ENSG00000119906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238961 ENSG00000119906 HEK293_OSMI2_6hA HEK293_TMG_6hB SLF2 protein_coding protein_coding 11.02957 7.104966 15.7693 0.3899109 0.166014 1.149105 8.1234175 3.972855367 12.1916581 0.911425552 0.56157628 1.615202 0.68602500 0.5490000000 0.77260000 0.22360000 3.534429e-01 5.605486e-11 FALSE TRUE
ENST00000370269 ENSG00000119906 HEK293_OSMI2_6hA HEK293_TMG_6hB SLF2 protein_coding protein_coding 11.02957 7.104966 15.7693 0.3899109 0.166014 1.149105 0.5957203 0.007580923 1.4835485 0.007580923 0.00356731 6.408589 0.03797917 0.0009666667 0.09410000 0.09313333 5.605486e-11 5.605486e-11 FALSE TRUE
ENST00000609386 ENSG00000119906 HEK293_OSMI2_6hA HEK293_TMG_6hB SLF2 protein_coding protein_coding 11.02957 7.104966 15.7693 0.3899109 0.166014 1.149105 1.6836269 2.781519965 0.9746775 0.474720460 0.31919123 -1.503328 0.22531667 0.3998666667 0.06213333 -0.33773333 4.059365e-03 5.605486e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119906 E001 1.5631088 0.6185205376 5.248783e-01 7.184075e-01 10 100912170 100912962 793 + 0.396 0.204 -1.314
ENSG00000119906 E002 6.6172432 0.1928371261 9.831755e-01 9.933770e-01 10 100912963 100912978 16 + 0.797 0.901 0.402
ENSG00000119906 E003 22.2410235 0.0389208358 4.078947e-02 1.567582e-01 10 100912979 100912995 17 + 1.184 1.557 1.299
ENSG00000119906 E004 67.4836675 0.0442886543 5.910090e-02 2.007499e-01 10 100912996 100913250 255 + 1.662 1.997 1.130
ENSG00000119906 E005 30.5879808 0.2959754227 6.874372e-06 1.515583e-04 10 100913251 100913886 636 + 0.699 1.996 4.613
ENSG00000119906 E006 26.4253354 0.0013078194 2.611711e-06 6.578590e-05 10 100915999 100916042 44 + 1.426 1.146 -0.983
ENSG00000119906 E007 156.6699154 0.0128867599 7.154343e-08 2.751918e-06 10 100916570 100917300 731 + 2.167 1.962 -0.687
ENSG00000119906 E008 43.9156657 0.0111815397 3.052535e-05 5.479816e-04 10 100918384 100918441 58 + 1.622 1.403 -0.752
ENSG00000119906 E009 20.3386509 0.0165811026 1.319002e-03 1.230240e-02 10 100923975 100923977 3 + 1.303 1.066 -0.842
ENSG00000119906 E010 233.2014168 0.0100392941 1.938821e-07 6.707198e-06 10 100923978 100924972 995 + 2.327 2.189 -0.459
ENSG00000119906 E011 0.3393995 0.0262516406 6.040405e-01   10 100925405 100925481 77 + 0.131 0.001 -7.494
ENSG00000119906 E012 67.1456458 0.0008858723 2.433456e-05 4.514987e-04 10 100925949 100926019 71 + 1.784 1.694 -0.306
ENSG00000119906 E013 1.2804824 0.0276833887 5.919330e-01   10 100926020 100926760 741 + 0.274 0.443 1.008
ENSG00000119906 E014 81.1807006 0.0040751108 1.105955e-03 1.071463e-02 10 100929317 100929439 123 + 1.855 1.811 -0.149
ENSG00000119906 E015 62.3383223 0.0271136460 6.164240e-02 2.064916e-01 10 100929830 100929997 168 + 1.738 1.705 -0.112
ENSG00000119906 E016 54.1240994 0.0166244727 1.725724e-02 8.638949e-02 10 100930976 100931078 103 + 1.685 1.616 -0.237
ENSG00000119906 E017 49.2134177 0.0264888168 9.883571e-03 5.763052e-02 10 100937402 100937477 76 + 1.657 1.530 -0.434
ENSG00000119906 E018 72.1816251 0.0181541404 4.618600e-03 3.256866e-02 10 100938595 100938736 142 + 1.815 1.719 -0.325
ENSG00000119906 E019 5.1949794 0.1390757379 6.716544e-01 8.173525e-01 10 100943654 100944025 372 + 0.674 0.877 0.810
ENSG00000119906 E020 64.2604684 0.0104545775 2.377638e-02 1.084130e-01 10 100944026 100944128 103 + 1.750 1.727 -0.078
ENSG00000119906 E021 75.0431962 0.0159240736 6.037058e-01 7.726180e-01 10 100945330 100945506 177 + 1.783 1.886 0.348
ENSG00000119906 E022 66.3015661 0.0310524040 8.126634e-01 9.038127e-01 10 100947039 100947136 98 + 1.725 1.840 0.386
ENSG00000119906 E023 65.9954440 0.0345493373 9.071614e-01 9.557175e-01 10 100947760 100947847 88 + 1.720 1.848 0.434
ENSG00000119906 E024 86.5332221 0.0153424697 7.171903e-01 8.464009e-01 10 100950076 100950207 132 + 1.843 1.948 0.354
ENSG00000119906 E025 76.6062158 0.0104990506 3.287718e-01 5.677591e-01 10 100950676 100950753 78 + 1.802 1.872 0.237
ENSG00000119906 E026 79.8800975 0.0006203921 9.777153e-01 9.906634e-01 10 100956451 100956537 87 + 1.806 1.935 0.432
ENSG00000119906 E027 63.4259162 0.0057058773 4.215989e-01 6.448570e-01 10 100959428 100959496 69 + 1.698 1.866 0.569
ENSG00000119906 E028 1.7210104 0.0121989077 9.197878e-01 9.620949e-01 10 100959497 100959590 94 + 0.382 0.443 0.329
ENSG00000119906 E029 534.2467483 1.8748666508 4.185779e-01 6.425396e-01 10 100961877 100965134 3258 + 2.529 2.920 1.301