ENSG00000119844

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238856 ENSG00000119844 HEK293_OSMI2_6hA HEK293_TMG_6hB AFTPH protein_coding protein_coding 6.051112 2.746447 9.599939 0.4644856 0.4489535 1.801717 1.53954930 0.1914969 2.9063827 0.1914969 0.5162800 3.855350 0.18216250 0.06536667 0.300333333 0.23496667 0.242844446 0.007594414 FALSE TRUE
ENST00000409183 ENSG00000119844 HEK293_OSMI2_6hA HEK293_TMG_6hB AFTPH protein_coding protein_coding 6.051112 2.746447 9.599939 0.4644856 0.4489535 1.801717 0.48055689 0.9545648 0.1370208 0.1970979 0.1370208 -2.713858 0.12221250 0.34386667 0.013433333 -0.33043333 0.007594414 0.007594414 FALSE TRUE
ENST00000695960 ENSG00000119844 HEK293_OSMI2_6hA HEK293_TMG_6hB AFTPH protein_coding nonsense_mediated_decay 6.051112 2.746447 9.599939 0.4644856 0.4489535 1.801717 0.75664979 0.4296879 1.2859766 0.2469219 0.2242059 1.559488 0.11814583 0.14870000 0.132300000 -0.01640000 1.000000000 0.007594414 TRUE TRUE
MSTRG.18522.10 ENSG00000119844 HEK293_OSMI2_6hA HEK293_TMG_6hB AFTPH protein_coding   6.051112 2.746447 9.599939 0.4644856 0.4489535 1.801717 2.20099912 0.9666562 3.7913629 0.2314457 0.3052407 1.960594 0.33214583 0.34313333 0.399166667 0.05603333 0.868101448 0.007594414 FALSE TRUE
MSTRG.18522.11 ENSG00000119844 HEK293_OSMI2_6hA HEK293_TMG_6hB AFTPH protein_coding   6.051112 2.746447 9.599939 0.4644856 0.4489535 1.801717 0.02122547 0.1180867 0.0308437 0.1180867 0.0308437 -1.648936 0.00865000 0.06326667 0.003533333 -0.05973333 0.889496342 0.007594414 FALSE TRUE
MSTRG.18522.15 ENSG00000119844 HEK293_OSMI2_6hA HEK293_TMG_6hB AFTPH protein_coding   6.051112 2.746447 9.599939 0.4644856 0.4489535 1.801717 0.24074343 0.0000000 0.3572856 0.0000000 0.1202243 5.198830 0.06630833 0.00000000 0.036200000 0.03620000 0.065445794 0.007594414 FALSE TRUE
MSTRG.18522.4 ENSG00000119844 HEK293_OSMI2_6hA HEK293_TMG_6hB AFTPH protein_coding   6.051112 2.746447 9.599939 0.4644856 0.4489535 1.801717 0.21833388 0.0000000 0.0000000 0.0000000 0.0000000 0.000000 0.06818750 0.00000000 0.000000000 0.00000000   0.007594414 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119844 E001 0.0000000       2 64524299 64524304 6 +      
ENSG00000119844 E002 0.1779838 0.047518442 1.000000e+00   2 64524305 64524327 23 + 0.068 0.000 -8.901
ENSG00000119844 E003 0.1779838 0.047518442 1.000000e+00   2 64524328 64524354 27 + 0.068 0.000 -8.898
ENSG00000119844 E004 0.3206185 0.027442404 7.708855e-01   2 64524355 64524374 20 + 0.127 0.000 -9.896
ENSG00000119844 E005 0.3206185 0.027442404 7.708855e-01   2 64524375 64524399 25 + 0.127 0.000 -9.896
ENSG00000119844 E006 0.7389688 0.019387492 8.431789e-01   2 64524400 64524411 12 + 0.225 0.207 -0.157
ENSG00000119844 E007 11.8187473 0.051223818 3.305482e-01 0.5694964012 2 64524412 64524526 115 + 1.052 0.953 -0.363
ENSG00000119844 E008 16.5561762 0.031768967 2.051061e-01 0.4360377574 2 64524527 64524612 86 + 1.190 1.080 -0.393
ENSG00000119844 E009 21.8574002 0.037930472 1.243638e-01 0.3226803255 2 64551443 64551568 126 + 1.305 1.166 -0.491
ENSG00000119844 E010 140.0799810 0.008885578 1.590903e-05 0.0003140439 2 64551569 64552511 943 + 2.099 1.938 -0.540
ENSG00000119844 E011 87.4475718 0.028765030 1.838275e-01 0.4088872306 2 64552512 64552875 364 + 1.872 1.842 -0.099
ENSG00000119844 E012 73.1019217 0.011701965 6.735940e-01 0.8186837816 2 64552876 64553152 277 + 1.780 1.822 0.140
ENSG00000119844 E013 62.3963907 0.001052719 1.962164e-01 0.4248204032 2 64553153 64553409 257 + 1.693 1.818 0.422
ENSG00000119844 E014 57.3007052 0.007619758 6.406935e-01 0.7973770714 2 64567562 64567713 152 + 1.677 1.710 0.109
ENSG00000119844 E015 48.6970085 0.004793402 8.982809e-01 0.9509335802 2 64569092 64569218 127 + 1.604 1.659 0.186
ENSG00000119844 E016 2.1744023 0.010980057 4.394657e-01 0.6582827270 2 64569219 64569622 404 + 0.458 0.347 -0.614
ENSG00000119844 E017 27.8409808 0.001828067 3.735429e-01 0.6069862353 2 64569623 64569679 57 + 1.383 1.373 -0.034
ENSG00000119844 E018 37.9762418 0.001877164 4.881416e-01 0.6927601082 2 64572946 64573068 123 + 1.518 1.531 0.044
ENSG00000119844 E019 0.8377416 0.528958016 3.141399e-01   2 64573069 64573405 337 + 0.127 0.460 2.466
ENSG00000119844 E020 23.3720565 0.008756629 3.368743e-01 0.5752598047 2 64579486 64579546 61 + 1.326 1.297 -0.100
ENSG00000119844 E021 7.8500516 0.003876659 3.175321e-02 0.1325017875 2 64579547 64581099 1553 + 0.929 0.669 -1.032
ENSG00000119844 E022 2.2667284 0.012710266 3.615068e-01 0.5969187546 2 64581100 64581189 90 + 0.484 0.347 -0.744
ENSG00000119844 E023 5.1105619 0.006719412 6.256574e-01 0.7876922833 2 64581190 64581273 84 + 0.692 0.813 0.489
ENSG00000119844 E024 41.6806372 0.059647889 2.098110e-01 0.4416357972 2 64585422 64585545 124 + 1.507 1.689 0.621
ENSG00000119844 E025 11.9850439 0.395249138 3.130571e-01 0.5533452162 2 64591885 64591887 3 + 0.982 1.205 0.804
ENSG00000119844 E026 125.7356912 1.414683099 3.219080e-01 0.5613683258 2 64591888 64593005 1118 + 1.908 2.283 1.258