ENSG00000120992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316963 ENSG00000120992 HEK293_OSMI2_6hA HEK293_TMG_6hB LYPLA1 protein_coding protein_coding 51.00078 8.297634 86.27661 1.506788 2.617593 3.376627 32.359590 5.847873 56.117073 1.6765679 2.668993 3.260248 0.68627500 0.6713000 0.6531667 -0.01813333 9.716230e-01 4.205909e-09 FALSE TRUE
ENST00000520718 ENSG00000120992 HEK293_OSMI2_6hA HEK293_TMG_6hB LYPLA1 protein_coding processed_transcript 51.00078 8.297634 86.27661 1.506788 2.617593 3.376627 3.121513 1.093966 5.773045 0.2869172 0.772742 2.389134 0.08007500 0.1539667 0.0666000 -0.08736667 6.098441e-01 4.205909e-09   FALSE
MSTRG.31514.8 ENSG00000120992 HEK293_OSMI2_6hA HEK293_TMG_6hB LYPLA1 protein_coding   51.00078 8.297634 86.27661 1.506788 2.617593 3.376627 6.831329 0.000000 10.672639 0.0000000 2.714769 10.061052 0.07599167 0.0000000 0.1224333 0.12243333 4.205909e-09 4.205909e-09 FALSE TRUE
MSTRG.31514.9 ENSG00000120992 HEK293_OSMI2_6hA HEK293_TMG_6hB LYPLA1 protein_coding   51.00078 8.297634 86.27661 1.506788 2.617593 3.376627 3.171186 0.000000 5.096296 0.0000000 1.371638 8.996133 0.03879167 0.0000000 0.0582000 0.05820000 2.031398e-05 4.205909e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120992 E001 0.1426347 0.0332573944 6.209005e-01   8 54046367 54046367 1 - 0.043 0.000 -6.586
ENSG00000120992 E002 821.3483994 0.0059951669 3.051831e-03 2.372385e-02 8 54046368 54047406 1039 - 2.671 2.798 0.424
ENSG00000120992 E003 362.7536890 0.0014286651 2.291825e-03 1.899949e-02 8 54047407 54047791 385 - 2.317 2.445 0.427
ENSG00000120992 E004 306.5369929 0.0002237892 5.753428e-01 7.539036e-01 8 54047792 54047962 171 - 2.256 2.267 0.037
ENSG00000120992 E005 414.8755998 0.0015952132 2.350381e-02 1.075612e-01 8 54047963 54048118 156 - 2.394 2.344 -0.169
ENSG00000120992 E006 1.6278199 0.4037687615 1.027455e-02 5.929434e-02 8 54051011 54051011 1 - 0.153 0.844 3.826
ENSG00000120992 E007 279.1874593 0.0001920827 8.402948e-03 5.116946e-02 8 54051012 54051071 60 - 2.224 2.158 -0.220
ENSG00000120992 E008 265.9125003 0.0002804754 1.679321e-04 2.310894e-03 8 54051072 54051124 53 - 2.207 2.092 -0.385
ENSG00000120992 E009 181.6528986 0.0002891838 2.280984e-05 4.274593e-04 8 54051125 54051146 22 - 2.047 1.872 -0.588
ENSG00000120992 E010 165.7425701 0.0003731606 2.723151e-06 6.829916e-05 8 54051147 54051188 42 - 2.010 1.795 -0.723
ENSG00000120992 E011 1.1023109 0.0152323458 2.222490e-03   8 54052654 54052654 1 - 0.117 0.701 3.698
ENSG00000120992 E012 245.6173335 0.0001914671 1.264652e-01 3.261853e-01 8 54052655 54052741 87 - 2.164 2.136 -0.094
ENSG00000120992 E013 137.8707519 0.0004435335 5.695275e-01 7.499047e-01 8 54052742 54052756 15 - 1.911 1.911 0.000
ENSG00000120992 E014 9.1127395 0.1361736617 1.683158e-03 1.490110e-02 8 54052757 54052898 142 - 0.681 1.327 2.416
ENSG00000120992 E015 21.1000051 0.0891165886 2.195891e-02 1.024401e-01 8 54053198 54053668 471 - 1.069 1.464 1.391
ENSG00000120992 E016 18.2322634 0.1269892831 4.337928e-02 1.635322e-01 8 54054453 54055059 607 - 1.007 1.412 1.437
ENSG00000120992 E017 186.8767581 0.0003195357 4.493390e-01 6.652807e-01 8 54055060 54055101 42 - 2.044 2.040 -0.011
ENSG00000120992 E018 170.1662349 0.0008192913 1.700898e-01 3.905774e-01 8 54055102 54055133 32 - 2.007 1.971 -0.120
ENSG00000120992 E019 208.4633376 0.0002698170 5.947554e-01 7.668833e-01 8 54062254 54062324 71 - 2.091 2.100 0.028
ENSG00000120992 E020 156.8141847 0.0020985660 7.777291e-01 8.833176e-01 8 54063328 54063375 48 - 1.968 1.984 0.054
ENSG00000120992 E021 4.5122598 0.1784995647 2.762528e-02 1.201908e-01 8 54065333 54065450 118 - 0.473 1.001 2.195
ENSG00000120992 E022 141.0161610 0.0008093345 8.837797e-01 9.432374e-01 8 54065748 54065813 66 - 1.920 1.957 0.123
ENSG00000120992 E023 1.3872203 0.0129376985 2.851139e-01   8 54080253 54080329 77 - 0.237 0.478 1.473
ENSG00000120992 E024 0.1779838 0.0364583599 6.215390e-01   8 54100224 54100347 124 - 0.043 0.000 -6.576
ENSG00000120992 E025 1.1668026 0.0139208602 7.115717e-01   8 54100350 54100907 558 - 0.210 0.303 0.699
ENSG00000120992 E026 112.4830322 0.0003789718 4.471674e-01 6.636094e-01 8 54100908 54100939 32 - 1.820 1.889 0.234
ENSG00000120992 E027 4.1253139 0.0101532804 1.391562e-01 3.462704e-01 8 54101350 54101754 405 - 0.487 0.781 1.281
ENSG00000120992 E028 116.8297681 0.0004402889 7.876851e-02 2.423623e-01 8 54101755 54102017 263 - 1.829 1.947 0.397
ENSG00000120992 E029 0.1614157 0.0354796666 6.216440e-01   8 54102033 54102106 74 - 0.043 0.000 -6.574