ENSG00000120837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000240055 ENSG00000120837 HEK293_OSMI2_6hA HEK293_TMG_6hB NFYB protein_coding protein_coding 15.2761 6.856188 24.51806 1.284366 0.7644192 1.836852 4.236258 1.022882 7.508080 0.1694095 0.2289347 2.863688 0.2773833 0.1530000 0.3064000 0.1534000 0.002132684 0.002132684 FALSE TRUE
ENST00000550189 ENSG00000120837 HEK293_OSMI2_6hA HEK293_TMG_6hB NFYB protein_coding retained_intron 15.2761 6.856188 24.51806 1.284366 0.7644192 1.836852 4.682116 1.714158 7.929055 0.8683712 0.5551747 2.203075 0.2574125 0.2109667 0.3228000 0.1118333 0.820598307 0.002132684 FALSE FALSE
ENST00000551727 ENSG00000120837 HEK293_OSMI2_6hA HEK293_TMG_6hB NFYB protein_coding protein_coding 15.2761 6.856188 24.51806 1.284366 0.7644192 1.836852 3.703163 2.759808 6.248615 0.2827722 0.1961533 1.176057 0.2757083 0.4217667 0.2555333 -0.1662333 0.172745673 0.002132684 FALSE TRUE
MSTRG.7886.4 ENSG00000120837 HEK293_OSMI2_6hA HEK293_TMG_6hB NFYB protein_coding   15.2761 6.856188 24.51806 1.284366 0.7644192 1.836852 2.321838 1.199238 2.447939 0.1384371 0.6147253 1.023351 0.1693667 0.1850000 0.0995000 -0.0855000 0.401608539 0.002132684 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120837 E001 0.761694 0.0666925131 8.321631e-01   12 104117086 104117117 32 - 0.241 0.193 -0.406
ENSG00000120837 E002 124.850799 0.0004091570 9.591536e-07 2.738967e-05 12 104117118 104119354 2237 - 2.082 1.895 -0.629
ENSG00000120837 E003 8.957499 0.0048257640 3.424301e-01 5.801653e-01 12 104119355 104119360 6 - 0.908 1.021 0.420
ENSG00000120837 E004 205.863764 0.0004408978 6.903067e-02 2.228410e-01 12 104119361 104119769 409 - 2.243 2.292 0.162
ENSG00000120837 E005 154.239600 0.0003019976 2.715840e-01 5.114515e-01 12 104120400 104120479 80 - 2.125 2.159 0.115
ENSG00000120837 E006 102.491003 0.0008623435 3.089924e-01 5.494891e-01 12 104121240 104121253 14 - 1.948 1.989 0.136
ENSG00000120837 E007 135.001583 0.0003682417 9.879057e-02 2.796878e-01 12 104121254 104121321 68 - 2.061 2.115 0.184
ENSG00000120837 E008 217.863017 0.0002790278 1.030056e-01 2.871660e-01 12 104123226 104123423 198 - 2.273 2.314 0.140
ENSG00000120837 E009 167.738757 0.0004013968 7.379717e-01 8.592644e-01 12 104126114 104126244 131 - 2.174 2.164 -0.033
ENSG00000120837 E010 150.085138 0.0006285146 2.753985e-02 1.199067e-01 12 104128424 104128517 94 - 2.137 2.062 -0.250
ENSG00000120837 E011 0.333790 0.0260543581 4.203212e-01   12 104128518 104128612 95 - 0.074 0.193 1.582
ENSG00000120837 E012 0.315009 0.0256556561 4.194666e-01   12 104131132 104131753 622 - 0.074 0.193 1.584
ENSG00000120837 E013 4.701679 0.0252548495 6.857609e-01 8.263475e-01 12 104131754 104131838 85 - 0.676 0.741 0.269
ENSG00000120837 E014 125.127510 0.0013599747 1.167941e-01 3.104643e-01 12 104135448 104135532 85 - 2.055 1.994 -0.205
ENSG00000120837 E015 10.048437 0.0033536733 8.242562e-04 8.475851e-03 12 104137345 104137375 31 - 0.866 1.221 1.301
ENSG00000120837 E016 22.375374 0.0016379546 3.050101e-11 2.409196e-09 12 104137376 104138140 765 - 1.124 1.615 1.707
ENSG00000120837 E017 60.321278 0.0007200768 2.231531e-08 9.689727e-07 12 104138141 104138241 101 - 1.792 1.461 -1.128