ENSG00000120805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261636 ENSG00000120805 HEK293_OSMI2_6hA HEK293_TMG_6hB ARL1 protein_coding protein_coding 40.07141 8.548745 66.3487 1.185078 0.9417046 2.954815 11.177274 3.0058649 15.70385 0.8668032 0.7004296 2.381393 0.30847917 0.3360667 0.2365333 -0.09953333 0.6689665743 0.0004929219 FALSE TRUE
ENST00000539055 ENSG00000120805 HEK293_OSMI2_6hA HEK293_TMG_6hB ARL1 protein_coding protein_coding 40.07141 8.548745 66.3487 1.185078 0.9417046 2.954815 8.256261 2.1142162 15.60373 0.3522337 0.9936437 2.877813 0.20990000 0.2493667 0.2355000 -0.01386667 0.9628208083 0.0004929219 FALSE TRUE
ENST00000549283 ENSG00000120805 HEK293_OSMI2_6hA HEK293_TMG_6hB ARL1 protein_coding processed_transcript 40.07141 8.548745 66.3487 1.185078 0.9417046 2.954815 8.657284 0.6321968 13.79772 0.6321968 3.0547027 4.426316 0.18144583 0.1016667 0.2090667 0.10740000 0.3563796999 0.0004929219 FALSE FALSE
ENST00000551671 ENSG00000120805 HEK293_OSMI2_6hA HEK293_TMG_6hB ARL1 protein_coding protein_coding 40.07141 8.548745 66.3487 1.185078 0.9417046 2.954815 8.452213 2.4618427 15.29393 0.7877772 2.5011903 2.630243 0.20796667 0.2707333 0.2299333 -0.04080000 0.9322038041 0.0004929219 FALSE TRUE
ENST00000551688 ENSG00000120805 HEK293_OSMI2_6hA HEK293_TMG_6hB ARL1 protein_coding protein_coding 40.07141 8.548745 66.3487 1.185078 0.9417046 2.954815 2.262311 0.0000000 4.15283 0.0000000 1.8867416 8.701421 0.04990833 0.0000000 0.0620000 0.06200000 0.0004929219 0.0004929219   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120805 E001 343.9552880 0.0059044583 0.07497060 0.23475988 12 101393116 101394917 1802 - 2.389 2.471 0.271
ENSG00000120805 E002 68.9146787 0.0007639116 0.06819274 0.22102252 12 101394918 101394943 26 - 1.729 1.624 -0.357
ENSG00000120805 E003 256.5841900 0.0013186473 0.45015989 0.66580232 12 101394944 101395487 544 - 2.282 2.261 -0.069
ENSG00000120805 E004 102.6453135 0.0004533357 0.90642065 0.95528075 12 101395488 101395506 19 - 1.884 1.883 -0.003
ENSG00000120805 E005 173.0536441 0.0002591063 0.30722016 0.54782907 12 101395507 101395591 85 - 2.101 2.141 0.135
ENSG00000120805 E006 195.6240537 0.0002790330 0.33275210 0.57142823 12 101395592 101395670 79 - 2.155 2.192 0.123
ENSG00000120805 E007 2.9622678 0.0086251155 0.20881855 0.44044205 12 101396143 101396398 256 - 0.449 0.676 1.045
ENSG00000120805 E008 129.7932347 0.0003220955 0.99650101 0.99994559 12 101396399 101396413 15 - 1.983 1.988 0.017
ENSG00000120805 E009 266.7808206 0.0003795089 0.31028901 0.55076532 12 101396414 101396539 126 - 2.288 2.321 0.112
ENSG00000120805 E010 164.1116574 0.0003230302 0.11611511 0.30934703 12 101396540 101396577 38 - 2.091 2.036 -0.184
ENSG00000120805 E011 0.7013366 0.0328555569 0.62231430   12 101400291 101400381 91 - 0.152 0.243 0.841
ENSG00000120805 E012 277.7702219 0.0007891966 0.01193293 0.06616882 12 101401062 101401173 112 - 2.321 2.247 -0.248
ENSG00000120805 E013 1.7305640 0.0110707734 0.83664734 0.91762882 12 101401174 101401486 313 - 0.353 0.397 0.254
ENSG00000120805 E014 236.1493503 0.0005212320 0.30960761 0.55007630 12 101402865 101402946 82 - 2.245 2.218 -0.091
ENSG00000120805 E015 1.4722579 0.0270318699 0.20696067 0.43814385 12 101403142 101403255 114 - 0.264 0.511 1.424
ENSG00000120805 E016 1.1126724 0.0323071507 1.00000000   12 101403416 101403699 284 - 0.263 0.243 -0.153
ENSG00000120805 E017 2.9759575 0.0075522888 0.50360721 0.70330630 12 101405656 101405843 188 - 0.527 0.397 -0.665
ENSG00000120805 E018 164.7630929 0.0007339440 0.27249305 0.51234144 12 101405844 101405883 40 - 2.095 2.058 -0.123
ENSG00000120805 E019 194.7913674 0.0002862538 0.60113434 0.77091750 12 101405884 101405981 98 - 2.157 2.179 0.075
ENSG00000120805 E020 1.2868997 0.0136968632 0.20994404   12 101407011 101407277 267 - 0.325 0.000 -10.817
ENSG00000120805 E021 0.4654660 0.0277061175 1.00000000   12 101407278 101407377 100 - 0.152 0.000 -9.400
ENSG00000120805 E022 1.1067030 0.0140084836 0.26705093   12 101407378 101407641 264 - 0.295 0.000 -10.623
ENSG00000120805 E023 115.0952012 0.0003899045 0.21691299 0.44976696 12 101407642 101407772 131 - 1.924 1.982 0.193