ENSG00000120742

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239944 ENSG00000120742 HEK293_OSMI2_6hA HEK293_TMG_6hB SERP1 protein_coding protein_coding 42.78035 28.91578 44.9963 5.226551 0.7262786 0.6377711 35.645551 16.339074 41.7821530 3.3506811 1.4415807 1.3540232 0.80190000 0.55903333 0.92810000 0.3690667 1.495552e-09 8.55274e-34   FALSE
ENST00000487153 ENSG00000120742 HEK293_OSMI2_6hA HEK293_TMG_6hB SERP1 protein_coding protein_coding 42.78035 28.91578 44.9963 5.226551 0.7262786 0.6377711 4.547029 10.432030 0.0000000 2.6860732 0.0000000 -10.0281865 0.13301250 0.34763333 0.00000000 -0.3476333 8.552740e-34 8.55274e-34   FALSE
ENST00000491660 ENSG00000120742 HEK293_OSMI2_6hA HEK293_TMG_6hB SERP1 protein_coding protein_coding 42.78035 28.91578 44.9963 5.226551 0.7262786 0.6377711 1.230141 1.663686 0.8814699 0.9049115 0.2927403 -0.9087709 0.03419167 0.07486667 0.01946667 -0.0554000 9.325400e-01 8.55274e-34   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120742 E001 1030.6001913 1.452412106 7.901578e-01 8.906254e-01 3 150541998 150544291 2294 - 2.984 2.949 -0.116
ENSG00000120742 E002 642.4716314 0.880747344 2.851211e-01 5.257171e-01 3 150544292 150544498 207 - 2.545 3.061 1.719
ENSG00000120742 E003 8.7058977 0.003988181 1.298221e-07 4.697802e-06 3 150545397 150545702 306 - 1.044 0.702 -1.320
ENSG00000120742 E004 490.0690556 0.659070877 1.417860e-01 3.501526e-01 3 150545703 150545778 76 - 2.355 2.990 2.116
ENSG00000120742 E005 663.2768431 0.713686743 6.885739e-02 2.225057e-01 3 150546052 150546789 738 - 2.401 3.162 2.533
ENSG00000120742 E006 2.8037848 0.015801782 7.314123e-01 8.550624e-01 3 150546790 150547072 283 - 0.423 0.745 1.469
ENSG00000120742 E007 0.2027342 0.637883573 8.207435e-01   3 150547073 150547177 105 - 0.000 0.183 11.060
ENSG00000120742 E008 14.6261162 1.399070756 4.926832e-01 6.957973e-01 3 150565796 150566384 589 - 1.266 0.650 -2.332
ENSG00000120742 E009 11.1413422 1.358161672 3.650139e-01 5.999590e-01 3 150566385 150566798 414 - 1.163 0.475 -2.771
ENSG00000120742 E010 7.7804530 1.319368987 3.439043e-01 5.815464e-01 3 150566799 150566900 102 - 0.984 0.643 -1.345
ENSG00000120742 E011 11.9827449 0.930680450 2.115096e-01 4.435674e-01 3 150566901 150567106 206 - 1.138 0.871 -0.988
ENSG00000120742 E012 0.8383617 0.252341510 6.633917e-01   3 150583117 150583155 39 - 0.208 0.308 0.748
ENSG00000120742 E013 0.2027342 0.637883573 8.207435e-01   3 150585394 150585492 99 - 0.000 0.183 11.060
ENSG00000120742 E014 7.0346709 0.052881359 7.366565e-02 2.320901e-01 3 150602944 150603228 285 - 0.874 0.882 0.031