ENSG00000120008

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263461 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding protein_coding 21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 9.9560231 3.1595656 15.9354095 1.11558180 0.7576405 2.3307841 0.39565417 0.28340000 0.45346667 0.17006667 5.226926e-01 6.819171e-24 FALSE TRUE
ENST00000478567 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding processed_transcript 21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 0.8887283 0.0000000 3.2061244 0.00000000 0.5298649 8.3291794 0.03079167 0.00000000 0.09066667 0.09066667 7.050758e-11 6.819171e-24 TRUE TRUE
ENST00000497136 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding nonsense_mediated_decay 21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 3.0501356 1.7999217 5.0514067 0.29261261 0.3614967 1.4836111 0.15459167 0.17800000 0.14443333 -0.03356667 9.004650e-01 6.819171e-24 TRUE TRUE
ENST00000603658 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding retained_intron 21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 2.1111423 1.0915471 3.1790448 0.46917256 0.3322415 1.5335932 0.10425417 0.11530000 0.09043333 -0.02486667 1.000000e+00 6.819171e-24 FALSE FALSE
ENST00000604714 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding processed_transcript 21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 0.9506425 0.6905374 1.2476044 0.06636349 0.1315708 0.8441442 0.05680000 0.06676667 0.03563333 -0.03113333 3.066643e-01 6.819171e-24 FALSE FALSE
ENST00000605202 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding processed_transcript 21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 0.8113678 0.0000000 2.0100808 0.00000000 0.2701248 7.6582692 0.02536250 0.00000000 0.05716667 0.05716667 4.906647e-09 6.819171e-24   FALSE
ENST00000605543 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding nonsense_mediated_decay 21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 0.7368468 1.0869562 0.0000000 0.73633151 0.0000000 -6.7773622 0.07068750 0.09353333 0.00000000 -0.09353333 1.756979e-01 6.819171e-24 FALSE TRUE
MSTRG.4740.18 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding   21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 0.7173015 0.8511319 0.7761497 0.30900063 0.3330024 -0.1314301 0.05237083 0.07640000 0.02173333 -0.05466667 2.547266e-01 6.819171e-24 TRUE TRUE
MSTRG.4740.9 ENSG00000120008 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR11 protein_coding   21.35278 10.57044 35.1247 1.034202 0.8433514 1.731497 0.4594880 1.1838824 0.0000000 0.07346602 0.0000000 -6.8995169 0.03809583 0.11323333 0.00000000 -0.11323333 6.819171e-24 6.819171e-24 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000120008 E001 0.6268817 0.1477745389 2.691113e-01   10 120851305 120851312 8 + 0.255 0.000 -11.619
ENSG00000120008 E002 0.6268817 0.1477745389 2.691113e-01   10 120851313 120851316 4 + 0.255 0.000 -11.567
ENSG00000120008 E003 3.1737000 0.4040570987 9.658549e-01 9.848355e-01 10 120851317 120851361 45 + 0.610 0.551 -0.264
ENSG00000120008 E004 12.2413452 0.6051763830 7.433621e-01 8.626056e-01 10 120851362 120851391 30 + 1.096 1.047 -0.177
ENSG00000120008 E005 16.6756354 0.6934049536 7.622138e-01 8.739690e-01 10 120851392 120851403 12 + 1.222 1.163 -0.209
ENSG00000120008 E006 34.3472124 0.1690118010 6.146572e-01 7.800032e-01 10 120851404 120851486 83 + 1.496 1.531 0.120
ENSG00000120008 E007 30.9410564 0.0797729855 9.599571e-01 9.818470e-01 10 120851487 120851506 20 + 1.474 1.435 -0.133
ENSG00000120008 E008 6.2640749 0.0268679290 1.697166e-01 3.901214e-01 10 120851507 120851527 21 + 0.880 0.665 -0.860
ENSG00000120008 E009 4.8479724 0.0112158825 1.289662e-01 3.301735e-01 10 120851528 120851591 64 + 0.793 0.556 -1.004
ENSG00000120008 E010 5.8547307 0.0046169939 1.132410e-02 6.370389e-02 10 120851781 120852523 743 + 0.881 0.488 -1.669
ENSG00000120008 E011 53.1446176 0.0142740484 3.470877e-01 5.846169e-01 10 120852524 120852603 80 + 1.712 1.641 -0.239
ENSG00000120008 E012 39.1452114 0.0010324819 1.444767e-01 3.541187e-01 10 120852604 120852615 12 + 1.585 1.500 -0.289
ENSG00000120008 E013 42.4567419 0.0038082516 5.155426e-02 1.834335e-01 10 120852616 120852635 20 + 1.627 1.501 -0.432
ENSG00000120008 E014 0.8815333 0.0439247775 6.925527e-01   10 120856082 120856130 49 + 0.256 0.182 -0.625
ENSG00000120008 E015 66.7444795 0.0016854101 1.027823e-03 1.012812e-02 10 120858643 120858703 61 + 1.831 1.664 -0.565
ENSG00000120008 E016 80.0799668 0.0006392077 2.677814e-05 4.890884e-04 10 120858704 120858796 93 + 1.913 1.724 -0.638
ENSG00000120008 E017 109.7076798 0.0067089149 5.988697e-04 6.568189e-03 10 120860109 120860282 174 + 2.045 1.855 -0.641
ENSG00000120008 E018 1.1552237 0.0146572484 3.916043e-01   10 120860283 120860310 28 + 0.343 0.182 -1.210
ENSG00000120008 E019 3.9501767 0.0063654115 3.514345e-01 5.885765e-01 10 120862450 120862734 285 + 0.700 0.556 -0.626
ENSG00000120008 E020 103.4977904 0.0037540218 1.012564e-03 1.000621e-02 10 120862735 120862921 187 + 2.013 1.857 -0.525
ENSG00000120008 E021 92.5011078 0.0285191530 3.403464e-01 5.782466e-01 10 120865047 120865212 166 + 1.950 1.861 -0.298
ENSG00000120008 E022 96.0584945 0.0017611924 4.449465e-01 6.621056e-01 10 120865630 120865744 115 + 1.949 1.924 -0.083
ENSG00000120008 E023 57.6484841 0.0007244395 8.184491e-01 9.071367e-01 10 120866569 120866574 6 + 1.723 1.720 -0.012
ENSG00000120008 E024 131.2674645 0.0003060263 3.678142e-02 1.463389e-01 10 120866575 120866764 190 + 2.095 2.031 -0.214
ENSG00000120008 E025 33.2972240 0.0043627490 6.473825e-01 8.017442e-01 10 120867066 120867068 3 + 1.505 1.484 -0.074
ENSG00000120008 E026 85.3222079 0.0030014082 3.729949e-01 6.065121e-01 10 120867069 120867169 101 + 1.903 1.871 -0.106
ENSG00000120008 E027 0.6787990 0.0444505131 2.291392e-01   10 120868663 120868761 99 + 0.256 0.000 -11.575
ENSG00000120008 E028 89.3986027 0.0012986500 6.835903e-02 2.214220e-01 10 120871170 120871234 65 + 1.932 1.861 -0.241
ENSG00000120008 E029 106.8251466 0.0010370339 3.026438e-01 5.432049e-01 10 120871235 120871346 112 + 1.998 1.966 -0.109
ENSG00000120008 E030 104.1526864 0.0004809806 8.755706e-04 8.894659e-03 10 120873839 120873923 85 + 2.011 1.886 -0.421
ENSG00000120008 E031 131.5722010 0.0003714666 1.736534e-03 1.527489e-02 10 120878353 120878459 107 + 2.104 2.001 -0.344
ENSG00000120008 E032 8.3461648 0.0562191566 2.681227e-01 5.077943e-01 10 120879005 120880562 1558 + 0.979 0.793 -0.714
ENSG00000120008 E033 81.4165385 0.0005102502 9.511312e-01 9.775408e-01 10 120880826 120880901 76 + 1.869 1.880 0.038
ENSG00000120008 E034 104.3184586 0.0004228113 9.145629e-01 9.593818e-01 10 120883780 120883888 109 + 1.975 1.987 0.043
ENSG00000120008 E035 0.7930990 0.1242171740 7.079632e-01   10 120885010 120885125 116 + 0.257 0.181 -0.645
ENSG00000120008 E036 79.8474484 0.0005854873 9.409740e-01 9.727413e-01 10 120885814 120885867 54 + 1.859 1.865 0.019
ENSG00000120008 E037 95.7618098 0.0050034210 3.023121e-01 5.428900e-01 10 120885868 120885938 71 + 1.952 1.904 -0.160
ENSG00000120008 E038 135.9027917 0.0004478415 1.163817e-01 3.097802e-01 10 120886689 120886836 148 + 2.104 2.058 -0.153
ENSG00000120008 E039 107.8931365 0.0004176561 3.225376e-01 5.619548e-01 10 120889078 120889184 107 + 2.002 1.973 -0.096
ENSG00000120008 E040 2.9533319 0.0165163861 4.281602e-01 6.495631e-01 10 120889185 120889894 710 + 0.531 0.666 0.600
ENSG00000120008 E041 138.6015290 0.0004255934 5.420233e-01 7.305214e-01 10 120889895 120890009 115 + 2.106 2.095 -0.037
ENSG00000120008 E042 146.6347198 0.0003277428 4.850491e-01 6.906098e-01 10 120890716 120890887 172 + 2.130 2.117 -0.045
ENSG00000120008 E043 1.0233601 0.0157565034 2.681214e-01   10 120899838 120900028 191 + 0.205 0.408 1.375
ENSG00000120008 E044 132.3198952 0.0004718465 9.489339e-01 9.766485e-01 10 120900029 120900137 109 + 2.076 2.087 0.037
ENSG00000120008 E045 93.9599289 0.0004802139 5.049570e-01 7.042835e-01 10 120901036 120901098 63 + 1.921 1.956 0.119
ENSG00000120008 E046 86.7361341 0.0004462722 2.165480e-01 4.493466e-01 10 120902257 120902322 66 + 1.881 1.941 0.200
ENSG00000120008 E047 151.9695317 0.0003638274 5.468708e-01 7.340735e-01 10 120903055 120903232 178 + 2.135 2.163 0.093
ENSG00000120008 E048 0.3807181 0.0356555853 4.928708e-01   10 120904041 120904046 6 + 0.079 0.182 1.378
ENSG00000120008 E049 71.7404073 0.0010031940 6.599900e-01 8.099905e-01 10 120904047 120904064 18 + 1.826 1.815 -0.038
ENSG00000120008 E050 101.7556517 0.0017464924 5.833121e-01 7.591837e-01 10 120904065 120904142 78 + 1.962 1.995 0.112
ENSG00000120008 E051 0.0000000       10 120904143 120904150 8 +      
ENSG00000120008 E052 52.0707176 0.0041078289 1.246776e-01 3.232293e-01 10 120904646 120904649 4 + 1.655 1.755 0.342
ENSG00000120008 E053 138.1363184 0.0002952567 2.902672e-04 3.631238e-03 10 120904650 120904811 162 + 2.060 2.185 0.418
ENSG00000120008 E054 53.3280604 0.0043293766 4.459076e-01 6.626881e-01 10 120905319 120905320 2 + 1.674 1.725 0.171
ENSG00000120008 E055 108.6452403 0.0008447558 6.168496e-06 1.380387e-04 10 120905321 120905416 96 + 1.935 2.112 0.593
ENSG00000120008 E056 19.6674433 0.1930946542 7.276865e-01 8.528496e-01 10 120905417 120905656 240 + 1.276 1.263 -0.042
ENSG00000120008 E057 133.9823886 0.0054276765 1.291194e-02 7.010052e-02 10 120905876 120906021 146 + 2.044 2.172 0.426
ENSG00000120008 E058 95.2062347 0.0536902594 4.862529e-01 6.914253e-01 10 120906022 120906775 754 + 1.910 2.004 0.313
ENSG00000120008 E059 111.3512603 0.0003476767 4.689215e-04 5.391947e-03 10 120906776 120906855 80 + 1.964 2.098 0.447
ENSG00000120008 E060 32.2944025 0.0290763864 1.843931e-01 4.097054e-01 10 120907295 120908555 1261 + 1.432 1.567 0.463
ENSG00000120008 E061 401.6556739 0.0031396699 9.462330e-08 3.531512e-06 10 120908556 120909524 969 + 2.503 2.674 0.568