ENSG00000119509

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262456 ENSG00000119509 HEK293_OSMI2_6hA HEK293_TMG_6hB INVS protein_coding protein_coding 5.127959 3.610622 6.316064 0.5740205 0.3327732 0.8050704 0.8690326 0.3300355 1.0223457 0.09008251 0.2072504 1.6021690 0.15931250 0.08763333 0.16306667 0.07543333 0.534419625 0.001043247 FALSE  
ENST00000262457 ENSG00000119509 HEK293_OSMI2_6hA HEK293_TMG_6hB INVS protein_coding protein_coding 5.127959 3.610622 6.316064 0.5740205 0.3327732 0.8050704 2.4463451 2.0229645 3.1407704 0.47367991 0.3913300 0.6321196 0.49997083 0.54546667 0.50263333 -0.04283333 0.939550028 0.001043247 FALSE  
ENST00000460636 ENSG00000119509 HEK293_OSMI2_6hA HEK293_TMG_6hB INVS protein_coding processed_transcript 5.127959 3.610622 6.316064 0.5740205 0.3327732 0.8050704 0.3923681 0.0000000 0.3191335 0.00000000 0.0260332 5.0406012 0.06949167 0.00000000 0.05110000 0.05110000 0.001043247 0.001043247 FALSE  
ENST00000496467 ENSG00000119509 HEK293_OSMI2_6hA HEK293_TMG_6hB INVS protein_coding processed_transcript 5.127959 3.610622 6.316064 0.5740205 0.3327732 0.8050704 0.1059287 0.0000000 0.4255202 0.00000000 0.4255202 5.4446676 0.01488750 0.00000000 0.06206667 0.06206667 0.926052079 0.001043247    
MSTRG.33154.7 ENSG00000119509 HEK293_OSMI2_6hA HEK293_TMG_6hB INVS protein_coding   5.127959 3.610622 6.316064 0.5740205 0.3327732 0.8050704 0.3190408 0.3443762 0.5417577 0.09231654 0.2279272 0.6387529 0.06036667 0.09143333 0.08523333 -0.00620000 0.949331240 0.001043247 TRUE  
MSTRG.33154.9 ENSG00000119509 HEK293_OSMI2_6hA HEK293_TMG_6hB INVS protein_coding   5.127959 3.610622 6.316064 0.5740205 0.3327732 0.8050704 0.2639355 0.5131742 0.1322548 0.11235079 0.1322548 -1.8788140 0.05773333 0.16266667 0.01930000 -0.14336667 0.192747333 0.001043247 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119509 E001 0.5530924 0.0274738478 0.463152435   9 100099243 100099250 8 + 0.113 0.232 1.248
ENSG00000119509 E002 1.0343188 0.0660521282 0.314677064   9 100099251 100099260 10 + 0.203 0.382 1.245
ENSG00000119509 E003 1.4987893 0.0123473799 0.051264099 0.18276106 9 100099261 100099271 11 + 0.202 0.539 2.052
ENSG00000119509 E004 1.8020318 0.0113869080 0.014610571 0.07663025 9 100099272 100099274 3 + 0.202 0.619 2.414
ENSG00000119509 E005 2.9347026 0.0076278784 0.024299648 0.11002317 9 100099275 100099287 13 + 0.395 0.746 1.624
ENSG00000119509 E006 4.2690101 0.0061686430 0.031186030 0.13089051 9 100099288 100099302 15 + 0.564 0.864 1.244
ENSG00000119509 E007 16.1173544 0.0027033371 0.496234214 0.69835341 9 100099303 100099416 114 + 1.207 1.260 0.186
ENSG00000119509 E008 5.1829096 0.0571872912 0.124790048 0.32340216 9 100101301 100102017 717 + 0.895 0.619 -1.120
ENSG00000119509 E009 14.6856456 0.0032589632 0.775655492 0.88215417 9 100104498 100104538 41 + 1.207 1.177 -0.108
ENSG00000119509 E010 25.5321061 0.0015019816 0.783002414 0.88642561 9 100104539 100104627 89 + 1.433 1.408 -0.085
ENSG00000119509 E011 42.1174730 0.0015903943 0.142137575 0.35061703 9 100126383 100126549 167 + 1.674 1.586 -0.298
ENSG00000119509 E012 4.0836176 0.0063982517 0.136515452 0.34216390 9 100129676 100130903 1228 + 0.801 0.581 -0.924
ENSG00000119509 E013 0.8461841 0.0172671820 0.242432211   9 100131870 100131954 85 + 0.339 0.131 -1.751
ENSG00000119509 E014 3.9026425 0.0878811833 0.173878539 0.39570528 9 100214925 100215040 116 + 0.562 0.801 1.007
ENSG00000119509 E015 5.8900236 0.1334850498 0.576364270 0.75469301 9 100215401 100215488 88 + 0.812 0.882 0.272
ENSG00000119509 E016 44.6829756 0.0188052125 0.037685981 0.14880482 9 100226062 100226235 174 + 1.738 1.551 -0.636
ENSG00000119509 E017 37.7308456 0.0011831206 0.019968068 0.09576206 9 100229660 100229827 168 + 1.652 1.513 -0.472
ENSG00000119509 E018 45.1380961 0.0010477148 0.375483566 0.60857471 9 100240060 100240240 181 + 1.690 1.638 -0.175
ENSG00000119509 E019 40.5245499 0.0020444502 0.372546334 0.60608932 9 100242570 100242679 110 + 1.643 1.586 -0.194
ENSG00000119509 E020 43.8172435 0.0115015646 0.179209524 0.40289362 9 100246616 100246787 172 + 1.695 1.584 -0.377
ENSG00000119509 E021 44.2806885 0.0129707742 0.215027135 0.44759454 9 100252283 100252438 156 + 1.701 1.596 -0.356
ENSG00000119509 E022 48.4836991 0.0009110949 0.620721668 0.78432738 9 100252907 100253136 230 + 1.687 1.706 0.064
ENSG00000119509 E023 32.2562834 0.0012428913 0.957769086 0.98072727 9 100264822 100264928 107 + 1.522 1.514 -0.030
ENSG00000119509 E024 49.4525617 0.0035294576 0.570665269 0.75076181 9 100272864 100273076 213 + 1.720 1.682 -0.129
ENSG00000119509 E025 64.2983692 0.0008998962 0.728167798 0.85314670 9 100284320 100284603 284 + 1.807 1.817 0.034
ENSG00000119509 E026 29.0422412 0.0036713998 0.447825535 0.66410401 9 100292326 100292374 49 + 1.503 1.447 -0.194
ENSG00000119509 E027 35.8379811 0.0060230941 0.913643223 0.95892335 9 100292375 100292436 62 + 1.564 1.568 0.013
ENSG00000119509 E028 68.7096829 0.0008589015 0.007140279 0.04528114 9 100292437 100292873 437 + 1.791 1.899 0.366
ENSG00000119509 E029 20.7633151 0.0047243504 0.107756969 0.29532651 9 100292874 100292946 73 + 1.280 1.402 0.423
ENSG00000119509 E030 38.1354861 0.0011885655 0.808471969 0.90126907 9 100292947 100293043 97 + 1.593 1.602 0.029
ENSG00000119509 E031 61.8213915 0.0007203551 0.037741441 0.14893377 9 100296917 100297146 230 + 1.756 1.842 0.291
ENSG00000119509 E032 41.1692564 0.0010622324 0.007992598 0.04927313 9 100297936 100298010 75 + 1.556 1.694 0.472
ENSG00000119509 E033 109.6481093 0.0037283126 0.556223956 0.74064631 9 100300568 100302175 1608 + 2.032 2.053 0.069