ENSG00000119522

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373624 ENSG00000119522 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND1A protein_coding protein_coding 14.9894 17.88285 11.1892 2.212354 0.7943375 -0.6759872 6.0801017 10.3545827 3.7036155 1.98663034 0.2742244 -1.4807657 0.3952542 0.56810000 0.33210000 -0.23600000 0.02389776 0.01739285 FALSE TRUE
ENST00000475421 ENSG00000119522 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND1A protein_coding processed_transcript 14.9894 17.88285 11.1892 2.212354 0.7943375 -0.6759872 2.6960577 2.5468486 0.9516119 0.08567205 0.4860509 -1.4108401 0.1613958 0.14893333 0.08050000 -0.06843333 0.76762854 0.01739285 FALSE FALSE
MSTRG.33350.15 ENSG00000119522 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND1A protein_coding   14.9894 17.88285 11.1892 2.212354 0.7943375 -0.6759872 0.7682344 0.3198213 0.8502914 0.16128059 0.1196472 1.3831408 0.0562375 0.01593333 0.07833333 0.06240000 0.27223038 0.01739285 FALSE TRUE
MSTRG.33350.6 ENSG00000119522 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND1A protein_coding   14.9894 17.88285 11.1892 2.212354 0.7943375 -0.6759872 0.5747712 0.4223890 1.0228833 0.37514196 0.1636316 1.2562756 0.0472625 0.03060000 0.09440000 0.06380000 0.35922798 0.01739285 FALSE TRUE
MSTRG.33350.8 ENSG00000119522 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND1A protein_coding   14.9894 17.88285 11.1892 2.212354 0.7943375 -0.6759872 3.8361482 3.2364474 3.8560385 0.63267037 0.4495526 0.2519942 0.2695625 0.18036667 0.34246667 0.16210000 0.01739285 0.01739285 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119522 E001 0.9760568 0.0174077745 4.524148e-01   9 123379654 123379657 4 - 0.169 0.321 1.203
ENSG00000119522 E002 69.1119217 0.0135126540 7.385245e-06 1.612684e-04 9 123379658 123379880 223 - 1.537 1.901 1.234
ENSG00000119522 E003 273.3753991 0.0156808336 1.408671e-03 1.296254e-02 9 123379881 123380820 940 - 2.239 2.464 0.753
ENSG00000119522 E004 117.7064732 0.0074708700 3.320522e-02 1.365940e-01 9 123380821 123381033 213 - 1.938 2.084 0.490
ENSG00000119522 E005 135.2976982 0.0008068391 2.236244e-05 4.204202e-04 9 123381034 123381435 402 - 1.978 2.154 0.592
ENSG00000119522 E006 127.9791265 0.0051771379 6.587194e-05 1.054044e-03 9 123381436 123382219 784 - 1.917 2.139 0.745
ENSG00000119522 E007 106.3737480 0.0004727037 4.293326e-07 1.354963e-05 9 123382220 123382625 406 - 1.835 2.059 0.753
ENSG00000119522 E008 91.5998205 0.0008056989 1.039481e-01 2.887585e-01 9 123383655 123383913 259 - 1.873 1.964 0.305
ENSG00000119522 E009 4.4428757 0.0291231326 8.914308e-01 9.473492e-01 9 123387730 123387858 129 - 0.722 0.726 0.015
ENSG00000119522 E010 0.3393995 0.0255018508 5.741075e-02   9 123400099 123400169 71 - 0.290 0.000 -13.337
ENSG00000119522 E011 0.6482515 0.0459122667 7.250876e-02   9 123400170 123400231 62 - 0.386 0.086 -2.711
ENSG00000119522 E012 5.7793783 0.0049356297 9.780228e-01 9.907763e-01 9 123400232 123401547 1316 - 0.794 0.811 0.067
ENSG00000119522 E013 13.9802364 0.0060608117 3.381107e-01 5.763775e-01 9 123401548 123401704 157 - 1.059 1.177 0.426
ENSG00000119522 E014 46.4703342 0.0012838943 2.892685e-01 5.297863e-01 9 123401705 123401912 208 - 1.668 1.630 -0.130
ENSG00000119522 E015 85.0491456 0.0006276573 8.470801e-01 9.233583e-01 9 123403402 123403474 73 - 1.897 1.912 0.051
ENSG00000119522 E016 50.2899849 0.0007290762 5.082437e-01 7.066544e-01 9 123403475 123403490 16 - 1.690 1.678 -0.041
ENSG00000119522 E017 0.1426347 0.0313080440 2.139099e-01   9 123403491 123403573 83 - 0.169 0.000 -12.333
ENSG00000119522 E018 0.1723744 0.0428354796 1.000000e+00   9 123411293 123411775 483 - 0.000 0.086 10.070
ENSG00000119522 E019 0.8156366 0.0167555890 1.776093e-01   9 123411776 123411829 54 - 0.385 0.158 -1.701
ENSG00000119522 E020 1.3852245 0.4438211967 9.121136e-01   9 123413271 123414588 1318 - 0.290 0.376 0.535
ENSG00000119522 E021 0.1723744 0.0428354796 1.000000e+00   9 123437647 123437832 186 - 0.000 0.086 10.070
ENSG00000119522 E022 0.4764247 0.0208977037 2.037601e-01   9 123439727 123440189 463 - 0.290 0.086 -2.114
ENSG00000119522 E023 107.8928027 0.0023247248 7.608797e-01 8.730971e-01 9 123440360 123440491 132 - 1.998 2.009 0.035
ENSG00000119522 E024 81.0379196 0.0008090581 3.730362e-03 2.763605e-02 9 123450693 123450749 57 - 1.946 1.847 -0.335
ENSG00000119522 E025 81.5409993 0.0004794569 4.535327e-04 5.253413e-03 9 123452276 123452347 72 - 1.965 1.845 -0.402
ENSG00000119522 E026 60.1441769 0.0007685796 1.132994e-02 6.372293e-02 9 123454739 123454779 41 - 1.820 1.722 -0.332
ENSG00000119522 E027 0.4054685 0.4958562745 6.620679e-01   9 123456847 123456931 85 - 0.000 0.166 11.152
ENSG00000119522 E028 87.1193744 0.0005273991 2.941676e-02 1.256165e-01 9 123457348 123457435 88 - 1.958 1.893 -0.219
ENSG00000119522 E029 94.0306660 0.0018874271 3.979418e-01 6.267288e-01 9 123457793 123457897 105 - 1.957 1.940 -0.057
ENSG00000119522 E030 0.0000000       9 123461914 123462023 110 -      
ENSG00000119522 E031 103.8314635 0.0005370719 2.218674e-02 1.032302e-01 9 123557570 123557695 126 - 2.029 1.967 -0.210
ENSG00000119522 E032 3.7717474 0.0494636558 8.356625e-04 8.571281e-03 9 123569443 123569544 102 - 0.937 0.403 -2.323
ENSG00000119522 E033 3.4912300 0.0564941818 2.418160e-04 3.130024e-03 9 123569545 123569595 51 - 0.937 0.322 -2.797
ENSG00000119522 E034 89.4914729 0.0005998721 3.860494e-04 4.596513e-03 9 123583169 123583270 102 - 2.001 1.884 -0.393
ENSG00000119522 E035 56.6981286 0.0033746812 2.537176e-03 2.057547e-02 9 123609436 123609481 46 - 1.820 1.675 -0.490
ENSG00000119522 E036 50.0468303 0.0008886054 3.592453e-03 2.689122e-02 9 123630376 123630395 20 - 1.760 1.630 -0.440
ENSG00000119522 E037 73.2968188 0.0033499584 8.246885e-02 2.496700e-01 9 123630396 123630476 81 - 1.881 1.814 -0.228
ENSG00000119522 E038 95.9269420 0.0035353647 1.244642e-01 3.228528e-01 9 123652013 123652123 111 - 1.985 1.934 -0.170
ENSG00000119522 E039 0.0000000       9 123652124 123652291 168 -      
ENSG00000119522 E040 76.9477074 0.0091736267 2.390401e-01 4.755149e-01 9 123667026 123667079 54 - 1.893 1.839 -0.183
ENSG00000119522 E041 86.2420015 0.0006686102 3.862908e-02 1.511963e-01 9 123671291 123671371 81 - 1.949 1.887 -0.209
ENSG00000119522 E042 89.5545824 0.0004435714 3.213256e-02 1.336120e-01 9 123676720 123676789 70 - 1.969 1.908 -0.205
ENSG00000119522 E043 105.4410871 0.0021683633 1.035697e-01 2.881554e-01 9 123757703 123757822 120 - 2.029 1.982 -0.157
ENSG00000119522 E044 63.9848233 0.0126752632 9.533181e-01 9.786068e-01 9 123769514 123769563 50 - 1.766 1.788 0.073
ENSG00000119522 E045 64.4471895 0.0104069926 5.644711e-01 7.464016e-01 9 123792587 123792630 44 - 1.800 1.778 -0.072
ENSG00000119522 E046 0.0000000       9 123798261 123798515 255 -      
ENSG00000119522 E047 60.3175587 0.0011121580 3.916638e-02 1.525999e-01 9 123878951 123879021 71 - 1.814 1.735 -0.264
ENSG00000119522 E048 3.0543336 0.2378553803 1.250162e-01 3.237461e-01 9 123928595 123928727 133 - 0.798 0.436 -1.610
ENSG00000119522 E049 38.7390115 0.0157021784 3.751773e-01 6.083270e-01 9 123929889 123930152 264 - 1.613 1.551 -0.212