ENSG00000120458

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239614 ENSG00000120458 HEK293_OSMI2_6hA HEK293_TMG_6hB MSANTD2 protein_coding protein_coding 5.666709 4.735394 6.331459 0.4589776 0.1368402 0.418287 0.3673772 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.09997083 0.00000000 0.00000000 0.00000000   0.0003487104 FALSE TRUE
ENST00000374979 ENSG00000120458 HEK293_OSMI2_6hA HEK293_TMG_6hB MSANTD2 protein_coding protein_coding 5.666709 4.735394 6.331459 0.4589776 0.1368402 0.418287 0.6981541 0.5991478 0.9426691 0.12645202 0.14602776 0.6451828 0.12511250 0.12673333 0.14813333 0.02140000 0.9240027228 0.0003487104 FALSE TRUE
ENST00000526629 ENSG00000120458 HEK293_OSMI2_6hA HEK293_TMG_6hB MSANTD2 protein_coding protein_coding 5.666709 4.735394 6.331459 0.4589776 0.1368402 0.418287 1.8879887 1.4866346 2.3100287 0.40414755 0.20460332 0.6324206 0.32033750 0.30976667 0.36533333 0.05556667 0.8708391699 0.0003487104 FALSE TRUE
ENST00000650095 ENSG00000120458 HEK293_OSMI2_6hA HEK293_TMG_6hB MSANTD2 protein_coding processed_transcript 5.666709 4.735394 6.331459 0.4589776 0.1368402 0.418287 0.9202606 0.7592835 1.1068558 0.06195519 0.20079535 0.5378557 0.15201250 0.16350000 0.17453333 0.01103333 0.9719590635 0.0003487104 FALSE TRUE
MSTRG.6500.11 ENSG00000120458 HEK293_OSMI2_6hA HEK293_TMG_6hB MSANTD2 protein_coding   5.666709 4.735394 6.331459 0.4589776 0.1368402 0.418287 0.1362350 0.3615237 0.0000000 0.23256074 0.00000000 -5.2153822 0.03583750 0.08826667 0.00000000 -0.08826667 0.3553434907 0.0003487104 FALSE TRUE
MSTRG.6500.15 ENSG00000120458 HEK293_OSMI2_6hA HEK293_TMG_6hB MSANTD2 protein_coding   5.666709 4.735394 6.331459 0.4589776 0.1368402 0.418287 0.1046372 0.0000000 0.3247861 0.00000000 0.07289396 5.0651676 0.01682917 0.00000000 0.05113333 0.05113333 0.0003487104 0.0003487104 FALSE FALSE
MSTRG.6500.8 ENSG00000120458 HEK293_OSMI2_6hA HEK293_TMG_6hB MSANTD2 protein_coding   5.666709 4.735394 6.331459 0.4589776 0.1368402 0.418287 1.0781344 1.1140228 1.3317740 0.37922113 0.23769815 0.2554704 0.16937917 0.23093333 0.21130000 -0.01963333 0.9865236660 0.0003487104 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120458 E001 1.5481881 0.012460869 0.40565900 0.63279821 11 124765547 124765574 28 - 0.340 0.491 0.819
ENSG00000120458 E002 1.3267903 0.033101692 0.86611989   11 124766498 124766527 30 - 0.341 0.380 0.231
ENSG00000120458 E003 4.5543969 0.008990110 0.14605672 0.35645823 11 124766528 124766615 88 - 0.631 0.842 0.860
ENSG00000120458 E004 26.6260128 0.011556874 0.07011798 0.22502972 11 124766616 124766946 331 - 1.359 1.508 0.517
ENSG00000120458 E005 108.0106743 0.020671327 0.28648122 0.52716604 11 124766947 124767493 547 - 2.005 2.070 0.217
ENSG00000120458 E006 74.2981346 0.003478124 0.22931527 0.46434615 11 124767494 124767833 340 - 1.849 1.911 0.210
ENSG00000120458 E007 47.1073780 0.004045239 0.97512221 0.98942557 11 124767834 124767947 114 - 1.679 1.691 0.044
ENSG00000120458 E008 39.2823135 0.002806402 0.47584994 0.68410805 11 124767948 124768028 81 - 1.624 1.595 -0.097
ENSG00000120458 E009 35.9726852 0.001152036 0.59593711 0.76769600 11 124772994 124773054 61 - 1.579 1.560 -0.064
ENSG00000120458 E010 0.6258862 0.022460655 0.25433398   11 124773055 124773380 326 - 0.113 0.311 1.816
ENSG00000120458 E011 41.9581345 0.001090437 0.02084609 0.09883233 11 124774719 124774803 85 - 1.681 1.569 -0.384
ENSG00000120458 E012 28.4627387 0.002004982 0.02652101 0.11683515 11 124774804 124774818 15 - 1.524 1.388 -0.469
ENSG00000120458 E013 20.8490645 0.002318176 0.01793816 0.08883705 11 124774819 124774831 13 - 1.405 1.233 -0.599
ENSG00000120458 E014 36.9283977 0.001519861 0.82038320 0.90831998 11 124774832 124774974 143 - 1.575 1.573 -0.009
ENSG00000120458 E015 31.2236417 0.019375028 0.68711093 0.82723137 11 124774975 124775508 534 - 1.513 1.499 -0.047
ENSG00000120458 E016 42.2779876 0.036843889 0.29280784 0.53351829 11 124775509 124776242 734 - 1.665 1.598 -0.226
ENSG00000120458 E017 6.6896735 0.005339337 0.16496625 0.38394142 11 124779004 124779049 46 - 0.956 0.795 -0.616
ENSG00000120458 E018 8.1701566 0.041213902 0.81702185 0.90644294 11 124779050 124779139 90 - 0.940 0.989 0.184
ENSG00000120458 E019 3.8450454 0.031425278 0.04437618 0.16602622 11 124783171 124783332 162 - 0.488 0.823 1.442
ENSG00000120458 E020 44.4568858 0.010644184 0.23923945 0.47569397 11 124799871 124800706 836 - 1.618 1.710 0.314