ENSG00000119787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378954 ENSG00000119787 HEK293_OSMI2_6hA HEK293_TMG_6hB ATL2 protein_coding protein_coding 47.32635 8.313406 89.99128 0.8945908 1.178115 3.4347 12.1074271 4.2820569 20.815810 0.8562433 0.7694437 2.278631 0.39206667 0.50646667 0.2311667 -0.27530000 1.154327e-02 1.578083e-27 FALSE TRUE
ENST00000406122 ENSG00000119787 HEK293_OSMI2_6hA HEK293_TMG_6hB ATL2 protein_coding protein_coding 47.32635 8.313406 89.99128 0.8945908 1.178115 3.4347 4.4896660 0.9585779 9.800741 0.1884517 0.5029658 3.340422 0.11677917 0.11963333 0.1089667 -0.01066667 9.994408e-01 1.578083e-27 FALSE TRUE
ENST00000472097 ENSG00000119787 HEK293_OSMI2_6hA HEK293_TMG_6hB ATL2 protein_coding retained_intron 47.32635 8.313406 89.99128 0.8945908 1.178115 3.4347 10.2162118 0.0000000 22.384193 0.0000000 0.4517666 11.128909 0.11760417 0.00000000 0.2488000 0.24880000 1.578083e-27 1.578083e-27 FALSE FALSE
ENST00000474535 ENSG00000119787 HEK293_OSMI2_6hA HEK293_TMG_6hB ATL2 protein_coding retained_intron 47.32635 8.313406 89.99128 0.8945908 1.178115 3.4347 0.8940394 0.5509124 1.629584 0.3027915 0.7500326 1.547483 0.02738750 0.07166667 0.0179000 -0.05376667 8.156263e-01 1.578083e-27 FALSE TRUE
ENST00000477642 ENSG00000119787 HEK293_OSMI2_6hA HEK293_TMG_6hB ATL2 protein_coding retained_intron 47.32635 8.313406 89.99128 0.8945908 1.178115 3.4347 6.6024197 1.4167369 12.589985 0.1236360 0.3413930 3.142631 0.13798750 0.17246667 0.1400333 -0.03243333 6.511102e-01 1.578083e-27 FALSE TRUE
ENST00000651368 ENSG00000119787 HEK293_OSMI2_6hA HEK293_TMG_6hB ATL2 protein_coding protein_coding 47.32635 8.313406 89.99128 0.8945908 1.178115 3.4347 4.3243113 0.0000000 10.789675 0.0000000 1.0955724 10.076772 0.05019583 0.00000000 0.1199000 0.11990000 1.214594e-13 1.578083e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119787 E001 41.2345272 0.0027526272 2.316065e-09 1.259434e-07 2 38293954 38294359 406 - 1.390 1.793 1.375
ENSG00000119787 E002 193.4417024 0.0002370491 2.778091e-13 3.170590e-11 2 38294360 38295153 794 - 2.088 2.325 0.792
ENSG00000119787 E003 281.2620406 0.0002474923 1.734201e-04 2.373909e-03 2 38295154 38295430 277 - 2.272 2.382 0.366
ENSG00000119787 E004 251.7687766 0.0027470153 1.859239e-02 9.103695e-02 2 38295431 38295608 178 - 2.227 2.319 0.306
ENSG00000119787 E005 253.3374578 0.0002277007 4.593544e-03 3.244013e-02 2 38295609 38295900 292 - 2.231 2.319 0.295
ENSG00000119787 E006 81.6580171 0.0004546248 3.837555e-01 6.153676e-01 2 38295901 38295902 2 - 1.750 1.800 0.169
ENSG00000119787 E007 84.4135568 0.0004458021 4.859499e-01 6.912147e-01 2 38295903 38295907 5 - 1.765 1.805 0.135
ENSG00000119787 E008 289.2846972 0.0003008210 5.918041e-01 7.649772e-01 2 38295908 38296113 206 - 2.303 2.289 -0.046
ENSG00000119787 E009 57.9374159 0.0017438951 4.033261e-01 6.309681e-01 2 38296114 38296356 243 - 1.621 1.567 -0.186
ENSG00000119787 E010 32.9287929 0.0011267511 9.970726e-01 1.000000e+00 2 38296357 38296407 51 - 1.375 1.378 0.010
ENSG00000119787 E011 43.4224179 0.0009117298 7.391307e-01 8.598474e-01 2 38296408 38296482 75 - 1.489 1.516 0.094
ENSG00000119787 E012 56.9222284 0.0007443611 5.931093e-01 7.657376e-01 2 38296483 38296590 108 - 1.601 1.638 0.127
ENSG00000119787 E013 34.0780468 0.0041215369 3.610011e-01 5.964675e-01 2 38296686 38296700 15 - 1.399 1.314 -0.295
ENSG00000119787 E014 52.7746265 0.0056093339 6.230612e-02 2.079520e-01 2 38297931 38298143 213 - 1.589 1.433 -0.533
ENSG00000119787 E015 201.7309415 0.0003893950 5.492743e-01 7.358103e-01 2 38298144 38298217 74 - 2.147 2.127 -0.065
ENSG00000119787 E016 447.8532374 0.0001625794 4.768272e-01 6.848808e-01 2 38298218 38298575 358 - 2.489 2.508 0.064
ENSG00000119787 E017 157.1214597 0.0021503653 9.780975e-01 9.908069e-01 2 38299256 38299327 72 - 2.039 2.039 -0.001
ENSG00000119787 E018 140.1086741 0.0045011358 9.978464e-01 1.000000e+00 2 38300272 38300328 57 - 1.990 1.988 -0.008
ENSG00000119787 E019 1.8370416 0.0322507023 9.168861e-02 2.668375e-01 2 38300329 38300433 105 - 0.305 0.629 1.680
ENSG00000119787 E020 125.9862751 0.0022791797 6.873906e-01 8.274300e-01 2 38309379 38309430 52 - 1.946 1.926 -0.070
ENSG00000119787 E021 158.5773947 0.0002966620 4.717264e-01 6.813323e-01 2 38309431 38309506 76 - 2.046 2.020 -0.089
ENSG00000119787 E022 205.1257014 0.0003420938 5.683182e-01 7.490445e-01 2 38310309 38310447 139 - 2.156 2.138 -0.059
ENSG00000119787 E023 203.7888388 0.0012373172 3.111910e-01 5.515911e-01 2 38313151 38313243 93 - 2.154 2.117 -0.127
ENSG00000119787 E024 127.2243290 0.0003200317 1.129831e-01 3.041376e-01 2 38314608 38314608 1 - 1.957 1.886 -0.239
ENSG00000119787 E025 174.0418931 0.0003295612 1.112078e-01 3.009712e-01 2 38314609 38314654 46 - 2.091 2.030 -0.204
ENSG00000119787 E026 110.9076997 0.0004326986 2.458212e-02 1.109289e-01 2 38314655 38314664 10 - 1.901 1.788 -0.381
ENSG00000119787 E027 139.9466082 0.0003334434 3.873017e-02 1.514419e-01 2 38315284 38315334 51 - 1.999 1.909 -0.304
ENSG00000119787 E028 5.2774966 0.3356491996 2.667331e-02 1.172779e-01 2 38318326 38318534 209 - 0.506 1.146 2.561
ENSG00000119787 E029 184.2946614 0.0002543666 1.503493e-03 1.364361e-02 2 38318535 38318639 105 - 2.123 1.999 -0.416
ENSG00000119787 E030 2.3360217 0.0771644762 1.100712e-01 2.991297e-01 2 38318835 38318884 50 - 0.448 0.000 -12.503
ENSG00000119787 E031 149.7908157 0.0002826985 1.912213e-04 2.577332e-03 2 38318885 38318936 52 - 2.038 1.872 -0.559
ENSG00000119787 E032 201.2363878 0.0002992032 4.384948e-03 3.129107e-02 2 38318937 38319019 83 - 2.160 2.055 -0.351
ENSG00000119787 E033 126.2794247 0.0003836974 7.397086e-02 2.327209e-01 2 38343268 38343293 26 - 1.958 1.877 -0.273
ENSG00000119787 E034 93.7782774 0.0005986020 5.932016e-01 7.658042e-01 2 38343294 38343296 3 - 1.825 1.799 -0.085
ENSG00000119787 E035 249.8518973 0.0003724714 1.112509e-02 6.289269e-02 2 38343297 38343512 216 - 2.251 2.167 -0.279
ENSG00000119787 E036 3.5847238 0.0241644029 2.631634e-01 5.023797e-01 2 38354067 38354177 111 - 0.501 0.706 0.913
ENSG00000119787 E037 0.1426347 0.0320928031 8.762886e-01   2 38358443 38358688 246 - 0.052 0.000 -9.000
ENSG00000119787 E038 0.0000000       2 38359517 38359604 88 -      
ENSG00000119787 E039 0.3032425 0.0274424043 7.739519e-03   2 38376116 38376594 479 - 0.000 0.420 13.135
ENSG00000119787 E040 93.8091503 0.0016956378 4.967603e-01 6.987335e-01 2 38377143 38377285 143 - 1.824 1.788 -0.122