ENSG00000121749

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000468049 ENSG00000121749 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D15 protein_coding nonsense_mediated_decay 21.65845 3.742494 41.18136 0.5615205 1.708015 3.45642 1.491309 0.0000000 4.460988 0.0000000 0.9418332 8.804450 0.05175833 0.0000000 0.10700000 0.10700000 6.886962e-06 6.886962e-06 FALSE FALSE
ENST00000483828 ENSG00000121749 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D15 protein_coding retained_intron 21.65845 3.742494 41.18136 0.5615205 1.708015 3.45642 4.301392 0.7073818 8.518722 0.3639621 0.3397154 3.571517 0.17194583 0.1943667 0.20716667 0.01280000 9.332183e-01 6.886962e-06 FALSE FALSE
ENST00000485960 ENSG00000121749 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D15 protein_coding protein_coding 21.65845 3.742494 41.18136 0.5615205 1.708015 3.45642 3.137824 0.8676017 4.087550 0.3014331 0.1001370 2.223123 0.23361667 0.2310000 0.09943333 -0.13156667 3.518390e-01 6.886962e-06 FALSE TRUE
ENST00000491063 ENSG00000121749 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D15 protein_coding protein_coding 21.65845 3.742494 41.18136 0.5615205 1.708015 3.45642 8.306772 1.7235274 16.761762 0.3647540 1.4058916 3.274252 0.32253333 0.4529667 0.40563333 -0.04733333 8.771383e-01 6.886962e-06 FALSE TRUE
ENST00000548679 ENSG00000121749 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D15 protein_coding processed_transcript 21.65845 3.742494 41.18136 0.5615205 1.708015 3.45642 1.273657 0.1287145 2.671707 0.1287145 0.3150533 4.272961 0.06098750 0.0272000 0.06573333 0.03853333 5.157682e-01 6.886962e-06 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000121749 E001 0.0000000       12 71839707 71839717 11 +      
ENSG00000121749 E002 0.7429130 0.7325404043 0.5554628488   12 71839718 71839758 41 + 0.178 0.253 0.642
ENSG00000121749 E003 1.0823125 0.0432200920 1.0000000000   12 71839759 71839762 4 + 0.255 0.250 -0.035
ENSG00000121749 E004 20.9571514 0.0017077059 0.0480171030 0.175024865 12 71839763 71839777 15 + 1.235 1.014 -0.791
ENSG00000121749 E005 37.4225131 0.0012232298 0.2542864726 0.492754202 12 71839778 71839811 34 + 1.459 1.372 -0.301
ENSG00000121749 E006 2.4343011 0.0099373165 0.8796521919 0.941092094 12 71841101 71841231 131 + 0.437 0.408 -0.157
ENSG00000121749 E007 0.2027342 0.0403480524 0.0618278773   12 71854563 71854602 40 + 0.000 0.251 12.259
ENSG00000121749 E008 0.7664957 0.0193874923 0.1722432332   12 71854785 71854853 69 + 0.146 0.408 1.958
ENSG00000121749 E009 1.4944356 0.0130845006 0.5596766976 0.743032365 12 71861405 71861496 92 + 0.287 0.408 0.734
ENSG00000121749 E010 0.0000000       12 71868802 71868921 120 +      
ENSG00000121749 E011 73.6648573 0.0008113544 0.2621577055 0.501310783 12 71872070 71872168 99 + 1.738 1.678 -0.203
ENSG00000121749 E012 86.7907922 0.0004586536 0.0857268822 0.255896033 12 71872929 71873003 75 + 1.813 1.725 -0.296
ENSG00000121749 E013 118.5766457 0.0033393915 0.1648744538 0.383848903 12 71880469 71880607 139 + 1.943 1.874 -0.234
ENSG00000121749 E014 68.6373813 0.0007052877 0.1069181399 0.293880374 12 71884811 71884859 49 + 1.712 1.618 -0.320
ENSG00000121749 E015 102.4087532 0.0019632656 0.8121910294 0.903538179 12 71884860 71885021 162 + 1.868 1.883 0.053
ENSG00000121749 E016 78.2087724 0.0005943513 0.8346346682 0.916356504 12 71893222 71893324 103 + 1.757 1.750 -0.022
ENSG00000121749 E017 1.4027433 0.1440891179 0.5559801153 0.740500318 12 71894325 71894375 51 + 0.284 0.408 0.753
ENSG00000121749 E018 0.0000000       12 71894376 71894379 4 +      
ENSG00000121749 E019 141.4965574 0.0004880527 0.0227900801 0.105279359 12 71894686 71894883 198 + 2.023 1.930 -0.312
ENSG00000121749 E020 113.3335717 0.0003540262 0.0138660117 0.073821798 12 71895947 71896075 129 + 1.930 1.817 -0.380
ENSG00000121749 E021 0.1426347 0.0325123160 1.0000000000   12 71896388 71896676 289 + 0.054 0.000 -7.202
ENSG00000121749 E022 92.6558796 0.0004110282 0.5301701024 0.722190471 12 71896677 71896780 104 + 1.833 1.807 -0.090
ENSG00000121749 E023 0.1779838 0.0363138850 1.0000000000   12 71897217 71897286 70 + 0.055 0.000 -7.206
ENSG00000121749 E024 106.7327611 0.0004143879 0.8290192846 0.913262590 12 71897847 71897941 95 + 1.886 1.901 0.050
ENSG00000121749 E025 118.8009639 0.0006828763 0.8850081417 0.943904520 12 71907022 71907138 117 + 1.933 1.945 0.039
ENSG00000121749 E026 4.6295462 0.0057745819 0.0462407001 0.170638545 12 71907139 71907762 624 + 0.676 0.250 -2.263
ENSG00000121749 E027 3.5338019 0.0075241513 0.4325325767 0.653127460 12 71907863 71907989 127 + 0.565 0.408 -0.777
ENSG00000121749 E028 10.8129797 0.0437649060 0.0006659187 0.007147084 12 71913360 71913825 466 + 0.830 1.295 1.698
ENSG00000121749 E029 106.6373663 0.0037450306 0.9937213253 0.998501489 12 71913826 71913926 101 + 1.886 1.887 0.002
ENSG00000121749 E030 104.4876226 0.0009225016 0.9272304057 0.965664090 12 71917698 71917797 100 + 1.879 1.879 0.000
ENSG00000121749 E031 98.5842719 0.0006328264 0.1246763471 0.323229256 12 71918451 71918548 98 + 1.845 1.922 0.259
ENSG00000121749 E032 82.5820260 0.0011138828 0.0281195450 0.121602465 12 71920731 71920847 117 + 1.762 1.879 0.395
ENSG00000121749 E033 74.8409383 0.0005861288 0.0011939721 0.011385324 12 71921368 71921454 87 + 1.709 1.879 0.576
ENSG00000121749 E034 190.2567967 0.0029424271 0.0070872062 0.045018818 12 71922983 71927248 4266 + 2.121 2.228 0.359