ENSG00000119616

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341162 ENSG00000119616 HEK293_OSMI2_6hA HEK293_TMG_6hB FCF1 protein_coding protein_coding 29.15001 10.95274 48.25959 1.487877 1.630954 2.138506 6.283725 3.1211800 8.875920 0.46936690 0.3669452 1.504815 0.25444167 0.28373333 0.18390000 -0.09983333 0.01084332 0.01084332 FALSE TRUE
ENST00000534938 ENSG00000119616 HEK293_OSMI2_6hA HEK293_TMG_6hB FCF1 protein_coding protein_coding 29.15001 10.95274 48.25959 1.487877 1.630954 2.138506 15.425484 6.7102472 26.055263 1.03906432 2.3788579 1.955542 0.52574583 0.60946667 0.53786667 -0.07160000 0.71257965 0.01084332 FALSE TRUE
ENST00000554590 ENSG00000119616 HEK293_OSMI2_6hA HEK293_TMG_6hB FCF1 protein_coding protein_coding 29.15001 10.95274 48.25959 1.487877 1.630954 2.138506 1.387460 0.1088780 3.002381 0.05532771 0.5858403 4.663350 0.03642917 0.01133333 0.06173333 0.05040000 0.11541502 0.01084332   FALSE
ENST00000556814 ENSG00000119616 HEK293_OSMI2_6hA HEK293_TMG_6hB FCF1 protein_coding nonsense_mediated_decay 29.15001 10.95274 48.25959 1.487877 1.630954 2.138506 4.930402 0.6869374 9.523352 0.35221883 1.3100195 3.773882 0.13954583 0.06396667 0.19950000 0.13553333 0.53931402 0.01084332 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119616 E001 2.6648926 0.0082944367 4.521447e-02 1.681432e-01 14 74713144 74713161 18 + 0.591 0.197 -2.341
ENSG00000119616 E002 6.0688037 0.0118907369 1.795586e-01 4.033820e-01 14 74713162 74713167 6 + 0.845 0.646 -0.808
ENSG00000119616 E003 6.7288218 0.0150669593 1.031170e-01 2.873871e-01 14 74713168 74713169 2 + 0.888 0.645 -0.976
ENSG00000119616 E004 55.7601862 0.0006643105 1.914948e-01 4.187680e-01 14 74713170 74713200 31 + 1.710 1.643 -0.227
ENSG00000119616 E005 6.8317829 0.0039419005 9.904825e-02 2.800924e-01 14 74713201 74713203 3 + 0.887 0.647 -0.966
ENSG00000119616 E006 19.8695286 0.0016767007 9.384995e-01 9.715554e-01 14 74713204 74713259 56 + 1.261 1.273 0.043
ENSG00000119616 E007 86.2669337 0.0007148009 9.652576e-01 9.845280e-01 14 74713485 74713507 23 + 1.881 1.884 0.010
ENSG00000119616 E008 104.4141846 0.0024642048 9.634924e-01 9.837004e-01 14 74713508 74713552 45 + 1.964 1.967 0.012
ENSG00000119616 E009 4.1882104 0.0064497241 1.090256e-01 2.974496e-01 14 74713553 74713620 68 + 0.714 0.435 -1.278
ENSG00000119616 E010 124.9068572 0.0018451075 6.757106e-01 8.200021e-01 14 74714872 74714943 72 + 2.044 2.032 -0.040
ENSG00000119616 E011 0.9217543 0.0160961311 6.298270e-01   14 74715672 74715820 149 + 0.237 0.331 0.655
ENSG00000119616 E012 3.4498885 0.1256833588 1.594105e-01 3.758608e-01 14 74715821 74715950 130 + 0.509 0.786 1.200
ENSG00000119616 E013 117.5235594 0.0023401959 8.397011e-01 9.192204e-01 14 74715951 74715993 43 + 2.015 2.009 -0.020
ENSG00000119616 E014 208.4634713 0.0004092522 4.813757e-03 3.360961e-02 14 74715994 74716099 106 + 2.278 2.200 -0.259
ENSG00000119616 E015 205.7664232 0.0004616302 5.191383e-04 5.848200e-03 14 74723272 74723344 73 + 2.275 2.177 -0.326
ENSG00000119616 E016 205.9354454 0.0003131178 2.209639e-03 1.846205e-02 14 74732731 74732818 88 + 2.274 2.191 -0.277
ENSG00000119616 E017 223.6766542 0.0002119533 7.583312e-02 2.364449e-01 14 74734076 74734170 95 + 2.299 2.256 -0.143
ENSG00000119616 E018 584.2883959 0.0017454878 2.566667e-01 4.954242e-01 14 74734882 74735670 789 + 2.696 2.722 0.087
ENSG00000119616 E019 249.4975012 0.0006876758 6.448016e-12 5.748144e-10 14 74735671 74736319 649 + 2.284 2.463 0.597
ENSG00000119616 E020 159.9750824 0.0003366789 1.977143e-03 1.691613e-02 14 74736320 74738620 2301 + 2.118 2.219 0.337