ENSG00000120662

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239852 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding nonsense_mediated_decay 5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.4003923 0.3765316 0.66125633 0.05100039 0.20067561 0.7962775 0.08155417 0.20366667 0.07376667 -0.12990000 2.703804e-01 9.471708e-08 TRUE TRUE
ENST00000379477 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding protein_coding 5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.1128566 0.1426001 0.09196518 0.14260008 0.04738137 -0.5816791 0.02995417 0.08866667 0.01056667 -0.07810000 9.819329e-01 9.471708e-08 FALSE TRUE
ENST00000379480 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding protein_coding 5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.3582147 0.2791337 0.49440292 0.11436196 0.12261815 0.8028397 0.07697917 0.17350000 0.05106667 -0.12243333 5.930242e-01 9.471708e-08 FALSE TRUE
ENST00000452359 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding protein_coding 5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.6319851 0.0000000 1.37081138 0.00000000 0.23254395 7.1093725 0.09234583 0.00000000 0.14770000 0.14770000 9.530735e-05 9.471708e-08 FALSE FALSE
ENST00000480434 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding protein_coding 5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.9111746 0.0000000 2.05457288 0.00000000 0.42785097 7.6896995 0.16487500 0.00000000 0.21200000 0.21200000 9.471708e-08 9.471708e-08 FALSE TRUE
ENST00000492827 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding processed_transcript 5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.4744234 0.3379946 0.67756773 0.24833507 0.31436750 0.9824369 0.10402500 0.14550000 0.07200000 -0.07350000 8.998062e-01 9.471708e-08   FALSE
ENST00000498245 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding processed_transcript 5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.5283203 0.1712674 1.16653280 0.06776207 0.22903961 2.6983498 0.08592083 0.09703333 0.12060000 0.02356667 8.213440e-01 9.471708e-08   FALSE
MSTRG.8642.4 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding   5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.5949278 0.0000000 1.05360235 0.00000000 0.26907464 6.7328151 0.10827500 0.00000000 0.10826667 0.10826667 3.414382e-04 9.471708e-08 FALSE TRUE
MSTRG.8642.8 ENSG00000120662 HEK293_OSMI2_6hA HEK293_TMG_6hB MTRF1 protein_coding   5.399648 1.906878 9.50213 0.343358 0.8031994 2.31101 0.3864819 0.3926904 0.74857271 0.12648248 0.18183386 0.9136163 0.09340000 0.19706667 0.08110000 -0.11596667 2.294538e-01 9.471708e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120662 E001 4.8486226 0.0163768062 0.058747641 0.19996594 13 41216369 41216872 504 - 0.625 0.903 1.120
ENSG00000120662 E002 1.4167724 0.0244213296 0.190869610 0.41798692 13 41216873 41216873 1 - 0.278 0.521 1.373
ENSG00000120662 E003 3.4088353 0.0382228915 0.704329960 0.83835476 13 41216874 41216974 101 - 0.585 0.651 0.286
ENSG00000120662 E004 3.3568478 0.0090535190 0.615647107 0.78077743 13 41216975 41217057 83 - 0.566 0.652 0.380
ENSG00000120662 E005 1.8210235 0.0121989077 0.789901668 0.89050486 13 41217058 41217059 2 - 0.386 0.439 0.287
ENSG00000120662 E006 3.2082438 0.0079620654 0.903817798 0.95381616 13 41217060 41217121 62 - 0.566 0.592 0.115
ENSG00000120662 E007 7.3365765 0.0047598827 0.494178633 0.69682568 13 41217122 41217228 107 - 0.839 0.932 0.356
ENSG00000120662 E008 0.1426347 0.0315135945 1.000000000   13 41220537 41220643 107 - 0.071 0.000 -8.748
ENSG00000120662 E009 11.6321042 0.0055030756 0.058649318 0.19974510 13 41223256 41223354 99 - 0.989 1.191 0.731
ENSG00000120662 E010 16.0623032 0.0035096218 0.015771977 0.08099073 13 41226432 41226568 137 - 1.107 1.330 0.789
ENSG00000120662 E011 0.1426347 0.0315135945 1.000000000   13 41226569 41226569 1 - 0.071 0.000 -8.748
ENSG00000120662 E012 4.9553033 0.0053490251 0.515365871 0.71188836 13 41227000 41227121 122 - 0.693 0.795 0.412
ENSG00000120662 E013 4.2750061 0.0589154773 0.048899240 0.17700555 13 41227122 41227245 124 - 0.547 0.904 1.475
ENSG00000120662 E014 15.9920837 0.0441947769 0.046120029 0.17029204 13 41233890 41234007 118 - 1.093 1.357 0.933
ENSG00000120662 E015 17.6922388 0.0035735665 0.007076421 0.04497022 13 41240261 41240433 173 - 1.147 1.384 0.832
ENSG00000120662 E016 0.3453689 0.0314224485 0.390975559   13 41252282 41252283 2 - 0.071 0.200 1.706
ENSG00000120662 E017 13.3378700 0.0027769220 0.608377334 0.77582524 13 41252284 41252644 361 - 1.107 1.060 -0.172
ENSG00000120662 E018 13.5499339 0.0040402999 0.529463566 0.72167010 13 41252645 41252663 19 - 1.119 1.059 -0.219
ENSG00000120662 E019 19.0149410 0.0269849790 0.612006562 0.77819051 13 41252664 41252704 41 - 1.254 1.202 -0.186
ENSG00000120662 E020 20.6823663 0.0020083282 0.296648882 0.53715303 13 41252705 41252752 48 - 1.292 1.207 -0.299
ENSG00000120662 E021 25.6678977 0.0015153526 0.225196959 0.45960922 13 41252949 41253030 82 - 1.381 1.293 -0.309
ENSG00000120662 E022 23.9406054 0.0023450974 0.039319171 0.15303053 13 41254529 41254620 92 - 1.362 1.192 -0.597
ENSG00000120662 E023 2.7869742 0.2026962189 0.376481702 0.60941791 13 41257673 41257755 83 - 0.450 0.668 1.003
ENSG00000120662 E024 1.9414103 0.1847260597 0.449823385 0.66556037 13 41257756 41257796 41 - 0.356 0.534 0.931
ENSG00000120662 E025 0.3206185 0.0274424043 0.802508921   13 41257797 41257797 1 - 0.133 0.000 -9.676
ENSG00000120662 E026 58.9954319 0.0009428697 0.006430805 0.04182843 13 41260493 41260915 423 - 1.738 1.602 -0.461
ENSG00000120662 E027 4.6092440 0.1359032942 0.634290304 0.79311957 13 41261333 41261432 100 - 0.649 0.796 0.604
ENSG00000120662 E028 9.2313278 0.0056349046 0.853139632 0.92672172 13 41261433 41261690 258 - 0.948 0.933 -0.056
ENSG00000120662 E029 12.4415901 0.0747919087 0.603255864 0.77237966 13 41261691 41261825 135 - 1.032 1.149 0.424
ENSG00000120662 E030 4.2471423 0.0068958151 0.293358672 0.53406835 13 41262048 41262214 167 - 0.694 0.522 -0.759
ENSG00000120662 E031 11.4479764 0.0027597918 0.984181599 0.99394411 13 41262215 41262331 117 - 1.028 1.037 0.034
ENSG00000120662 E032 7.6370692 0.0789672323 0.303359572 0.54390355 13 41262411 41262481 71 - 0.904 0.755 -0.583
ENSG00000120662 E033 1.7335847 0.0121819423 0.029119304 0.12471319 13 41263273 41263274 2 - 0.472 0.000 -11.719
ENSG00000120662 E034 9.2198463 0.0041966847 0.021450119 0.10081152 13 41263275 41263484 210 - 1.013 0.705 -1.192
ENSG00000120662 E035 12.2483707 0.0026893700 0.139182855 0.34630131 13 41263485 41263566 82 - 1.095 0.933 -0.598
ENSG00000120662 E036 3.5845355 0.0086037877 0.238429800 0.47483804 13 41263567 41263681 115 - 0.643 0.439 -0.961
ENSG00000120662 E037 0.0000000       13 41264411 41264442 32 -