ENSG00000121067

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000504102 ENSG00000121067 HEK293_OSMI2_6hA HEK293_TMG_6hB SPOP protein_coding protein_coding 26.72441 15.45906 36.42892 3.81722 1.775244 1.236095 13.5361098 9.510961 16.419979 2.535189 0.6532961 0.7871516 0.54276250 0.6072000 0.4513 -0.1559000 0.1330240277 6.85872e-05 FALSE TRUE
ENST00000659760 ENSG00000121067 HEK293_OSMI2_6hA HEK293_TMG_6hB SPOP protein_coding nonsense_mediated_decay 26.72441 15.45906 36.42892 3.81722 1.775244 1.236095 0.8917924 0.000000 2.101242 0.000000 0.6710539 7.7219482 0.02499583 0.0000000 0.0592 0.0592000 0.0000685872 6.85872e-05 FALSE TRUE
MSTRG.14639.4 ENSG00000121067 HEK293_OSMI2_6hA HEK293_TMG_6hB SPOP protein_coding   26.72441 15.45906 36.42892 3.81722 1.775244 1.236095 6.4813404 3.375395 11.382685 1.268300 0.8402230 1.7507117 0.21421250 0.2106333 0.3121 0.1014667 0.4345831466 6.85872e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000121067 E001 0.1614157 0.0356646280 9.002032e-01   17 49598884 49598885 2 - 0.096 0.000 -9.627
ENSG00000121067 E002 142.8324668 0.0006605219 3.820239e-05 0.0006626807 17 49598886 49599496 611 - 2.091 2.220 0.433
ENSG00000121067 E003 104.8390535 0.0005056760 1.460172e-04 0.0020508454 17 49599497 49599526 30 - 1.955 2.090 0.452
ENSG00000121067 E004 93.7926139 0.0004646061 5.303773e-03 0.0362104201 17 49599527 49599546 20 - 1.922 2.026 0.349
ENSG00000121067 E005 117.0174548 0.0023966538 2.260171e-02 0.1045998222 17 49599547 49599623 77 - 2.022 2.110 0.295
ENSG00000121067 E006 355.6961964 0.0002329835 1.697612e-01 0.3901710494 17 49599624 49599989 366 - 2.531 2.556 0.085
ENSG00000121067 E007 77.1364719 0.0014746819 3.513641e-02 0.1419396290 17 49599990 49600005 16 - 1.849 1.939 0.304
ENSG00000121067 E008 137.2875212 0.0004331224 8.502986e-02 0.2546570765 17 49600006 49600088 83 - 2.108 2.161 0.177
ENSG00000121067 E009 94.2361863 0.0004922323 6.239463e-01 0.7865736778 17 49600089 49600092 4 - 1.973 1.953 -0.067
ENSG00000121067 E010 182.5151040 0.0002806786 3.651414e-01 0.6000695337 17 49600093 49600202 110 - 2.262 2.236 -0.085
ENSG00000121067 E011 160.9091569 0.0002658224 1.056956e-01 0.2918503877 17 49600203 49600278 76 - 2.214 2.167 -0.157
ENSG00000121067 E012 128.3132842 0.0004091866 4.087488e-01 0.6350711036 17 49600279 49600308 30 - 2.110 2.084 -0.089
ENSG00000121067 E013 259.8181140 0.0007892316 8.967810e-01 0.9501927099 17 49600309 49600522 214 - 2.404 2.406 0.007
ENSG00000121067 E014 17.9305135 0.0560339277 2.651038e-01 0.5044283060 17 49600523 49601631 1109 - 1.327 1.134 -0.685
ENSG00000121067 E015 3.9995052 0.0068287739 2.472905e-02 0.1113794474 17 49601681 49601864 184 - 0.791 0.430 -1.616
ENSG00000121067 E016 225.3874797 0.0030273147 9.664372e-01 0.9851041085 17 49601865 49602007 143 - 2.341 2.341 -0.001
ENSG00000121067 E017 4.9084978 0.3103905756 8.270967e-01 0.9121521514 17 49602008 49602398 391 - 0.795 0.694 -0.409
ENSG00000121067 E018 2.4458799 0.0087898314 4.611118e-02 0.1702778606 17 49607068 49607249 182 - 0.624 0.266 -1.921
ENSG00000121067 E019 219.8860634 0.0002153176 7.196089e-02 0.2287383354 17 49607250 49607372 123 - 2.350 2.305 -0.149
ENSG00000121067 E020 136.6613272 0.0005621831 7.483525e-01 0.8657232303 17 49607874 49607929 56 - 2.132 2.122 -0.033
ENSG00000121067 E021 135.6993874 0.0004025342 3.893251e-01 0.6199523981 17 49611280 49611337 58 - 2.116 2.144 0.094
ENSG00000121067 E022 127.6450506 0.0008745365 9.891611e-01 0.9963678009 17 49611338 49611380 43 - 2.101 2.102 0.004
ENSG00000121067 E023 145.1461066 0.0005534153 4.827162e-01 0.6888898856 17 49611381 49611457 77 - 2.148 2.169 0.071
ENSG00000121067 E024 0.0000000       17 49612779 49612941 163 -      
ENSG00000121067 E025 0.7920539 0.0801625006 4.712198e-01   17 49618504 49618563 60 - 0.296 0.154 -1.203
ENSG00000121067 E026 229.7998240 0.0024299965 3.421798e-01 0.5799054737 17 49618981 49619108 128 - 2.364 2.334 -0.102
ENSG00000121067 E027 208.7252176 0.0008203095 3.525463e-02 0.1422565091 17 49619234 49619318 85 - 2.333 2.274 -0.196
ENSG00000121067 E028 168.8147342 0.0007510403 1.118271e-02 0.0631279652 17 49619319 49619385 67 - 2.249 2.172 -0.256
ENSG00000121067 E029 1.1833707 0.0150676126 1.941226e-01   17 49620621 49620670 50 - 0.394 0.153 -1.806
ENSG00000121067 E030 152.9930428 0.0002765685 6.930514e-02 0.2233870914 17 49621946 49622024 79 - 2.196 2.142 -0.181
ENSG00000121067 E031 96.1223625 0.0017303383 3.933244e-02 0.1530592827 17 49622025 49622049 25 - 2.004 1.918 -0.290
ENSG00000121067 E032 74.1204555 0.0004995511 8.141525e-01 0.9047245674 17 49622050 49622067 18 - 1.862 1.872 0.035
ENSG00000121067 E033 0.3206185 0.0274424043 4.185435e-01   17 49622206 49622283 78 - 0.174 0.000 -10.619
ENSG00000121067 E034 0.1426347 0.0333396729 9.002829e-01   17 49622414 49622732 319 - 0.096 0.000 -9.618
ENSG00000121067 E035 149.4841097 0.0004397357 3.776419e-01 0.6103299586 17 49622733 49622876 144 - 2.175 2.147 -0.095
ENSG00000121067 E036 0.0000000       17 49636197 49636313 117 -      
ENSG00000121067 E037 5.3564026 0.0068719344 4.581055e-01 0.6718022704 17 49636759 49636809 51 - 0.824 0.719 -0.420
ENSG00000121067 E038 0.0000000       17 49646116 49646630 515 -      
ENSG00000121067 E039 0.3032425 0.0274424043 8.921780e-02   17 49646926 49647122 197 - 0.000 0.266 12.139
ENSG00000121067 E040 2.6998641 0.1465852725 6.560833e-01 0.8074238268 17 49668027 49668078 52 - 0.617 0.488 -0.597
ENSG00000121067 E041 12.4039852 0.0026453023 6.004204e-01 0.7705081043 17 49675895 49676016 122 - 1.099 1.149 0.177
ENSG00000121067 E042 87.0445506 0.0036100208 8.418977e-01 0.9205216956 17 49677933 49678163 231 - 1.942 1.927 -0.051