39898777 39898825 49 - 1.809 1.768 -0.137
ENSG00000121892 E029 71.8224626 0.0060760544 1.604828e-01 0.3775007286 4 39900426 39900454 29 - 1.736 1.716 -0.068
ENSG00000121892 E030 90.5759651 0.0032388547 4.480368e-02 0.1671432652 4 39900455 39900507 53 - 1.838 1.796 -0.142
ENSG00000121892 E031 112.1924769 0.0013492550 5.497563e-01 0.7361164652 4 39902347 39902460 114 - 1.918 1.961 0.146
ENSG00000121892 E032 55.5800417 0.0006701488 4.243756e-01 0.6468553809 4 39904040 39904041 2 - 1.624 1.644 0.066
ENSG00000121892 E033 137.5616835 0.0002991182 1.729690e-03 0.0152284269 4 39904042 39904191 150 - 2.023 1.965 -0.196
ENSG00000121892 E034 145.5257691 0.0011301707 4.479591e-05 0.0007575559 4 39908395 39908540 146 - 2.051 1.943 -0.361
ENSG00000121892 E035 0.1779838 0.0489253717 1.000000e+00   4 39908541 39908884 344 - 0.057 0.000 -8.208
ENSG00000121892 E036 0.1723744 0.0810692040 9.090065e-02   4 39910065 39910243 179 - 0.000 0.241 12.975
ENSG00000121892 E037 121.8624868 0.0053314427 7.730991e-03 0.0480572469 4 39910244 39910338 95 - 1.970 1.886 -0.282
ENSG00000121892 E038 120.1854034 0.0103077466 1.589033e-01 0.3751122137 4 39913611 39913726 116 - 1.956 1.931 -0.085
ENSG00000121892 E039 108.0192330 0.0075272849 1.090944e-01 0.2975894959 4 39917048 39917188 141 - 1.910 1.884 -0.089
ENSG00000121892 E040 98.3543780 0.0060574312 4.931471e-03 0.0342652619 4 39920319 39920399 81 - 1.881 1.780 -0.341
ENSG00000121892 E041 105.2263955 0.0048400390 5.270332e-03 0.0360329979 4 39922622 39922748 127 - 1.910 1.820 -0.302
ENSG00000121892 E042 76.7107118 0.0168254684 1.289748e-01 0.3301810576 4 39925836 39925933 98 - 1.769 1.709 -0.202
ENSG00000121892 E043 56.9067254 0.0041753921 2.101631e-01 0.4420371711 4 39926775 39926861 87 - 1.636 1.621 -0.052
ENSG00000121892 E044 136.9977327 0.0035402125 1.648141e-03 0.0146540442 4 39927961 39928164 204 - 2.023 1.935 -0.296
ENSG00000121892 E045 0.1426347 0.0322364694 1.000000e+00   4 39976113 39976439 327 - 0.057 0.000 -8.204
ENSG00000121892 E046 96.0789188 0.0005306497 1.034464e-01 0.2879648503 4 39976440 39976617 178 - 1.862 1.854 -0.028
ENSG00000121892 E047 0.9062837 0.2191384958 3.245020e-01   4 39977248 39977252 5 - 0.154 0.403 1.847
ENSG00000121892 E048 1.6076202 0.2497112550 4.553961e-01 0.6697966804 4 39977253 39977456 204 - 0.268 0.523 1.448
ENSG00000121892 E049 33.4507528 0.0079371693 2.122501e-01 0.4443961029 4 39977457 39977956 500 - 1.381 1.553 0.590