ENSG00000119900

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370435 ENSG00000119900 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFRL1 protein_coding protein_coding 6.63955 2.414338 11.42927 0.8306469 0.7347695 2.238333 1.5014217 0.6155000 0.9873543 0.1821321 0.50278327 0.6730962 0.2077500 0.2629667 0.08423333 -0.178733333 5.529035e-01 2.305772e-12 FALSE TRUE
MSTRG.28506.2 ENSG00000119900 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFRL1 protein_coding   6.63955 2.414338 11.42927 0.8306469 0.7347695 2.238333 0.6765400 0.3037729 0.9918204 0.3037729 0.58085736 1.6748312 0.1881333 0.2340000 0.09220000 -0.141800000 8.685102e-01 2.305772e-12 FALSE TRUE
MSTRG.28506.3 ENSG00000119900 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFRL1 protein_coding   6.63955 2.414338 11.42927 0.8306469 0.7347695 2.238333 3.4393504 1.4578685 5.6609057 0.8896188 0.81766032 1.9498564 0.4445625 0.4813000 0.49043333 0.009133333 1.000000e+00 2.305772e-12   FALSE
MSTRG.28506.4 ENSG00000119900 HEK293_OSMI2_6hA HEK293_TMG_6hB OGFRL1 protein_coding   6.63955 2.414338 11.42927 0.8306469 0.7347695 2.238333 0.7323268 0.0000000 3.2903492 0.0000000 0.05666014 8.3664749 0.1188958 0.0000000 0.29003333 0.290033333 2.305772e-12 2.305772e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119900 E001 0.0000000       6 71288811 71288826 16 +      
ENSG00000119900 E002 12.4580140 0.0041838402 1.385453e-04 1.963300e-03 6 71288827 71289170 344 + 0.944 1.318 1.346
ENSG00000119900 E003 0.1614157 0.0343850642 1.000000e+00   6 71289767 71289771 5 + 0.065 0.000 -9.619
ENSG00000119900 E004 0.1614157 0.0343850642 1.000000e+00   6 71289772 71289811 40 + 0.065 0.000 -9.619
ENSG00000119900 E005 0.2027342 0.0397554625 1.025254e-01   6 71290015 71290091 77 + 0.000 0.216 11.713
ENSG00000119900 E006 0.1308682 0.0326491905 1.033041e-01   6 71291318 71291338 21 + 0.000 0.215 11.774
ENSG00000119900 E007 1.7907338 0.0422502849 6.679311e-01 8.148868e-01 6 71291362 71291870 509 + 0.390 0.464 0.397
ENSG00000119900 E008 2.4413156 0.0469887999 9.760584e-01 9.898260e-01 6 71291871 71292020 150 + 0.471 0.466 -0.028
ENSG00000119900 E009 22.1246850 0.0015589447 7.969373e-01 8.945313e-01 6 71293293 71293379 87 + 1.279 1.292 0.043
ENSG00000119900 E010 7.9836107 0.0042958566 7.162188e-01 8.457436e-01 6 71293530 71293532 3 + 0.865 0.905 0.153
ENSG00000119900 E011 35.6845973 0.0010855634 2.113228e-01 4.433541e-01 6 71293533 71293611 79 + 1.461 1.535 0.254
ENSG00000119900 E012 0.0000000       6 71293612 71293612 1 +      
ENSG00000119900 E013 48.5295869 0.0065113854 4.623572e-02 1.706302e-01 6 71296317 71296395 79 + 1.576 1.696 0.410
ENSG00000119900 E014 49.5608244 0.0015951200 3.814783e-02 1.499937e-01 6 71296495 71296561 67 + 1.590 1.701 0.379
ENSG00000119900 E015 60.0655487 0.0008034636 3.727782e-03 2.762417e-02 6 71296672 71296817 146 + 1.666 1.804 0.469
ENSG00000119900 E016 552.4483532 0.0009552203 2.780151e-08 1.180629e-06 6 71301386 71309059 7674 + 2.669 2.591 -0.260