ENSG00000119638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553823 ENSG00000119638 HEK293_OSMI2_6hA HEK293_TMG_6hB NEK9 protein_coding protein_coding 46.46265 54.07468 38.05798 1.95849 0.3677852 -0.5066421 2.621627 1.268566 3.627235 0.4239363 0.7418637 1.5083151 0.05823333 0.02350000 0.09560000 0.07210000 0.057683479 6.645151e-15 FALSE TRUE
ENST00000553945 ENSG00000119638 HEK293_OSMI2_6hA HEK293_TMG_6hB NEK9 protein_coding nonsense_mediated_decay 46.46265 54.07468 38.05798 1.95849 0.3677852 -0.5066421 6.050682 8.484011 2.863417 0.4257591 1.4567262 -1.5636786 0.12804167 0.15756667 0.07480000 -0.08276667 0.773367887 6.645151e-15 TRUE TRUE
ENST00000555405 ENSG00000119638 HEK293_OSMI2_6hA HEK293_TMG_6hB NEK9 protein_coding retained_intron 46.46265 54.07468 38.05798 1.95849 0.3677852 -0.5066421 7.247141 11.242900 1.744764 1.3490958 0.6445497 -2.6809481 0.15419583 0.20773333 0.04610000 -0.16163333 0.006883868 6.645151e-15 FALSE TRUE
ENST00000557026 ENSG00000119638 HEK293_OSMI2_6hA HEK293_TMG_6hB NEK9 protein_coding retained_intron 46.46265 54.07468 38.05798 1.95849 0.3677852 -0.5066421 3.210897 2.770465 3.605035 1.8247948 0.1177942 0.3786837 0.06891667 0.05096667 0.09476667 0.04380000 0.764277023 6.645151e-15 FALSE TRUE
ENST00000678749 ENSG00000119638 HEK293_OSMI2_6hA HEK293_TMG_6hB NEK9 protein_coding protein_coding 46.46265 54.07468 38.05798 1.95849 0.3677852 -0.5066421 17.160403 19.486050 16.266676 1.9321184 0.6150289 -0.2603758 0.37115833 0.35940000 0.42743333 0.06803333 0.584110341 6.645151e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119638 E001 3.7219548 0.0069501663 7.476592e-01 0.8653107105 14 75079353 75081410 2058 - 0.683 0.657 -0.110
ENSG00000119638 E002 27.8452209 0.0218085495 5.684592e-01 0.7491343633 14 75081411 75082118 708 - 1.466 1.438 -0.095
ENSG00000119638 E003 6.3767215 0.0339711765 8.590352e-01 0.9298443871 14 75082119 75082120 2 - 0.874 0.873 -0.004
ENSG00000119638 E004 11.5379633 0.0118337322 5.049626e-01 0.7042835135 14 75082121 75082128 8 - 1.039 1.138 0.359
ENSG00000119638 E005 53.7777654 0.0062399103 1.052803e-01 0.2911701283 14 75082129 75082171 43 - 1.646 1.778 0.448
ENSG00000119638 E006 735.6910976 0.0085110031 5.320204e-03 0.0362965238 14 75082172 75082789 618 - 2.757 2.919 0.537
ENSG00000119638 E007 1557.1180093 0.0045704614 1.124404e-02 0.0633773551 14 75082790 75084086 1297 - 3.113 3.228 0.383
ENSG00000119638 E008 364.6930017 0.0006168078 1.786318e-02 0.0885716270 14 75084087 75084329 243 - 2.501 2.585 0.281
ENSG00000119638 E009 467.7539694 0.0016577234 6.035333e-01 0.7725355168 14 75084330 75084686 357 - 2.633 2.682 0.163
ENSG00000119638 E010 0.9878233 0.0240631165 7.398294e-01   14 75084859 75085095 237 - 0.247 0.320 0.510
ENSG00000119638 E011 1.7401513 0.0185882027 3.489636e-01 0.5863640087 14 75086429 75086647 219 - 0.517 0.373 -0.752
ENSG00000119638 E012 0.7687085 0.0173510765 3.745432e-01   14 75086648 75086780 133 - 0.332 0.189 -1.076
ENSG00000119638 E013 7.9178228 0.0296725468 1.645929e-01 0.3834833404 14 75086781 75086921 141 - 0.777 1.007 0.879
ENSG00000119638 E014 2.8580349 0.0087121960 5.691031e-01 0.7496009029 14 75086922 75087017 96 - 0.518 0.630 0.509
ENSG00000119638 E015 317.6077266 0.0033291387 6.978983e-01 0.8341751652 14 75087018 75087230 213 - 2.481 2.505 0.082
ENSG00000119638 E016 285.4738391 0.0020515087 9.694589e-01 0.9865735029 14 75088480 75088641 162 - 2.424 2.462 0.127
ENSG00000119638 E017 252.2260399 0.0018341342 7.507150e-01 0.8671902362 14 75091270 75091478 209 - 2.376 2.402 0.086
ENSG00000119638 E018 2.2828486 0.0112436908 2.050678e-01 0.4360019935 14 75091479 75091685 207 - 0.609 0.421 -0.906
ENSG00000119638 E019 108.7609494 0.0006704286 7.489959e-02 0.2346067207 14 75095372 75095431 60 - 2.047 2.013 -0.115
ENSG00000119638 E020 1.1496142 0.0436610267 1.064712e-01   14 75096670 75097099 430 - 0.464 0.189 -1.810
ENSG00000119638 E021 236.3829340 0.0021894319 4.894007e-01 0.6935957629 14 75097100 75097270 171 - 2.358 2.370 0.043
ENSG00000119638 E022 0.4349185 0.0217681645 3.589331e-01   14 75099027 75099317 291 - 0.247 0.104 -1.492
ENSG00000119638 E023 309.0253856 0.0005997513 6.594844e-02 0.2160534344 14 75100992 75101153 162 - 2.486 2.475 -0.036
ENSG00000119638 E024 272.9580568 0.0008826424 9.684313e-03 0.0567658094 14 75101657 75101765 109 - 2.445 2.412 -0.111
ENSG00000119638 E025 5.4482671 0.0093022142 2.385503e-02 0.1086502407 14 75103470 75103841 372 - 0.937 0.658 -1.107
ENSG00000119638 E026 293.6045507 0.0029406608 1.647937e-02 0.0835722233 14 75103842 75103997 156 - 2.483 2.441 -0.138
ENSG00000119638 E027 177.7558835 0.0005816931 5.840435e-05 0.0009521361 14 75105950 75105996 47 - 2.288 2.203 -0.284
ENSG00000119638 E028 36.2134718 0.0887996322 1.367154e-01 0.3424815928 14 75105997 75106190 194 - 1.638 1.505 -0.455
ENSG00000119638 E029 27.9252116 0.1035603153 4.848399e-01 0.6904282278 14 75106191 75106395 205 - 1.465 1.446 -0.064
ENSG00000119638 E030 17.6132285 0.1307920567 1.328746e-01 0.3363205552 14 75106396 75106465 70 - 1.378 1.161 -0.760
ENSG00000119638 E031 28.7807401 0.0199268023 4.154258e-03 0.0300170074 14 75106466 75106501 36 - 1.586 1.358 -0.786
ENSG00000119638 E032 317.6566952 0.0028701758 5.547675e-04 0.0061725928 14 75106502 75106702 201 - 2.537 2.462 -0.251
ENSG00000119638 E033 268.6443158 0.0009948178 7.740671e-05 0.0012071112 14 75107343 75107487 145 - 2.462 2.391 -0.238
ENSG00000119638 E034 5.1421009 0.0056445199 5.283044e-01 0.7208600878 14 75107488 75107755 268 - 0.717 0.827 0.441
ENSG00000119638 E035 2.4554106 0.1151184587 1.726924e-01 0.3940496388 14 75108270 75109684 1415 - 0.649 0.422 -1.073
ENSG00000119638 E036 316.6045844 0.0017821692 7.938272e-03 0.0490307724 14 75109685 75109877 193 - 2.517 2.476 -0.135
ENSG00000119638 E037 208.8446928 0.0003464540 1.059537e-02 0.0606531699 14 75110321 75110371 51 - 2.333 2.297 -0.121
ENSG00000119638 E038 203.4976712 0.0003355423 1.006746e-03 0.0099655300 14 75113339 75113403 65 - 2.332 2.276 -0.188
ENSG00000119638 E039 1.2025117 0.0139420355 3.704000e-01   14 75113404 75113405 2 - 0.403 0.260 -0.901
ENSG00000119638 E040 244.6514400 0.0391726274 8.863273e-01 0.9447574920 14 75114203 75114313 111 - 2.387 2.381 -0.021
ENSG00000119638 E041 1.9929499 0.0105706625 6.366476e-01 0.7947939644 14 75116192 75116410 219 - 0.403 0.503 0.513
ENSG00000119638 E042 136.8884560 1.2564504994 6.035768e-01 0.7725704807 14 75117195 75117212 18 - 2.085 2.163 0.262
ENSG00000119638 E043 202.6800661 1.3871818624 5.998296e-01 0.7701054057 14 75117213 75117326 114 - 2.243 2.338 0.317
ENSG00000119638 E044 117.0960602 1.2120097241 6.226848e-01 0.7856388321 14 75118830 75118868 39 - 2.032 2.087 0.182
ENSG00000119638 E045 140.3728879 1.2719660688 6.198529e-01 0.7837370025 14 75118869 75118935 67 - 2.105 2.168 0.213
ENSG00000119638 E046 93.8315181 0.4013772538 5.925527e-01 0.7652966790 14 75120510 75120515 6 - 1.958 1.978 0.068
ENSG00000119638 E047 139.0925251 0.1036719335 7.755366e-01 0.8820839527 14 75120516 75120580 65 - 2.131 2.146 0.049
ENSG00000119638 E048 0.6182515 0.0203273174 5.377931e-01   14 75120581 75120730 150 - 0.141 0.259 1.095
ENSG00000119638 E049 0.1426347 0.0311968041 3.307083e-01   14 75120872 75121007 136 - 0.140 0.000 -11.793
ENSG00000119638 E050 130.6826586 0.0076720677 7.694007e-02 0.2386650216 14 75121119 75121174 56 - 2.151 2.084 -0.224
ENSG00000119638 E051 189.7278790 0.0002603205 6.641542e-06 0.0001472629 14 75124046 75124223 178 - 2.323 2.234 -0.299
ENSG00000119638 E052 13.6164802 0.0162954150 1.981191e-02 0.0952500593 14 75126341 75126588 248 - 0.973 1.262 1.043
ENSG00000119638 E053 9.8288027 0.0409184966 8.926932e-03 0.0534936775 14 75126589 75126702 114 - 0.747 1.160 1.550
ENSG00000119638 E054 180.7415256 0.0158525353 1.720627e-01 0.3932838926 14 75126703 75126904 202 - 2.172 2.300 0.429
ENSG00000119638 E055 116.0909175 0.0235831488 5.431647e-02 0.1898221048 14 75126905 75127053 149 - 1.933 2.131 0.664
ENSG00000119638 E056 2.8573650 0.0118826170 7.179365e-01 0.8469461740 14 75127122 75127344 223 - 0.608 0.571 -0.164