ENSG00000119760

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337768 ENSG00000119760 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT7L protein_coding protein_coding 26.50675 26.52455 27.29542 3.660873 1.167019 0.04131526 2.828776 1.614311 3.740755 0.09475112 0.2778768 1.20735311 0.10647083 0.06246667 0.13670000 0.074233333 0.00135330 0.0013533 FALSE TRUE
ENST00000405491 ENSG00000119760 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT7L protein_coding protein_coding 26.50675 26.52455 27.29542 3.660873 1.167019 0.04131526 3.789841 4.957314 3.305540 1.47200535 0.2844304 -0.58322219 0.14227083 0.17906667 0.12063333 -0.058433333 0.67045459 0.0013533 FALSE TRUE
ENST00000406540 ENSG00000119760 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT7L protein_coding protein_coding 26.50675 26.52455 27.29542 3.660873 1.167019 0.04131526 6.518827 5.203771 10.356584 1.13762196 1.1819444 0.99154142 0.24919167 0.21383333 0.37883333 0.165000000 0.44042915 0.0013533 FALSE TRUE
MSTRG.18135.1 ENSG00000119760 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT7L protein_coding   26.50675 26.52455 27.29542 3.660873 1.167019 0.04131526 2.256105 1.415594 1.558067 0.44283044 0.3785496 0.13742395 0.08524167 0.05570000 0.05620000 0.000500000 0.99954830 0.0013533 TRUE TRUE
MSTRG.18135.11 ENSG00000119760 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT7L protein_coding   26.50675 26.52455 27.29542 3.660873 1.167019 0.04131526 2.059848 2.448619 1.371921 1.11302177 0.5948467 -0.83117264 0.07647917 0.08343333 0.05223333 -0.031200000 0.86403651 0.0013533 FALSE TRUE
MSTRG.18135.4 ENSG00000119760 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT7L protein_coding   26.50675 26.52455 27.29542 3.660873 1.167019 0.04131526 4.653649 6.609428 2.234192 1.79398991 0.4321923 -1.56051047 0.17610000 0.24280000 0.08296667 -0.159833333 0.05444693 0.0013533 TRUE TRUE
MSTRG.18135.5 ENSG00000119760 HEK293_OSMI2_6hA HEK293_TMG_6hB SUPT7L protein_coding   26.50675 26.52455 27.29542 3.660873 1.167019 0.04131526 2.946162 4.157209 4.238926 0.43054821 0.4080561 0.02801664 0.11051250 0.15890000 0.15523333 -0.003666667 0.99567526 0.0013533 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119760 E001 1.035197 0.033570956 1.644089e-01   2 27642618 27642629 12 - 0.427 0.209 -1.438
ENSG00000119760 E002 1.792139 0.011519389 3.305399e-01 5.694878e-01 2 27642630 27642684 55 - 0.525 0.406 -0.607
ENSG00000119760 E003 1.690823 0.011225293 9.232978e-01 9.639509e-01 2 27642685 27642722 38 - 0.428 0.456 0.143
ENSG00000119760 E004 7.500918 0.072848959 2.066380e-01 4.376816e-01 2 27642723 27642892 170 - 0.990 0.871 -0.447
ENSG00000119760 E005 9.042809 0.054247609 8.623206e-01 9.315937e-01 2 27646866 27646993 128 - 0.973 1.041 0.248
ENSG00000119760 E006 4.432964 0.018037707 3.743676e-01 6.076697e-01 2 27650809 27650811 3 - 0.781 0.701 -0.323
ENSG00000119760 E007 136.603574 0.022187434 3.994711e-07 1.271353e-05 2 27650812 27653034 2223 - 2.269 1.975 -0.985
ENSG00000119760 E008 14.307706 0.049655952 1.656821e-02 8.386216e-02 2 27653035 27653051 17 - 1.291 1.053 -0.848
ENSG00000119760 E009 14.016798 0.042950206 2.209580e-03 1.846205e-02 2 27653052 27653062 11 - 1.313 0.998 -1.127
ENSG00000119760 E010 11.543147 0.078730770 4.952658e-02 1.784795e-01 2 27653063 27653063 1 - 1.202 0.981 -0.800
ENSG00000119760 E011 12.567315 0.078985476 3.167343e-02 1.322566e-01 2 27653064 27653069 6 - 1.246 0.996 -0.901
ENSG00000119760 E012 211.231835 0.044128116 2.532952e-01 4.915115e-01 2 27653070 27653433 364 - 2.330 2.323 -0.025
ENSG00000119760 E013 360.564356 0.053475541 5.259072e-01 7.191897e-01 2 27653434 27653747 314 - 2.534 2.578 0.145
ENSG00000119760 E014 310.179627 0.063035934 4.667956e-01 6.778645e-01 2 27655365 27655602 238 - 2.478 2.505 0.089
ENSG00000119760 E015 166.702984 0.046829223 3.921522e-01 6.221416e-01 2 27657345 27657389 45 - 2.216 2.231 0.050
ENSG00000119760 E016 360.086242 0.005642986 1.760612e-01 3.985502e-01 2 27657390 27657669 280 - 2.480 2.619 0.460
ENSG00000119760 E017 267.752470 1.288126036 4.550658e-01 6.695429e-01 2 27660984 27661155 172 - 2.313 2.511 0.660
ENSG00000119760 E018 157.153079 1.094687914 4.600409e-01 6.731826e-01 2 27661156 27661198 43 - 2.102 2.270 0.564
ENSG00000119760 E019 256.762211 1.283865926 4.752751e-01 6.837205e-01 2 27661199 27661388 190 - 2.309 2.485 0.590
ENSG00000119760 E020 69.840679 0.665032095 6.542827e-01 8.062642e-01 2 27661389 27661601 213 - 1.861 1.839 -0.074
ENSG00000119760 E021 106.964553 1.148802811 8.131969e-01 9.041558e-01 2 27661602 27662178 577 - 2.078 1.988 -0.304
ENSG00000119760 E022 161.554174 1.089333859 4.278903e-01 6.494041e-01 2 27662179 27662281 103 - 2.096 2.293 0.657
ENSG00000119760 E023 15.999512 0.104311878 5.559728e-01 7.405003e-01 2 27663324 27663328 5 - 1.184 1.275 0.322
ENSG00000119760 E024 196.178274 1.156600318 4.201635e-01 6.437808e-01 2 27663329 27663514 186 - 2.167 2.384 0.725
ENSG00000119760 E025 98.796576 0.641519827 2.901976e-01 5.307987e-01 2 27663515 27663840 326 - 1.852 2.098 0.828