ENSG00000119707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261973 ENSG00000119707 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM25 protein_coding protein_coding 46.0482 23.79105 69.97251 1.826158 3.179763 1.555969 20.346027 12.5270943 28.424947 1.99727693 0.1601128 1.181462 0.4740750 0.51970000 0.4078667 -0.11183333 5.099848e-01 1.968459e-05 FALSE TRUE
ENST00000525321 ENSG00000119707 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM25 protein_coding protein_coding 46.0482 23.79105 69.97251 1.826158 3.179763 1.555969 2.251211 0.5505261 5.653089 0.07721503 0.2072109 3.336736 0.0346750 0.02343333 0.0810000 0.05756667 1.968459e-05 1.968459e-05 FALSE TRUE
ENST00000531500 ENSG00000119707 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM25 protein_coding protein_coding 46.0482 23.79105 69.97251 1.826158 3.179763 1.555969 6.861814 1.3505038 10.813490 0.69569360 1.1408963 2.991953 0.1091125 0.05773333 0.1541000 0.09636667 6.549309e-01 1.968459e-05 FALSE FALSE
ENST00000532483 ENSG00000119707 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM25 protein_coding processed_transcript 46.0482 23.79105 69.97251 1.826158 3.179763 1.555969 14.158026 8.0135978 21.546356 0.38186470 2.5479105 1.425792 0.3225792 0.33936667 0.3059000 -0.03346667 8.534944e-01 1.968459e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119707 E001 0.1779838 3.494829e-02 1.000000e+00   14 73057585 73057632 48 + 0.088 0.000 -9.802
ENSG00000119707 E002 0.1779838 3.494829e-02 1.000000e+00   14 73057633 73057838 206 + 0.088 0.000 -9.790
ENSG00000119707 E003 0.0000000       14 73057839 73058140 302 +      
ENSG00000119707 E004 2.3954875 2.661412e-01 5.753744e-01 7.539143e-01 14 73058141 73058531 391 + 0.478 0.611 0.622
ENSG00000119707 E005 2.3954875 2.661412e-01 5.753744e-01 7.539143e-01 14 73058532 73058532 1 + 0.478 0.611 0.622
ENSG00000119707 E006 2.3954875 2.661412e-01 5.753744e-01 7.539143e-01 14 73058533 73058533 1 + 0.478 0.611 0.622
ENSG00000119707 E007 6.0648257 3.313030e-01 8.278507e-01 9.125357e-01 14 73058534 73058541 8 + 0.836 0.830 -0.027
ENSG00000119707 E008 6.5412504 3.443062e-01 7.929122e-01 8.921136e-01 14 73058542 73058543 2 + 0.863 0.859 -0.015
ENSG00000119707 E009 14.6864870 5.449197e-01 6.618123e-01 8.110009e-01 14 73058544 73058546 3 + 1.175 1.168 -0.028
ENSG00000119707 E010 17.8256953 6.206900e-01 6.857032e-01 8.263145e-01 14 73058547 73058548 2 + 1.260 1.236 -0.084
ENSG00000119707 E011 103.3154261 1.404311e+00 5.829617e-01 7.589962e-01 14 73058549 73058667 119 + 1.957 2.057 0.334
ENSG00000119707 E012 104.5713861 1.399227e+00 5.646080e-01 7.464998e-01 14 73058668 73058705 38 + 1.957 2.071 0.381
ENSG00000119707 E013 0.3040503 2.744240e-02 4.826611e-01   14 73058706 73058811 106 + 0.161 0.000 -10.787
ENSG00000119707 E014 6.3141557 2.444163e-01 8.399898e-02 2.527996e-01 14 73064972 73065093 122 + 0.705 1.044 1.305
ENSG00000119707 E015 0.9452873 1.634427e-02 5.945577e-02   14 73069853 73069920 68 + 0.371 0.000 -12.373
ENSG00000119707 E016 78.2953210 4.342911e-01 4.134850e-01 6.386519e-01 14 73071627 73071636 10 + 1.833 1.946 0.378
ENSG00000119707 E017 205.2892880 3.132243e-02 8.426501e-01 9.209181e-01 14 73071637 73071747 111 + 2.288 2.295 0.023
ENSG00000119707 E018 189.3757924 9.210267e-03 2.051422e-01 4.360812e-01 14 73076319 73076368 50 + 2.278 2.210 -0.226
ENSG00000119707 E019 326.6921215 6.490012e-04 3.966726e-02 1.538756e-01 14 73077369 73077536 168 + 2.508 2.460 -0.157
ENSG00000119707 E020 202.6889437 2.958552e-04 1.424460e-02 7.531558e-02 14 73083494 73083551 58 + 2.306 2.240 -0.220
ENSG00000119707 E021 373.5875865 1.165807e-03 1.331335e-07 4.810454e-06 14 73088001 73088161 161 + 2.588 2.453 -0.449
ENSG00000119707 E022 3.2476073 1.468521e-02 3.893703e-01 6.199664e-01 14 73088370 73088474 105 + 0.662 0.520 -0.639
ENSG00000119707 E023 336.0204616 2.438231e-04 1.903561e-10 1.271400e-08 14 73096915 73097035 121 + 2.544 2.405 -0.465
ENSG00000119707 E024 256.2891580 6.150887e-04 2.670358e-05 4.879366e-04 14 73097036 73097100 65 + 2.419 2.308 -0.371
ENSG00000119707 E025 263.3822624 2.665563e-04 2.413087e-05 4.483072e-04 14 73099380 73099433 54 + 2.429 2.326 -0.342
ENSG00000119707 E026 305.8594358 2.619512e-04 3.562949e-07 1.148360e-05 14 73099667 73099750 84 + 2.496 2.380 -0.387
ENSG00000119707 E027 66.3476421 9.031436e-02 2.275173e-03 1.889372e-02 14 73099751 73100300 550 + 1.908 1.454 -1.542
ENSG00000119707 E028 31.7829247 3.150680e-02 8.311252e-03 5.076033e-02 14 73100301 73100362 62 + 1.568 1.268 -1.035
ENSG00000119707 E029 60.7147250 5.539894e-02 1.345396e-02 7.220910e-02 14 73100363 73100713 351 + 1.844 1.537 -1.041
ENSG00000119707 E030 277.8644125 8.727768e-02 2.798377e-02 1.212195e-01 14 73100714 73103191 2478 + 2.495 2.213 -0.940
ENSG00000119707 E031 594.7682936 4.856298e-03 4.850969e-01 6.906489e-01 14 73103192 73103478 287 + 2.758 2.731 -0.091
ENSG00000119707 E032 163.6633865 6.965539e-04 9.611928e-01 9.825952e-01 14 73105859 73105860 2 + 2.190 2.193 0.009
ENSG00000119707 E033 549.9225330 9.801720e-04 4.699131e-03 3.299923e-02 14 73105861 73106081 221 + 2.695 2.756 0.202
ENSG00000119707 E034 385.6449851 1.631287e-04 3.498045e-06 8.481560e-05 14 73106196 73106279 84 + 2.531 2.620 0.298
ENSG00000119707 E035 233.0126525 2.160085e-04 6.168632e-06 1.380387e-04 14 73106280 73106285 6 + 2.304 2.415 0.371
ENSG00000119707 E036 1.4468720 1.198378e-02 6.479076e-03 4.209112e-02 14 73107302 73107825 524 + 0.161 0.627 2.846
ENSG00000119707 E037 364.7066166 1.699812e-04 8.387243e-04 8.598012e-03 14 73107826 73107899 74 + 2.514 2.581 0.222
ENSG00000119707 E038 1.7576293 6.766125e-02 1.072859e-01 2.944916e-01 14 73109131 73109341 211 + 0.279 0.582 1.645
ENSG00000119707 E039 422.0342120 1.649244e-04 1.312492e-01 3.337748e-01 14 73109342 73109492 151 + 2.591 2.620 0.096
ENSG00000119707 E040 650.4409428 9.580277e-05 1.243639e-03 1.174696e-02 14 73110831 73111155 325 + 2.772 2.820 0.159
ENSG00000119707 E041 17.8980638 9.676147e-02 6.971808e-01 8.336950e-01 14 73111156 73111308 153 + 1.214 1.308 0.332
ENSG00000119707 E042 15.1379372 6.696025e-02 8.899888e-01 9.466757e-01 14 73111309 73111382 74 + 1.168 1.199 0.111
ENSG00000119707 E043 23.6854697 7.436786e-02 9.729491e-01 9.884490e-01 14 73111383 73111527 145 + 1.359 1.377 0.061
ENSG00000119707 E044 665.0085007 1.102265e-03 3.740465e-01 6.074140e-01 14 73111528 73111802 275 + 2.791 2.810 0.063
ENSG00000119707 E045 326.9937723 4.417431e-04 2.256506e-02 1.044530e-01 14 73112152 73112250 99 + 2.472 2.524 0.173
ENSG00000119707 E046 279.8645043 1.503370e-03 1.852407e-04 2.509224e-03 14 73114286 73114333 48 + 2.383 2.490 0.356
ENSG00000119707 E047 1238.0497909 7.364652e-03 7.177265e-02 2.283587e-01 14 73119713 73123899 4187 + 3.042 3.114 0.240