ENSG00000120733

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314358 ENSG00000120733 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM3B protein_coding protein_coding 28.99659 28.0656 33.17556 3.698811 0.8384071 0.2412385 13.384288 10.676418 17.922390 1.2485801 1.3206549 0.7467893 0.4553917 0.38596667 0.5389 0.15293333 1.802992e-01 6.395616e-05 FALSE TRUE
ENST00000507996 ENSG00000120733 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM3B protein_coding nonsense_mediated_decay 28.99659 28.0656 33.17556 3.698811 0.8384071 0.2412385 8.678422 13.221948 8.071507 2.0374151 0.6981700 -0.7113292 0.3041125 0.46796667 0.2434 -0.22456667 6.395616e-05 6.395616e-05 FALSE TRUE
ENST00000510866 ENSG00000120733 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM3B protein_coding nonsense_mediated_decay 28.99659 28.0656 33.17556 3.698811 0.8384071 0.2412385 1.404864 1.006692 3.563577 0.5045102 0.7538746 1.8134862 0.0471500 0.03933333 0.1087 0.06936667 6.867760e-01 6.395616e-05 FALSE TRUE
ENST00000542866 ENSG00000120733 HEK293_OSMI2_6hA HEK293_TMG_6hB KDM3B protein_coding protein_coding 28.99659 28.0656 33.17556 3.698811 0.8384071 0.2412385 2.835580 1.152901 0.000000 1.1529015 0.0000000 -6.8615851 0.1012333 0.03533333 0.0000 -0.03533333 8.929953e-01 6.395616e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120733 E001 0.0000000       5 138352685 138352762 78 +      
ENSG00000120733 E002 27.9685344 0.0012687891 8.230942e-01 9.097803e-01 5 138352763 138352987 225 + 1.458 1.471 0.044
ENSG00000120733 E003 72.6772051 0.0005163184 5.913387e-04 6.502391e-03 5 138372674 138372792 119 + 1.919 1.802 -0.393
ENSG00000120733 E004 74.2738478 0.0005443756 4.153786e-06 9.809601e-05 5 138372793 138372841 49 + 1.946 1.780 -0.559
ENSG00000120733 E005 114.7038093 0.0004808548 2.512772e-08 1.077864e-06 5 138375093 138375206 114 + 2.131 1.967 -0.549
ENSG00000120733 E006 122.0943064 0.0026395314 2.115202e-06 5.481611e-05 5 138377720 138377810 91 + 2.157 1.992 -0.555
ENSG00000120733 E007 91.7522041 0.0056060222 7.776273e-05 1.211550e-03 5 138377811 138377825 15 + 2.040 1.860 -0.603
ENSG00000120733 E008 156.9533566 0.0003850233 2.411823e-13 2.801526e-11 5 138379584 138379679 96 + 2.278 2.089 -0.630
ENSG00000120733 E009 96.4160088 0.0005169311 1.209747e-09 6.966526e-08 5 138379680 138379708 29 + 2.074 1.875 -0.668
ENSG00000120733 E010 140.3702446 0.0029688338 3.833072e-06 9.157903e-05 5 138381516 138381590 75 + 2.219 2.062 -0.524
ENSG00000120733 E011 1.9852858 0.0363609128 8.911842e-02 2.621530e-01 5 138381591 138381748 158 + 0.599 0.310 -1.511
ENSG00000120733 E012 183.9940034 0.0005705403 1.097093e-07 4.030975e-06 5 138386022 138386190 169 + 2.321 2.200 -0.404
ENSG00000120733 E013 128.9080697 0.0019552434 1.091874e-02 6.202344e-02 5 138386191 138386288 98 + 2.146 2.078 -0.227
ENSG00000120733 E014 205.9750227 0.0009616074 3.822286e-03 2.815371e-02 5 138386289 138386576 288 + 2.341 2.286 -0.182
ENSG00000120733 E015 70.8466108 0.0005417159 2.658061e-01 5.052366e-01 5 138386577 138386621 45 + 1.822 1.896 0.253
ENSG00000120733 E016 616.2056675 0.0001891339 2.934220e-05 5.294284e-04 5 138391013 138392261 1249 + 2.806 2.772 -0.113
ENSG00000120733 E017 199.4307908 0.0003390633 5.919981e-01 7.650368e-01 5 138393171 138393372 202 + 2.297 2.312 0.049
ENSG00000120733 E018 0.4812263 0.0217681645 5.168508e-01   5 138397878 138398177 300 + 0.113 0.230 1.224
ENSG00000120733 E019 227.5162674 0.0002665106 7.984563e-01 8.954098e-01 5 138398178 138398346 169 + 2.349 2.372 0.075
ENSG00000120733 E020 152.7923856 0.0002791917 6.674290e-01 8.145863e-01 5 138398347 138398392 46 + 2.180 2.196 0.053
ENSG00000120733 E021 230.5651465 0.0002116556 2.266442e-01 4.613377e-01 5 138399860 138400012 153 + 2.364 2.364 -0.001
ENSG00000120733 E022 188.6032245 0.0002983666 2.938575e-02 1.255251e-01 5 138415132 138415239 108 + 2.291 2.261 -0.099
ENSG00000120733 E023 189.9746821 0.0002787776 4.935613e-01 6.963193e-01 5 138417483 138417610 128 + 2.275 2.285 0.034
ENSG00000120733 E024 0.1614157 0.0330075353 5.332711e-01   5 138417808 138417987 180 + 0.113 0.000 -9.292
ENSG00000120733 E025 248.1289023 0.0010879196 6.376216e-01 7.954727e-01 5 138418953 138419232 280 + 2.388 2.403 0.052
ENSG00000120733 E026 266.0403806 0.0002835166 4.044571e-01 6.318597e-01 5 138420706 138420962 257 + 2.403 2.450 0.156
ENSG00000120733 E027 170.1692828 0.0003743838 9.014377e-01 9.526039e-01 5 138424075 138424134 60 + 2.224 2.248 0.082
ENSG00000120733 E028 288.8122824 0.0002721074 4.117199e-01 6.373237e-01 5 138424135 138424341 207 + 2.438 2.484 0.154
ENSG00000120733 E029 276.1723911 0.0005876203 4.774667e-02 1.744278e-01 5 138425411 138425582 172 + 2.403 2.478 0.250
ENSG00000120733 E030 6.4750074 0.0041910366 2.448501e-04 3.162788e-03 5 138425583 138425857 275 + 1.035 0.579 -1.818
ENSG00000120733 E031 7.9562696 0.0399269326 2.270439e-02 1.049806e-01 5 138426741 138426974 234 + 1.078 0.766 -1.182
ENSG00000120733 E032 203.4515588 0.0013994793 3.569375e-02 1.434262e-01 5 138426975 138427065 91 + 2.263 2.355 0.308
ENSG00000120733 E033 237.0128467 0.0002273527 5.429782e-01 7.311944e-01 5 138427189 138427319 131 + 2.356 2.399 0.142
ENSG00000120733 E034 277.7732348 0.0003688998 1.807523e-01 4.049644e-01 5 138427967 138428086 120 + 2.447 2.445 -0.007
ENSG00000120733 E035 289.7720650 0.0003352094 6.051957e-01 7.736488e-01 5 138429826 138429965 140 + 2.454 2.471 0.056
ENSG00000120733 E036 263.2806688 0.0002226074 1.665355e-04 2.295048e-03 5 138430249 138430425 177 + 2.365 2.477 0.374
ENSG00000120733 E037 231.4690741 0.0002590649 5.724195e-09 2.833285e-07 5 138431425 138431559 135 + 2.278 2.445 0.560
ENSG00000120733 E038 1194.9431856 0.0061207187 1.290568e-07 4.673094e-06 5 138435620 138437028 1409 + 2.964 3.177 0.710