ENSG00000120616

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319778 ENSG00000120616 HEK293_OSMI2_6hA HEK293_TMG_6hB EPC1 protein_coding protein_coding 6.663098 2.981688 10.98501 0.3826172 0.8651851 1.877817 3.6579027 2.2740213 5.3995068 0.38869223 0.3424318 1.2439210 0.56666250 0.75343333 0.49280000 -0.26063333 4.552767e-03 9.243055e-06 FALSE TRUE
ENST00000375110 ENSG00000120616 HEK293_OSMI2_6hA HEK293_TMG_6hB EPC1 protein_coding protein_coding 6.663098 2.981688 10.98501 0.3826172 0.8651851 1.877817 0.8012817 0.0000000 1.2874336 0.00000000 0.1961253 7.0195169 0.10110417 0.00000000 0.11926667 0.11926667 9.243055e-06 9.243055e-06 FALSE TRUE
ENST00000469059 ENSG00000120616 HEK293_OSMI2_6hA HEK293_TMG_6hB EPC1 protein_coding protein_coding 6.663098 2.981688 10.98501 0.3826172 0.8651851 1.877817 0.3353448 0.2429528 0.4017839 0.03203267 0.1010148 0.7030193 0.05801250 0.08340000 0.03793333 -0.04546667 4.505937e-01 9.243055e-06 TRUE FALSE
ENST00000480402 ENSG00000120616 HEK293_OSMI2_6hA HEK293_TMG_6hB EPC1 protein_coding protein_coding 6.663098 2.981688 10.98501 0.3826172 0.8651851 1.877817 0.3903633 0.2332341 0.2036328 0.12626053 0.1058801 -0.1872121 0.08580000 0.08756667 0.01716667 -0.07040000 7.965237e-01 9.243055e-06 TRUE FALSE
ENST00000492710 ENSG00000120616 HEK293_OSMI2_6hA HEK293_TMG_6hB EPC1 protein_coding retained_intron 6.663098 2.981688 10.98501 0.3826172 0.8651851 1.877817 0.4570205 0.0000000 2.0942068 0.00000000 0.7214535 7.7171327 0.05941667 0.00000000 0.18333333 0.18333333 1.392377e-05 9.243055e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120616 E001 90.3706750 0.0007991541 0.298604530 0.53906245 10 32267751 32268480 730 - 1.895 1.972 0.257
ENSG00000120616 E002 55.1993278 0.1399844698 0.155892708 0.37074760 10 32268481 32268930 450 - 1.631 1.847 0.731
ENSG00000120616 E003 44.4443626 0.7422093810 0.236534914 0.47258410 10 32268931 32269135 205 - 1.500 1.810 1.054
ENSG00000120616 E004 50.4757698 0.0126470450 0.135451178 0.34048351 10 32271554 32271713 160 - 1.626 1.758 0.448
ENSG00000120616 E005 66.2926998 0.0006848027 0.049471886 0.17834853 10 32271714 32271917 204 - 1.795 1.737 -0.196
ENSG00000120616 E006 41.0352939 0.0072662300 0.229396623 0.46443112 10 32272026 32272167 142 - 1.591 1.548 -0.146
ENSG00000120616 E007 1.3192282 0.1610425458 0.832732232   10 32272168 32272249 82 - 0.341 0.313 -0.181
ENSG00000120616 E008 5.4112883 0.0055652913 0.498133052 0.69956708 10 32273014 32273082 69 - 0.786 0.719 -0.268
ENSG00000120616 E009 3.6267817 0.0068017420 0.455696182 0.67001988 10 32273083 32273162 80 - 0.656 0.562 -0.414
ENSG00000120616 E010 33.6705293 0.0148850948 0.624509812 0.78701539 10 32273163 32273281 119 - 1.493 1.498 0.019
ENSG00000120616 E011 3.9052037 0.0457385783 0.701339709 0.83647524 10 32273922 32274038 117 - 0.659 0.620 -0.166
ENSG00000120616 E012 4.4945438 0.0073290689 0.019407407 0.09387208 10 32281859 32284697 2839 - 0.785 0.413 -1.679
ENSG00000120616 E013 65.8478709 0.0075995790 0.202465820 0.43271449 10 32284698 32285050 353 - 1.789 1.751 -0.127
ENSG00000120616 E014 2.2321870 0.0092491576 0.004287955 0.03077480 10 32285051 32286693 1643 - 0.574 0.000 -13.147
ENSG00000120616 E015 45.1544935 0.0009329850 0.995797212 0.99948740 10 32286694 32286842 149 - 1.607 1.643 0.124
ENSG00000120616 E016 0.9640683 0.0155421941 0.090239586   10 32286843 32286925 83 - 0.338 0.000 -11.925
ENSG00000120616 E017 31.6010641 0.0013675524 0.382278916 0.61405515 10 32286926 32287015 90 - 1.436 1.530 0.323
ENSG00000120616 E018 47.3884838 0.0008549756 0.246328484 0.48393982 10 32287098 32287274 177 - 1.645 1.616 -0.098
ENSG00000120616 E019 44.7956882 0.0009984641 0.072668011 0.23013600 10 32291163 32291322 160 - 1.631 1.563 -0.234
ENSG00000120616 E020 0.1723744 0.0478920514 0.192013165   10 32291323 32292495 1173 - 0.000 0.185 12.174
ENSG00000120616 E021 42.1205358 0.0115548606 0.049146546 0.17756347 10 32292496 32292644 149 - 1.612 1.502 -0.375
ENSG00000120616 E022 44.6433549 0.0072914566 0.026287276 0.11616706 10 32292988 32293194 207 - 1.640 1.523 -0.398
ENSG00000120616 E023 29.0792361 0.0258693093 0.257841594 0.49660499 10 32293592 32293737 146 - 1.449 1.382 -0.231
ENSG00000120616 E024 33.6906033 0.0015082978 0.423575052 0.64629034 10 32305772 32305931 160 - 1.497 1.480 -0.059
ENSG00000120616 E025 8.4252925 0.1492776563 0.181782914 0.40633532 10 32345112 32345562 451 - 0.808 1.139 1.233
ENSG00000120616 E026 4.1453783 0.0546355196 0.495045053 0.69748563 10 32345563 32345623 61 - 0.618 0.765 0.614
ENSG00000120616 E027 34.6751981 0.0597476655 0.028944526 0.12419643 10 32346763 32347218 456 - 1.405 1.693 0.984
ENSG00000120616 E028 0.0000000       10 32377113 32377435 323 -      
ENSG00000120616 E029 4.3125617 0.0354094512 0.009740377 0.05700590 10 32378491 32378798 308 - 0.773 0.313 -2.222