ENSG00000121274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000561678 ENSG00000121274 HEK293_OSMI2_6hA HEK293_TMG_6hB TENT4B protein_coding protein_coding 6.119389 1.368996 10.66543 0.2727815 0.3897398 2.952604 0.4465863 0.07131872 0.4616271 0.02779764 0.1114965 2.535987 0.06184167 0.0484000 0.04266667 -0.005733333 0.9915581207 0.0002081829 FALSE TRUE
ENST00000562717 ENSG00000121274 HEK293_OSMI2_6hA HEK293_TMG_6hB TENT4B protein_coding processed_transcript 6.119389 1.368996 10.66543 0.2727815 0.3897398 2.952604 1.6818399 0.13653614 3.8955697 0.07417023 0.4732197 4.736205 0.20084583 0.1353333 0.36793333 0.232600000 0.4059015466 0.0002081829 TRUE TRUE
MSTRG.12617.2 ENSG00000121274 HEK293_OSMI2_6hA HEK293_TMG_6hB TENT4B protein_coding   6.119389 1.368996 10.66543 0.2727815 0.3897398 2.952604 1.7376471 0.78642888 2.2556421 0.28877903 0.9647781 1.508303 0.36753333 0.5233333 0.20566667 -0.317666667 0.4151511367 0.0002081829 FALSE TRUE
MSTRG.12617.5 ENSG00000121274 HEK293_OSMI2_6hA HEK293_TMG_6hB TENT4B protein_coding   6.119389 1.368996 10.66543 0.2727815 0.3897398 2.952604 0.4397616 0.26725632 1.1275563 0.13362913 0.3505585 2.036646 0.08118750 0.1634000 0.10353333 -0.059866667 0.9534884018 0.0002081829 FALSE TRUE
MSTRG.12617.6 ENSG00000121274 HEK293_OSMI2_6hA HEK293_TMG_6hB TENT4B protein_coding   6.119389 1.368996 10.66543 0.2727815 0.3897398 2.952604 0.2650643 0.10745614 0.0000000 0.10745614 0.0000000 -3.554050 0.11986667 0.1295000 0.00000000 -0.129500000 0.6596753474 0.0002081829 FALSE TRUE
MSTRG.12617.7 ENSG00000121274 HEK293_OSMI2_6hA HEK293_TMG_6hB TENT4B protein_coding   6.119389 1.368996 10.66543 0.2727815 0.3897398 2.952604 1.4897457 0.00000000 2.9250365 0.00000000 0.7372829 8.197235 0.13796250 0.0000000 0.28016667 0.280166667 0.0002081829 0.0002081829 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000121274 E001 0.0000000       16 50152911 50152918 8 +      
ENSG00000121274 E002 0.0000000       16 50152919 50152919 1 +      
ENSG00000121274 E003 0.0000000       16 50152920 50152928 9 +      
ENSG00000121274 E004 0.5233527 0.022412106 0.53373263   16 50152929 50152939 11 + 0.104 0.248 1.510
ENSG00000121274 E005 1.5851529 0.011819223 0.93522352 0.96977253 16 50152940 50153032 93 + 0.318 0.405 0.508
ENSG00000121274 E006 5.0987322 0.007227748 0.96310889 0.98350826 16 50153306 50153648 343 + 0.642 0.750 0.451
ENSG00000121274 E007 6.6543330 0.005551640 0.47232808 0.68180543 16 50153649 50153674 26 + 0.758 0.750 -0.034
ENSG00000121274 E008 7.4865377 0.004900167 0.77864867 0.88393631 16 50153675 50153743 69 + 0.788 0.855 0.262
ENSG00000121274 E009 5.1013210 0.014558304 0.65911119 0.80946080 16 50153744 50153746 3 + 0.628 0.806 0.733
ENSG00000121274 E010 29.4839892 0.026796149 0.70018596 0.83577265 16 50153747 50154160 414 + 1.314 1.500 0.643
ENSG00000121274 E011 31.2716447 0.100529916 0.38840565 0.61919293 16 50154161 50154259 99 + 1.375 1.357 -0.060
ENSG00000121274 E012 39.9789971 0.048042033 0.23735055 0.47349358 16 50211323 50211446 124 + 1.477 1.455 -0.075
ENSG00000121274 E013 21.3125307 0.031016932 0.07499000 0.23479896 16 50214221 50214225 5 + 1.227 1.124 -0.365
ENSG00000121274 E014 27.4435271 0.034239186 0.04544725 0.16867600 16 50214226 50214267 42 + 1.332 1.215 -0.412
ENSG00000121274 E015 41.3953835 0.040366025 0.05944808 0.20157603 16 50216075 50216195 121 + 1.500 1.419 -0.278
ENSG00000121274 E016 42.1150576 0.018845767 0.06535691 0.21470366 16 50217556 50217663 108 + 1.502 1.459 -0.147
ENSG00000121274 E017 57.7769562 0.032594836 0.28874712 0.52941959 16 50222306 50222434 129 + 1.623 1.651 0.095
ENSG00000121274 E018 92.5314517 0.038505966 0.18304489 0.40786774 16 50223174 50223387 214 + 1.827 1.838 0.037
ENSG00000121274 E019 1.8801430 0.320904754 0.58687255 0.76152479 16 50223388 50223400 13 + 0.327 0.522 1.052
ENSG00000121274 E020 78.3704989 0.024191093 0.07635303 0.23744092 16 50224657 50224783 127 + 1.760 1.755 -0.016
ENSG00000121274 E021 70.8336570 0.023348756 0.01442449 0.07598047 16 50224891 50224994 104 + 1.726 1.652 -0.251
ENSG00000121274 E022 0.2617363 0.138807672 0.02597201   16 50224995 50225011 17 + 0.000 0.400 12.433
ENSG00000121274 E023 42.0858536 0.001627679 0.02051161 0.09771769 16 50225098 50225238 141 + 1.504 1.458 -0.160
ENSG00000121274 E024 47.0129865 0.004622242 0.06061375 0.20421178 16 50225239 50225285 47 + 1.548 1.533 -0.050
ENSG00000121274 E025 76.6791825 0.023839886 0.75193157 0.86793729 16 50227839 50228003 165 + 1.741 1.808 0.228
ENSG00000121274 E026 45.8451363 0.461893238 0.51269181 0.70996748 16 50229152 50229197 46 + 1.510 1.634 0.425
ENSG00000121274 E027 295.9821011 0.961617631 0.24343194 0.48047961 16 50229198 50234925 5728 + 2.244 2.631 1.290
ENSG00000121274 E028 1.3636376 0.012656375 0.53500288   16 50234926 50235310 385 + 0.318 0.248 -0.492