ENSG00000120071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432791 ENSG00000120071 HEK293_OSMI2_6hA HEK293_TMG_6hB KANSL1 protein_coding protein_coding 13.72139 13.01181 15.93454 0.1563973 0.5834843 0.2921326 0.8305728 1.0335145 0.8834626 0.20642953 0.19538615 -0.2239714 0.05940000 0.07910000 0.05623333 -0.02286667 7.850449e-01 1.579512e-06 FALSE TRUE
ENST00000572904 ENSG00000120071 HEK293_OSMI2_6hA HEK293_TMG_6hB KANSL1 protein_coding protein_coding 13.72139 13.01181 15.93454 0.1563973 0.5834843 0.2921326 5.9955091 7.2760819 5.2805607 0.80624455 1.38361052 -0.4617226 0.46318333 0.55860000 0.33006667 -0.22853333 3.666265e-01 1.579512e-06 FALSE TRUE
ENST00000574590 ENSG00000120071 HEK293_OSMI2_6hA HEK293_TMG_6hB KANSL1 protein_coding protein_coding 13.72139 13.01181 15.93454 0.1563973 0.5834843 0.2921326 0.9469077 0.9582342 1.9794277 0.39445071 0.14056027 1.0389255 0.06420833 0.07296667 0.12416667 0.05120000 5.567828e-01 1.579512e-06 FALSE TRUE
ENST00000575318 ENSG00000120071 HEK293_OSMI2_6hA HEK293_TMG_6hB KANSL1 protein_coding protein_coding 13.72139 13.01181 15.93454 0.1563973 0.5834843 0.2921326 0.8868895 0.8272769 0.0000000 0.28042248 0.00000000 -6.3876330 0.07323333 0.06380000 0.00000000 -0.06380000 1.579512e-06 1.579512e-06 FALSE TRUE
ENST00000639531 ENSG00000120071 HEK293_OSMI2_6hA HEK293_TMG_6hB KANSL1 protein_coding protein_coding 13.72139 13.01181 15.93454 0.1563973 0.5834843 0.2921326 1.0753278 0.3830051 1.8976050 0.08785954 0.07402508 2.2791426 0.06843750 0.02960000 0.11906667 0.08946667 8.443831e-04 1.579512e-06 FALSE TRUE
ENST00000639853 ENSG00000120071 HEK293_OSMI2_6hA HEK293_TMG_6hB KANSL1 protein_coding protein_coding 13.72139 13.01181 15.93454 0.1563973 0.5834843 0.2921326 0.5822283 0.3546888 1.4734750 0.14797077 0.22244525 2.0242430 0.03863750 0.02723333 0.09263333 0.06540000 1.701696e-01 1.579512e-06 FALSE TRUE
ENST00000648792 ENSG00000120071 HEK293_OSMI2_6hA HEK293_TMG_6hB KANSL1 protein_coding protein_coding 13.72139 13.01181 15.93454 0.1563973 0.5834843 0.2921326 0.8520835 0.2802235 1.9594562 0.28022351 0.53804124 2.7625610 0.05620000 0.02186667 0.12360000 0.10173333 2.269572e-01 1.579512e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120071 E001 0.6958470 0.1692001516 0.069665733   17 46029916 46029916 1 - 0.000 0.388 13.732
ENSG00000120071 E002 0.6958470 0.1692001516 0.069665733   17 46029917 46029917 1 - 0.000 0.388 13.749
ENSG00000120071 E003 3.3061249 0.0101107719 0.354240183 0.59104301 17 46029918 46029955 38 - 0.537 0.713 0.771
ENSG00000120071 E004 5.6938921 0.0068528168 0.122033004 0.31907638 17 46029956 46029984 29 - 0.685 0.927 0.956
ENSG00000120071 E005 344.1655307 1.3840326073 0.356414010 0.59286708 17 46029985 46031073 1089 - 2.343 2.650 1.025
ENSG00000120071 E006 215.0338686 1.2121692122 0.350982224 0.58811007 17 46031074 46031653 580 - 2.152 2.441 0.964
ENSG00000120071 E007 53.5468868 0.5141490405 0.304675179 0.54524894 17 46031654 46031703 50 - 1.612 1.817 0.693
ENSG00000120071 E008 5.0541072 0.5161275337 0.774410073 0.88139374 17 46031704 46032046 343 - 0.784 0.783 -0.003
ENSG00000120071 E009 59.4472311 0.5730643468 0.363556659 0.59864721 17 46032047 46032116 70 - 1.683 1.847 0.555
ENSG00000120071 E010 45.0480277 0.4599868216 0.316595425 0.55659282 17 46032117 46032164 48 - 1.554 1.736 0.618
ENSG00000120071 E011 28.1516935 0.3105879951 0.342338114 0.58006371 17 46032165 46032167 3 - 1.374 1.528 0.530
ENSG00000120071 E012 30.7080785 0.3379304385 0.332941380 0.57158993 17 46032168 46032185 18 - 1.405 1.567 0.557
ENSG00000120071 E013 28.0131906 0.3120026977 0.346861106 0.58444451 17 46032186 46032219 34 - 1.373 1.525 0.522
ENSG00000120071 E014 26.9342070 0.2703507456 0.251047867 0.48911573 17 46032220 46032256 37 - 1.322 1.528 0.714
ENSG00000120071 E015 20.4807045 0.1923264861 0.171342854 0.39229322 17 46032257 46032267 11 - 1.176 1.432 0.896
ENSG00000120071 E016 26.0187980 0.2441417189 0.164719967 0.38364176 17 46032268 46032294 27 - 1.275 1.530 0.881
ENSG00000120071 E017 20.4427358 0.1270586564 0.066559132 0.21731628 17 46032295 46032299 5 - 1.138 1.446 1.080
ENSG00000120071 E018 7.9623214 0.3182478079 0.706351155 0.83957188 17 46032300 46032566 267 - 0.850 1.025 0.660
ENSG00000120071 E019 4.9961579 0.0882656969 0.646491187 0.80116957 17 46033045 46033079 35 - 0.812 0.745 -0.270
ENSG00000120071 E020 24.0935827 0.2365461275 0.211125770 0.44310970 17 46033080 46033098 19 - 1.268 1.485 0.751
ENSG00000120071 E021 49.1437430 0.5148666618 0.379461088 0.61177406 17 46033099 46033192 94 - 1.616 1.757 0.478
ENSG00000120071 E022 45.3897696 0.4923529070 0.394597352 0.62401939 17 46033403 46033460 58 - 1.589 1.720 0.443
ENSG00000120071 E023 1.7434752 0.2407199007 0.872849367 0.93751714 17 46033461 46033469 9 - 0.434 0.448 0.073
ENSG00000120071 E024 2.0052115 0.0792944045 0.751078609 0.86743031 17 46033470 46033512 43 - 0.437 0.528 0.453
ENSG00000120071 E025 33.0169925 0.4084610662 0.478302059 0.68596608 17 46034161 46034168 8 - 1.486 1.565 0.269
ENSG00000120071 E026 76.7234963 0.6846600841 0.428737254 0.65014168 17 46034169 46034279 111 - 1.821 1.939 0.398
ENSG00000120071 E027 41.0784733 0.4770966079 0.432413722 0.65304089 17 46034280 46034282 3 - 1.561 1.668 0.364
ENSG00000120071 E028 35.8554461 0.4321580804 0.437933974 0.65716462 17 46034283 46034285 3 - 1.507 1.609 0.349
ENSG00000120071 E029 3.4469743 0.0615287494 0.865966710 0.93370709 17 46034286 46034368 83 - 0.614 0.666 0.225
ENSG00000120071 E030 3.4876727 0.1162251852 0.417419638 0.64168539 17 46034369 46034431 63 - 0.532 0.724 0.835
ENSG00000120071 E031 2.3438556 0.3154070127 0.349653875 0.58695341 17 46034432 46034460 29 - 0.372 0.615 1.208
ENSG00000120071 E032 5.4518554 0.1338278637 0.293837143 0.53448196 17 46034461 46034763 303 - 0.646 0.906 1.042
ENSG00000120071 E033 13.8785547 0.2839447370 0.719892360 0.84812227 17 46034764 46035924 1161 - 1.129 1.205 0.272
ENSG00000120071 E034 13.0537967 0.1209025712 0.134639736 0.33911138 17 46037325 46038537 1213 - 1.231 1.057 -0.622
ENSG00000120071 E035 80.3434459 0.0006783848 0.766173268 0.87633314 17 46038538 46038635 98 - 1.883 1.937 0.184
ENSG00000120071 E036 66.6776166 0.0006819913 0.313317882 0.55353532 17 46038636 46038686 51 - 1.780 1.869 0.300
ENSG00000120071 E037 2.7872166 0.0137459391 0.803826809 0.89854289 17 46038687 46039026 340 - 0.578 0.567 -0.050
ENSG00000120071 E038 103.5973982 0.0188814317 0.245486750 0.48294786 17 46039027 46039215 189 - 2.030 2.008 -0.074
ENSG00000120071 E039 3.7386246 0.1774273469 0.107209812 0.29435899 17 46039216 46039701 486 - 0.820 0.520 -1.278
ENSG00000120071 E040 121.2582280 0.0297051853 0.186935888 0.41296005 17 46039702 46039869 168 - 2.112 2.062 -0.168
ENSG00000120071 E041 54.6038238 0.0166922806 0.085510693 0.25554195 17 46039870 46039884 15 - 1.782 1.708 -0.250
ENSG00000120071 E042 7.3927765 0.2413494528 0.999524559 1.00000000 17 46039885 46046121 6237 - 0.820 0.987 0.634
ENSG00000120071 E043 0.6785387 0.5216004450 0.697245614   17 46049399 46050532 1134 - 0.130 0.283 1.391
ENSG00000120071 E044 92.2043829 0.0384502327 0.465870493 0.67720023 17 46050533 46050649 117 - 1.971 1.964 -0.025
ENSG00000120071 E045 64.2447024 0.0323144252 0.927369163 0.96574937 17 46050650 46050704 55 - 1.780 1.836 0.190
ENSG00000120071 E046 125.6212173 0.0506738431 0.143494696 0.35264315 17 46066537 46066732 196 - 2.151 2.053 -0.329
ENSG00000120071 E047 92.9559308 0.0399590659 0.056932895 0.19588576 17 46067549 46067667 119 - 2.037 1.908 -0.431
ENSG00000120071 E048 77.5600295 0.0116053643 0.034478761 0.14015239 17 46082441 46082542 102 - 1.934 1.857 -0.260
ENSG00000120071 E049 0.0000000       17 46088428 46088680 253 -      
ENSG00000120071 E050 0.3206185 0.0251801959 0.138133740   17 46092870 46094507 1638 - 0.230 0.000 -12.965
ENSG00000120071 E051 1.7745050 0.0108647759 0.276797934 0.51679518 17 46094508 46094559 52 - 0.311 0.529 1.185
ENSG00000120071 E052 103.7212094 0.0325669426 0.137584110 0.34382463 17 46094560 46094701 142 - 2.055 1.984 -0.238
ENSG00000120071 E053 0.2027342 0.0423005756 0.631353795   17 46119967 46120049 83 - 0.000 0.114 11.480
ENSG00000120071 E054 0.0000000       17 46121324 46121338 15 -      
ENSG00000120071 E055 0.0000000       17 46148125 46148239 115 -      
ENSG00000120071 E056 0.3807181 0.0577351849 0.844627802   17 46152904 46152966 63 - 0.130 0.114 -0.225
ENSG00000120071 E057 0.0000000       17 46156774 46156895 122 -      
ENSG00000120071 E058 1.4537666 0.1970913776 0.789706180 0.89038821 17 46169531 46169605 75 - 0.313 0.407 0.558
ENSG00000120071 E059 1.0124014 0.0851967980 0.275805375   17 46170277 46170854 578 - 0.381 0.203 -1.237
ENSG00000120071 E060 438.8239012 0.0412683273 0.006937146 0.04434066 17 46170855 46172116 1262 - 2.723 2.560 -0.543
ENSG00000120071 E061 52.6372444 0.0246797818 0.036685565 0.14604652 17 46172117 46172232 116 - 1.792 1.668 -0.421
ENSG00000120071 E062 1.3501356 0.0172409049 0.291168094   17 46192419 46192822 404 - 0.439 0.278 -0.962
ENSG00000120071 E063 13.6583502 0.0670237795 0.961788982 0.98290290 17 46192823 46193429 607 - 1.126 1.200 0.264
ENSG00000120071 E064 0.4043710 0.0733804436 0.755119640   17 46193750 46193901 152 - 0.130 0.201 0.762
ENSG00000120071 E065 0.0000000       17 46221186 46223670 2485 -      
ENSG00000120071 E066 24.9100296 0.0403331075 0.038126757 0.14994906 17 46223671 46223804 134 - 1.504 1.317 -0.647
ENSG00000120071 E067 6.8110192 0.1328090763 0.237847027 0.47408275 17 46224561 46224902 342 - 0.980 0.788 -0.736
ENSG00000120071 E068 7.9456207 0.0301222828 0.021652817 0.10145480 17 46225341 46225389 49 - 1.073 0.805 -1.008