ENSG00000120885

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405140 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding protein_coding 11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 0.15736000 0.1298110 0.1995136 0.1298110 0.1031166 0.5835661 0.01665833 0.005233333 0.06460000 0.05936667 5.038457e-01 4.356299e-05 FALSE TRUE
ENST00000519472 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding protein_coding 11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 2.76754719 7.5532036 0.5707077 2.1748783 0.5707077 -3.7031133 0.21795833 0.357566667 0.11713333 -0.24043333 3.057888e-01 4.356299e-05 FALSE FALSE
ENST00000521770 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding protein_coding 11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 0.55101691 0.3764212 0.4352500 0.3764212 0.4352500 0.2044415 0.06254583 0.015200000 0.10390000 0.08870000 9.044634e-01 4.356299e-05 FALSE TRUE
ENST00000522098 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding protein_coding 11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 2.89784617 5.3096400 0.4770612 0.6190137 0.2412390 -3.4491537 0.25285417 0.264466667 0.14606667 -0.11840000 7.500656e-01 4.356299e-05 FALSE FALSE
ENST00000522502 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding retained_intron 11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 0.21646472 0.0000000 0.4544533 0.0000000 0.4544533 5.5374616 0.02838333 0.000000000 0.09326667 0.09326667 6.665856e-01 4.356299e-05 FALSE FALSE
ENST00000523589 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding protein_coding 11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 0.07714278 0.0000000 0.6171422 0.0000000 0.6171422 5.9707207 0.01841250 0.000000000 0.14730000 0.14730000 7.148574e-01 4.356299e-05 FALSE FALSE
ENST00000560566 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding protein_coding 11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 0.91439018 1.7911074 0.0000000 0.2085035 0.0000000 -7.4927404 0.08054167 0.093633333 0.00000000 -0.09363333 4.356299e-05 4.356299e-05 FALSE TRUE
MSTRG.31310.3 ENSG00000120885 HEK293_OSMI2_6hA HEK293_TMG_6hB CLU protein_coding   11.11954 20.33748 3.88255 3.099407 0.6773261 -2.386062 3.42253753 4.9728399 1.1050612 0.9321020 0.5539540 -2.1598453 0.31150000 0.253133333 0.32286667 0.06973333 1.000000e+00 4.356299e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120885 E001 0.0000000       8 27596917 27597807 891 -      
ENSG00000120885 E002 0.8984613 0.0520801469 0.21911274   8 27597808 27597995 188 - 0.394 0.154 -1.788
ENSG00000120885 E003 17.1782432 0.0026333724 0.96214941 0.9831070 8 27597996 27598142 147 - 1.131 1.136 0.018
ENSG00000120885 E004 31.5496112 0.0014487131 0.22663579 0.4613371 8 27598143 27598250 108 - 1.463 1.369 -0.322
ENSG00000120885 E005 34.5663670 0.0015403957 0.28119333 0.5214789 8 27598460 27598536 77 - 1.495 1.416 -0.271
ENSG00000120885 E006 41.8090294 0.0051283143 0.72953039 0.8539628 8 27598537 27598635 99 - 1.525 1.503 -0.074
ENSG00000120885 E007 0.7569420 0.0440793135 0.20770553   8 27598636 27599779 1144 - 0.394 0.153 -1.809
ENSG00000120885 E008 60.2024815 0.0051598469 0.93948644 0.9719602 8 27599780 27600009 230 - 1.662 1.660 -0.007
ENSG00000120885 E009 0.0000000       8 27600010 27600015 6 -      
ENSG00000120885 E010 0.0000000       8 27604218 27604290 73 -      
ENSG00000120885 E011 27.7021038 0.0015999980 0.64584626 0.8007381 8 27604291 27604309 19 - 1.364 1.325 -0.134
ENSG00000120885 E012 39.9849697 0.0010399180 0.83389927 0.9159753 8 27604310 27604365 56 - 1.495 1.480 -0.050
ENSG00000120885 E013 32.1195558 0.0021702741 0.68458749 0.8256775 8 27604366 27604395 30 - 1.364 1.399 0.122
ENSG00000120885 E014 60.0144014 0.0008374415 0.12405045 0.3221491 8 27604924 27605069 146 - 1.570 1.665 0.325
ENSG00000120885 E015 36.5971782 0.0042872596 0.06821529 0.2210703 8 27605070 27605140 71 - 1.305 1.460 0.539
ENSG00000120885 E016 27.1307671 0.0037556924 0.09649651 0.2756350 8 27605141 27605171 31 - 1.176 1.338 0.567
ENSG00000120885 E017 47.2404235 0.0008285975 0.41836224 0.6423885 8 27605172 27605335 164 - 1.505 1.561 0.192
ENSG00000120885 E018 0.3336024 0.0274424043 1.00000000   8 27605336 27605339 4 - 0.000 0.108 9.553
ENSG00000120885 E019 17.5082528 0.0052835332 0.40380631 0.6313706 8 27606354 27606363 10 - 1.217 1.134 -0.296
ENSG00000120885 E020 19.0306950 0.0084816032 0.36842088 0.6027644 8 27606364 27606381 18 - 1.255 1.167 -0.310
ENSG00000120885 E021 46.5196800 0.0038402803 0.06957716 0.2239099 8 27606382 27606524 143 - 1.649 1.528 -0.412
ENSG00000120885 E022 0.5649788 0.0245359591 0.58990811   8 27608541 27608936 396 - 0.000 0.194 10.547
ENSG00000120885 E023 0.1308682 0.0326491905 1.00000000   8 27608937 27608937 1 - 0.000 0.057 8.550
ENSG00000120885 E024 54.2082541 0.0011274799 0.59805589 0.7689604 8 27608938 27609086 149 - 1.634 1.601 -0.111
ENSG00000120885 E025 23.4359834 0.0020766781 0.50125446 0.7016819 8 27610475 27610475 1 - 1.305 1.243 -0.216
ENSG00000120885 E026 39.3329566 0.0011408571 0.99177252 0.9976121 8 27610476 27610600 125 - 1.474 1.474 0.000
ENSG00000120885 E027 0.0000000       8 27610601 27611074 474 -      
ENSG00000120885 E028 0.0000000       8 27611075 27611109 35 -      
ENSG00000120885 E029 0.0000000       8 27611110 27611145 36 -      
ENSG00000120885 E030 0.0000000       8 27611146 27611431 286 -      
ENSG00000120885 E031 0.0000000       8 27611601 27611751 151 -      
ENSG00000120885 E032 0.2027342 0.0376791381 1.00000000   8 27611830 27611966 137 - 0.000 0.057 8.557
ENSG00000120885 E033 0.0000000       8 27613578 27613683 106 -      
ENSG00000120885 E034 0.0000000       8 27613684 27614172 489 -      
ENSG00000120885 E035 0.1723744 0.0358441617 1.00000000   8 27614173 27614370 198 - 0.000 0.057 8.555
ENSG00000120885 E036 18.7277825 0.0039505597 0.01102405 0.0624685 8 27614655 27614700 46 - 0.883 1.199 1.158