ENSG00000119912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265986 ENSG00000119912 HEK293_OSMI2_6hA HEK293_TMG_6hB IDE protein_coding protein_coding 15.02007 6.241666 24.46313 1.84397 1.391838 1.968886 2.1138494 1.8815174 2.896277 0.7741511 0.1159387 0.6196281 0.15401250 0.28576667 0.11973333 -0.16603333 0.04101724 0.04101724 FALSE TRUE
ENST00000371581 ENSG00000119912 HEK293_OSMI2_6hA HEK293_TMG_6hB IDE protein_coding protein_coding 15.02007 6.241666 24.46313 1.84397 1.391838 1.968886 0.6180722 0.2503799 0.000000 0.2503799 0.0000000 -4.7025460 0.11170000 0.03290000 0.00000000 -0.03290000 0.70074052 0.04101724 FALSE TRUE
ENST00000677079 ENSG00000119912 HEK293_OSMI2_6hA HEK293_TMG_6hB IDE protein_coding protein_coding 15.02007 6.241666 24.46313 1.84397 1.391838 1.968886 1.0182364 0.1966098 2.335784 0.1966098 0.7009277 3.5050901 0.04518750 0.02306667 0.09813333 0.07506667 0.40514779 0.04101724 FALSE TRUE
ENST00000677096 ENSG00000119912 HEK293_OSMI2_6hA HEK293_TMG_6hB IDE protein_coding nonsense_mediated_decay 15.02007 6.241666 24.46313 1.84397 1.391838 1.968886 1.3481443 0.5367016 1.841150 0.2663045 0.6359054 1.7595961 0.09250000 0.08893333 0.07686667 -0.01206667 0.96913247 0.04101724 FALSE TRUE
ENST00000679174 ENSG00000119912 HEK293_OSMI2_6hA HEK293_TMG_6hB IDE protein_coding nonsense_mediated_decay 15.02007 6.241666 24.46313 1.84397 1.391838 1.968886 1.8974084 0.5935272 3.063049 0.5935272 0.7637699 2.3481799 0.12102917 0.07796667 0.12256667 0.04460000 0.49532001 0.04101724 FALSE TRUE
ENST00000679222 ENSG00000119912 HEK293_OSMI2_6hA HEK293_TMG_6hB IDE protein_coding nonsense_mediated_decay 15.02007 6.241666 24.46313 1.84397 1.391838 1.968886 1.0574929 0.5265706 2.001407 0.5265706 0.5116590 1.9063651 0.05292083 0.06180000 0.08226667 0.02046667 0.60345965 0.04101724 FALSE TRUE
MSTRG.4394.28 ENSG00000119912 HEK293_OSMI2_6hA HEK293_TMG_6hB IDE protein_coding   15.02007 6.241666 24.46313 1.84397 1.391838 1.968886 4.0447685 1.1954186 7.610252 0.4269876 0.7883894 2.6603045 0.20749167 0.19420000 0.30936667 0.11516667 0.27336416 0.04101724 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119912 E001 15.8959889 0.0020859177 5.295162e-04 5.944998e-03 10 92451684 92451935 252 - 1.080 1.380 1.062
ENSG00000119912 E002 5.0258706 0.0055265429 6.689185e-01 8.155117e-01 10 92451936 92451936 1 - 0.714 0.773 0.239
ENSG00000119912 E003 21.6875634 0.0015943948 4.791310e-04 5.487050e-03 10 92451937 92452255 319 - 1.219 1.485 0.924
ENSG00000119912 E004 9.4116675 0.0033743036 3.927432e-03 2.874244e-02 10 92452256 92452258 3 - 0.873 1.182 1.139
ENSG00000119912 E005 9.5130856 0.0031339134 6.436144e-04 6.950307e-03 10 92452259 92452265 7 - 0.850 1.213 1.334
ENSG00000119912 E006 9.7868781 0.0030426399 4.198684e-05 7.171207e-04 10 92452266 92452269 4 - 0.826 1.255 1.575
ENSG00000119912 E007 10.3832123 0.0029586565 7.233366e-05 1.140786e-03 10 92452270 92452271 2 - 0.861 1.268 1.483
ENSG00000119912 E008 41.8158916 0.0011452296 2.252332e-06 5.793665e-05 10 92452272 92452375 104 - 1.494 1.759 0.903
ENSG00000119912 E009 32.7378650 0.0012450116 1.514526e-06 4.081912e-05 10 92452376 92452387 12 - 1.376 1.677 1.031
ENSG00000119912 E010 299.6449082 0.0001771607 3.756637e-05 6.539190e-04 10 92452388 92453514 1127 - 2.400 2.487 0.290
ENSG00000119912 E011 179.9299726 0.0004647805 9.445820e-01 9.746424e-01 10 92453515 92454112 598 - 2.205 2.199 -0.019
ENSG00000119912 E012 46.3329835 0.0033251675 2.870641e-01 5.278349e-01 10 92454113 92454268 156 - 1.602 1.667 0.220
ENSG00000119912 E013 131.1971789 0.0003156232 2.908321e-04 3.636697e-03 10 92454269 92454539 271 - 2.035 2.153 0.394
ENSG00000119912 E014 3.0411460 0.1913730735 2.198649e-01 4.533582e-01 10 92454540 92455575 1036 - 0.487 0.734 1.094
ENSG00000119912 E015 88.9776457 0.0005108486 1.078546e-03 1.051929e-02 10 92455576 92455643 68 - 1.864 1.993 0.435
ENSG00000119912 E016 5.8028222 0.1327658641 3.410736e-01 5.790129e-01 10 92455644 92456358 715 - 0.735 0.885 0.592
ENSG00000119912 E017 95.8522602 0.0005078517 1.489508e-01 3.607797e-01 10 92456359 92456431 73 - 1.917 1.971 0.182
ENSG00000119912 E018 1.3954026 0.0554858923 6.306045e-01 7.908133e-01 10 92456432 92456833 402 - 0.330 0.421 0.527
ENSG00000119912 E019 103.2794108 0.0003973545 3.452712e-01 5.828239e-01 10 92461191 92461252 62 - 1.956 1.989 0.108
ENSG00000119912 E020 0.0000000       10 92462484 92462604 121 -      
ENSG00000119912 E021 192.8607308 0.0003352591 1.361008e-01 3.415147e-01 10 92463731 92464003 273 - 2.226 2.264 0.128
ENSG00000119912 E022 0.1308682 0.0326491905 1.537611e-01   10 92465027 92465104 78 - 0.000 0.189 11.990
ENSG00000119912 E023 152.4271888 0.0020723556 7.752848e-01 8.818997e-01 10 92465676 92465843 168 - 2.133 2.138 0.017
ENSG00000119912 E024 119.9332582 0.0047257506 3.451567e-01 5.827070e-01 10 92468879 92468990 112 - 2.020 2.061 0.136
ENSG00000119912 E025 0.1426347 0.0342450619 1.000000e+00   10 92468991 92469462 472 - 0.075 0.000 -10.715
ENSG00000119912 E026 0.0000000       10 92469463 92469587 125 -      
ENSG00000119912 E027 0.8214337 0.0172671820 1.949953e-01   10 92469588 92469833 246 - 0.290 0.000 -13.140
ENSG00000119912 E028 0.3503582 0.0985268534 4.235659e-01   10 92469834 92470253 420 - 0.076 0.190 1.528
ENSG00000119912 E029 116.4674455 0.0009706296 3.320512e-02 1.365940e-01 10 92470254 92470345 92 - 1.999 2.076 0.259
ENSG00000119912 E030 0.1779838 0.0438406781 1.000000e+00   10 92472979 92474471 1493 - 0.076 0.000 -10.636
ENSG00000119912 E031 0.8981716 0.0172671820 6.285364e-01   10 92474472 92474840 369 - 0.290 0.190 -0.793
ENSG00000119912 E032 110.9051882 0.0027609353 5.003779e-01 7.010190e-01 10 92474841 92474961 121 - 1.991 2.017 0.089
ENSG00000119912 E033 62.8191928 0.0006337105 3.744860e-01 6.077116e-01 10 92475884 92475944 61 - 1.743 1.783 0.137
ENSG00000119912 E034 65.1807888 0.0005917235 7.988164e-01 8.956163e-01 10 92475945 92475994 50 - 1.766 1.775 0.031
ENSG00000119912 E035 0.5008152 0.0454872959 4.600850e-01   10 92475995 92476197 203 - 0.196 0.000 -12.184
ENSG00000119912 E036 3.4516969 0.1127569946 9.931498e-01 9.982520e-01 10 92478645 92478789 145 - 0.620 0.577 -0.189
ENSG00000119912 E037 123.9297275 0.0016611757 9.724687e-01 9.882199e-01 10 92479277 92479421 145 - 2.042 2.037 -0.017
ENSG00000119912 E038 21.4530586 0.1540656861 9.437473e-01 9.742206e-01 10 92479422 92480556 1135 - 1.308 1.264 -0.156
ENSG00000119912 E039 6.7588351 0.0051694606 8.084796e-01 9.012691e-01 10 92480557 92480792 236 - 0.850 0.812 -0.149
ENSG00000119912 E040 7.9261132 0.0470805860 1.868605e-01 4.128595e-01 10 92480793 92480916 124 - 0.849 1.017 0.633
ENSG00000119912 E041 0.3150090 0.0714471324 4.189358e-01   10 92482949 92482967 19 - 0.075 0.190 1.535
ENSG00000119912 E042 0.8217936 0.0261897075 4.745854e-01   10 92482968 92483194 227 - 0.196 0.322 0.950
ENSG00000119912 E043 0.5067846 0.0209467423 7.528844e-01   10 92483195 92483254 60 - 0.140 0.190 0.532
ENSG00000119912 E044 99.5479395 0.0004466388 8.547676e-01 9.274577e-01 10 92483255 92483337 83 - 1.951 1.940 -0.038
ENSG00000119912 E045 110.9513068 0.0003923061 3.696603e-01 6.037452e-01 10 92487196 92487318 123 - 2.005 1.966 -0.132
ENSG00000119912 E046 98.6289756 0.0004787922 1.493465e-02 7.784916e-02 10 92490493 92490595 103 - 1.972 1.865 -0.359
ENSG00000119912 E047 0.0000000       10 92497672 92497761 90 -      
ENSG00000119912 E048 94.6696453 0.0005756854 1.211728e-01 3.177225e-01 10 92504794 92504897 104 - 1.944 1.875 -0.235
ENSG00000119912 E049 81.2331445 0.0005226003 4.782905e-01 6.859661e-01 10 92506442 92506522 81 - 1.871 1.835 -0.122
ENSG00000119912 E050 0.3040503 0.0274424043 7.891937e-01   10 92506523 92507574 1052 - 0.140 0.000 -11.763
ENSG00000119912 E051 80.6247047 0.0031465095 1.294068e-01 3.308580e-01 10 92507575 92507666 92 - 1.881 1.797 -0.284
ENSG00000119912 E052 0.3393995 0.0252919837 7.841554e-01   10 92507667 92508112 446 - 0.140 0.000 -11.785
ENSG00000119912 E053 102.5371084 0.0004575260 1.404606e-04 1.985140e-03 10 92508113 92508205 93 - 1.998 1.832 -0.560
ENSG00000119912 E054 0.6268817 0.1646319140 3.516137e-01   10 92508206 92508516 311 - 0.245 0.000 -12.015
ENSG00000119912 E055 140.8173563 0.0003793193 1.340648e-07 4.842044e-06 10 92508728 92508890 163 - 2.141 1.942 -0.667
ENSG00000119912 E056 95.5637447 0.0004373792 1.470459e-04 2.063101e-03 10 92510050 92510132 83 - 1.970 1.799 -0.576
ENSG00000119912 E057 70.2882172 0.0007325126 2.507412e-02 1.124525e-01 10 92510133 92510162 30 - 1.828 1.711 -0.395
ENSG00000119912 E058 116.4843419 0.0016111399 3.692733e-04 4.430001e-03 10 92514920 92515042 123 - 2.053 1.895 -0.530
ENSG00000119912 E059 114.7368092 0.0010841193 7.199671e-04 7.610720e-03 10 92531748 92531917 170 - 2.046 1.901 -0.485
ENSG00000119912 E060 128.6379136 0.0103619658 2.956391e-03 2.313986e-02 10 92534578 92534785 208 - 2.101 1.923 -0.600
ENSG00000119912 E061 109.9191707 0.0088520933 4.735759e-03 3.319331e-02 10 92537366 92537550 185 - 2.032 1.860 -0.578
ENSG00000119912 E062 0.1426347 0.0342450619 1.000000e+00   10 92541298 92541353 56 - 0.075 0.000 -10.715
ENSG00000119912 E063 0.0000000       10 92554722 92554769 48 -      
ENSG00000119912 E064 0.6356275 0.0397285296 1.000000e+00   10 92554881 92554917 37 - 0.196 0.190 -0.053
ENSG00000119912 E065 1.7202025 0.0218173281 1.691959e-01 3.894997e-01 10 92555372 92556086 715 - 0.331 0.572 1.259
ENSG00000119912 E066 0.3206185 0.0274424043 7.869161e-01   10 92558794 92558922 129 - 0.140 0.000 -11.764
ENSG00000119912 E067 6.9835748 0.0096669624 1.648838e-01 3.838549e-01 10 92559034 92559215 182 - 0.895 0.684 -0.837
ENSG00000119912 E068 9.1952813 0.0214177557 7.422555e-01 8.617942e-01 10 92572913 92573197 285 - 0.954 0.988 0.127
ENSG00000119912 E069 4.1714882 0.0529960304 5.402218e-01 7.291446e-01 10 92573689 92573921 233 - 0.644 0.732 0.368
ENSG00000119912 E070 56.6582840 0.0006424856 2.182140e-02 1.019836e-01 10 92573922 92574096 175 - 1.738 1.607 -0.446