ENSG00000121741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382871 ENSG00000121741 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM2 protein_coding protein_coding 9.314604 2.738973 16.61545 0.3798615 0.8912375 2.596429 1.24281556 0.00000000 1.82502074 0.00000000 0.11209959 7.51965256 0.10357083 0.00000000 0.110900000 0.11090000 1.375378e-06 1.375378e-06 FALSE TRUE
ENST00000382881 ENSG00000121741 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM2 protein_coding retained_intron 9.314604 2.738973 16.61545 0.3798615 0.8912375 2.596429 1.76850160 0.28728115 3.71865973 0.15355634 0.60914982 3.64875727 0.12822500 0.10756667 0.226633333 0.11906667 6.548063e-01 1.375378e-06 FALSE TRUE
ENST00000494061 ENSG00000121741 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM2 protein_coding retained_intron 9.314604 2.738973 16.61545 0.3798615 0.8912375 2.596429 3.07839937 1.27191703 5.55397943 0.30855092 0.39331097 2.11781420 0.38209167 0.45336667 0.333833333 -0.11953333 6.348039e-01 1.375378e-06   FALSE
ENST00000610343 ENSG00000121741 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM2 protein_coding protein_coding 9.314604 2.738973 16.61545 0.3798615 0.8912375 2.596429 0.96609235 0.51533037 2.39334386 0.08806273 0.33942153 2.19374617 0.10950000 0.19140000 0.143266667 -0.04813333 7.211745e-01 1.375378e-06 FALSE TRUE
ENST00000620447 ENSG00000121741 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM2 protein_coding protein_coding 9.314604 2.738973 16.61545 0.3798615 0.8912375 2.596429 1.05595098 0.06721711 1.65347319 0.06721711 0.85242512 4.42913415 0.07213333 0.03303333 0.095600000 0.06256667 7.969545e-01 1.375378e-06 FALSE TRUE
MSTRG.8393.10 ENSG00000121741 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM2 protein_coding   9.314604 2.738973 16.61545 0.3798615 0.8912375 2.596429 0.35194576 0.22584404 0.21521604 0.13347811 0.14539759 -0.06652355 0.06840833 0.08143333 0.012133333 -0.06930000 5.950433e-01 1.375378e-06 FALSE TRUE
MSTRG.8393.9 ENSG00000121741 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM2 protein_coding   9.314604 2.738973 16.61545 0.3798615 0.8912375 2.596429 0.09776494 0.21906541 0.02619983 0.21906541 0.02619983 -2.66170459 0.02060417 0.07706667 0.001433333 -0.07563333 8.222290e-01 1.375378e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000121741 E001 0.1779838 0.0367296207 1.000000e+00   13 19958677 19958707 31 + 0.062 0.000 -8.714
ENSG00000121741 E002 0.3206185 0.0274424043 1.000000e+00   13 19958708 19958726 19 + 0.117 0.000 -11.021
ENSG00000121741 E003 0.9640683 0.0152222920 2.300052e-01   13 19958727 19958744 18 + 0.284 0.000 -12.538
ENSG00000121741 E004 2.0525875 0.0099776432 3.425304e-01 5.802398e-01 13 19958745 19958771 27 + 0.378 0.569 0.965
ENSG00000121741 E005 2.2305714 0.0099755872 4.249144e-01 6.472176e-01 13 19958772 19958782 11 + 0.405 0.569 0.812
ENSG00000121741 E006 7.6097349 0.0119658481 6.030566e-01 7.722862e-01 13 19958783 19958838 56 + 0.855 0.805 -0.195
ENSG00000121741 E007 7.2928729 0.0058108556 9.946080e-01 9.988960e-01 13 19958839 19958841 3 + 0.826 0.850 0.093
ENSG00000121741 E008 0.8156366 0.0168015740 2.966458e-01   13 19958842 19958904 63 + 0.165 0.372 1.551
ENSG00000121741 E009 0.6847684 0.0187830962 7.796469e-01   13 19958905 19958959 55 + 0.165 0.225 0.553
ENSG00000121741 E010 3.8864928 0.0064217569 5.910870e-01 7.644406e-01 13 19958960 19959135 176 + 0.594 0.703 0.471
ENSG00000121741 E011 0.1779838 0.0367296207 1.000000e+00   13 19959859 19959957 99 + 0.062 0.000 -10.051
ENSG00000121741 E012 20.2488749 0.0039493509 2.794331e-01 5.195268e-01 13 19959958 19960026 69 + 1.243 1.161 -0.288
ENSG00000121741 E013 0.3337900 0.0305131138 2.993873e-01   13 19965220 19965281 62 + 0.062 0.225 2.137
ENSG00000121741 E014 4.8289335 0.0057730805 9.486138e-01 9.765563e-01 13 19970025 19970071 47 + 0.672 0.704 0.135
ENSG00000121741 E015 108.8309379 0.0005421604 3.149492e-06 7.745927e-05 13 19993063 19993564 502 + 1.970 1.782 -0.634
ENSG00000121741 E016 32.5267019 0.0012196259 5.920497e-03 3.934556e-02 13 19993565 19993825 261 + 1.458 1.253 -0.712
ENSG00000121741 E017 49.1143221 0.0008491478 4.969221e-04 5.645809e-03 13 19993826 19993919 94 + 1.630 1.415 -0.737
ENSG00000121741 E018 70.0860387 0.0092864161 4.317503e-03 3.092805e-02 13 20002850 20003135 286 + 1.778 1.600 -0.602
ENSG00000121741 E019 52.2815292 0.0154725851 3.161133e-02 1.320947e-01 13 20005074 20005239 166 + 1.650 1.492 -0.539
ENSG00000121741 E020 67.8670854 0.0167409888 4.279886e-02 1.620275e-01 13 20006374 20006586 213 + 1.758 1.614 -0.485
ENSG00000121741 E021 36.9692947 0.0141065951 2.049382e-01 4.358357e-01 13 20019547 20019618 72 + 1.492 1.402 -0.311
ENSG00000121741 E022 1.7822211 0.3461450575 2.228417e-01 4.568174e-01 13 20019619 20019963 345 + 0.284 0.644 1.881
ENSG00000121741 E023 5.5964017 0.0883604219 3.539440e-01 5.907808e-01 13 20024394 20025306 913 + 0.688 0.887 0.793
ENSG00000121741 E024 2.3212887 0.0094160414 5.069539e-01 7.056399e-01 13 20025307 20025375 69 + 0.430 0.569 0.676
ENSG00000121741 E025 7.8105771 0.0087141780 1.756907e-02 8.753204e-02 13 20025376 20026518 1143 + 0.773 1.096 1.222
ENSG00000121741 E026 1.6070703 0.0119515408 1.402880e-01 3.479499e-01 13 20026519 20026611 93 + 0.284 0.569 1.553
ENSG00000121741 E027 51.8556195 0.0020237505 8.697255e-03 5.247056e-02 13 20026612 20026762 151 + 1.646 1.497 -0.510
ENSG00000121741 E028 47.7603714 0.0008050963 3.246148e-02 1.345908e-01 13 20027203 20027318 116 + 1.605 1.488 -0.399
ENSG00000121741 E029 0.6246688 0.0191946570 4.389674e-01   13 20027985 20028064 80 + 0.208 0.000 -11.981
ENSG00000121741 E030 44.8369881 0.0014953339 2.032060e-01 4.335797e-01 13 20031319 20031435 117 + 1.567 1.507 -0.205
ENSG00000121741 E031 0.1426347 0.0319434538 1.000000e+00   13 20031436 20031439 4 + 0.062 0.000 -10.041
ENSG00000121741 E032 53.5598255 0.0098633273 1.137964e-01 3.054675e-01 13 20034254 20034404 151 + 1.647 1.551 -0.328
ENSG00000121741 E033 62.3341141 0.0007813466 4.311422e-02 1.628729e-01 13 20036737 20036909 173 + 1.716 1.626 -0.308
ENSG00000121741 E034 0.5008152 0.0366991506 6.450716e-01   13 20036910 20036913 4 + 0.165 0.000 -11.609
ENSG00000121741 E035 25.0261946 0.0091222310 3.759666e-01 6.089730e-01 13 20051433 20051440 8 + 1.330 1.268 -0.216
ENSG00000121741 E036 68.6786382 0.0007812945 8.429047e-01 9.210963e-01 13 20051441 20051598 158 + 1.740 1.757 0.056
ENSG00000121741 E037 43.3356316 0.0124349103 3.909699e-01 6.211209e-01 13 20052277 20052311 35 + 1.527 1.618 0.314
ENSG00000121741 E038 68.5554527 0.0091338697 8.107161e-01 9.026910e-01 13 20058575 20058704 130 + 1.730 1.771 0.139
ENSG00000121741 E039 66.6288037 0.0011757985 2.094206e-01 4.411913e-01 13 20059447 20059562 116 + 1.708 1.801 0.315
ENSG00000121741 E040 78.1745857 0.0007257394 5.879286e-01 7.622975e-01 13 20061053 20061224 172 + 1.783 1.837 0.180
ENSG00000121741 E041 53.1896410 0.0007845352 1.176696e-02 6.550946e-02 13 20062846 20062971 126 + 1.594 1.762 0.568
ENSG00000121741 E042 47.0570943 0.0008330492 1.864760e-02 9.122519e-02 13 20064451 20064545 95 + 1.542 1.708 0.565
ENSG00000121741 E043 0.1779838 0.0367296207 1.000000e+00   13 20066578 20066850 273 + 0.062 0.000 -10.051
ENSG00000121741 E044 54.0778808 0.0009321314 7.880274e-01 8.893975e-01 13 20066851 20066978 128 + 1.629 1.672 0.146
ENSG00000121741 E045 32.3148180 0.0167979653 4.035027e-01 6.311185e-01 13 20066979 20067019 41 + 1.429 1.377 -0.179
ENSG00000121741 E046 71.8507925 0.0007684081 4.141171e-01 6.390714e-01 13 20067239 20067390 152 + 1.762 1.746 -0.052
ENSG00000121741 E047 0.9335208 0.0160162376 8.816090e-01   13 20068089 20068349 261 + 0.248 0.224 -0.188
ENSG00000121741 E048 67.8872241 0.0005735329 2.641070e-01 5.033550e-01 13 20082016 20082130 115 + 1.717 1.801 0.284
ENSG00000121741 E049 94.6701855 0.0044857720 2.515577e-02 1.126917e-01 13 20082781 20083009 229 + 1.846 1.985 0.468
ENSG00000121741 E050 39.8414367 0.0037812190 7.047011e-03 4.484877e-02 13 20083010 20083032 23 + 1.459 1.667 0.708
ENSG00000121741 E051 0.1426347 0.0319434538 1.000000e+00   13 20083631 20083655 25 + 0.062 0.000 -10.041
ENSG00000121741 E052 60.1173067 0.0464157793 4.361078e-02 1.641644e-01 13 20083656 20083776 121 + 1.628 1.861 0.790
ENSG00000121741 E053 176.8450274 0.0827724242 5.351427e-02 1.879035e-01 13 20085822 20091829 6008 + 2.087 2.330 0.809