ENSG00000119487

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350766 ENSG00000119487 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPKAP1 protein_coding protein_coding 53.46233 40.24816 65.98958 7.668459 1.987617 0.7131755 7.776214 6.784148 7.673944 1.3792700 0.6989738 0.1775543 0.15074583 0.17096667 0.11710000 -0.053866667 0.4797934089 8.434287e-11 FALSE TRUE
ENST00000373498 ENSG00000119487 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPKAP1 protein_coding protein_coding 53.46233 40.24816 65.98958 7.668459 1.987617 0.7131755 13.934078 8.793361 15.928750 0.9041844 1.3424613 0.8564122 0.26124583 0.22966667 0.24070000 0.011033333 0.9635443323 8.434287e-11 FALSE TRUE
ENST00000420643 ENSG00000119487 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPKAP1 protein_coding protein_coding 53.46233 40.24816 65.98958 7.668459 1.987617 0.7131755 3.707670 2.966932 7.956683 1.0446188 0.5308019 1.4201528 0.06354583 0.07553333 0.12033333 0.044800000 0.5705438031 8.434287e-11 FALSE TRUE
ENST00000444226 ENSG00000119487 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPKAP1 protein_coding protein_coding 53.46233 40.24816 65.98958 7.668459 1.987617 0.7131755 2.557040 5.902412 2.266367 2.0369001 1.1776412 -1.3770137 0.05257083 0.13563333 0.03353333 -0.102100000 0.5757777373 8.434287e-11 FALSE FALSE
ENST00000496658 ENSG00000119487 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPKAP1 protein_coding processed_transcript 53.46233 40.24816 65.98958 7.668459 1.987617 0.7131755 3.040760 0.000000 2.364535 0.0000000 1.5327953 7.8915014 0.06424167 0.00000000 0.03693333 0.036933333 0.3757783813 8.434287e-11   FALSE
MSTRG.33390.12 ENSG00000119487 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPKAP1 protein_coding   53.46233 40.24816 65.98958 7.668459 1.987617 0.7131755 5.286803 5.214298 8.172359 1.2752830 0.9822771 0.6472796 0.09572083 0.12623333 0.12316667 -0.003066667 0.9920017916 8.434287e-11 FALSE TRUE
MSTRG.33390.13 ENSG00000119487 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPKAP1 protein_coding   53.46233 40.24816 65.98958 7.668459 1.987617 0.7131755 9.662536 4.864211 14.435660 0.6773828 0.3675964 1.5673955 0.17285417 0.12410000 0.21883333 0.094733333 0.0007838413 8.434287e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119487 E001 0.0000000       9 125437393 125437393 1 -      
ENSG00000119487 E002 352.8371371 0.3152837610 1.995560e-01 4.291277e-01 9 125437394 125438468 1075 - 2.432 2.655 0.744
ENSG00000119487 E003 211.9470042 0.0262164280 4.394006e-02 1.649359e-01 9 125438469 125438625 157 - 2.248 2.408 0.533
ENSG00000119487 E004 109.7626938 0.0005771515 1.027939e-03 1.012833e-02 9 125438626 125438628 3 - 1.984 2.116 0.441
ENSG00000119487 E005 123.1185648 0.0008439573 6.736582e-04 7.212827e-03 9 125438629 125438654 26 - 2.033 2.166 0.445
ENSG00000119487 E006 142.6487947 0.0003618235 4.848496e-04 5.537230e-03 9 125438655 125438706 52 - 2.099 2.221 0.409
ENSG00000119487 E007 282.2557673 0.0003779134 6.784829e-05 1.080476e-03 9 125438707 125438812 106 - 2.400 2.507 0.354
ENSG00000119487 E008 443.1135615 0.0005024717 9.029486e-04 9.117155e-03 9 125438813 125439012 200 - 2.609 2.690 0.272
ENSG00000119487 E009 326.9034882 0.0002188860 2.568216e-01 4.956048e-01 9 125444501 125444598 98 - 2.497 2.537 0.134
ENSG00000119487 E010 0.4458772 0.0217681645 4.652612e-01   9 125447325 125447487 163 - 0.110 0.236 1.321
ENSG00000119487 E011 0.8323924 0.0170712353 2.423530e-01   9 125451058 125451101 44 - 0.334 0.134 -1.679
ENSG00000119487 E012 372.1770588 0.0015361507 9.449941e-01 9.747906e-01 9 125467972 125468109 138 - 2.563 2.579 0.052
ENSG00000119487 E013 1.0877114 0.1333149473 5.379968e-02   9 125471083 125471237 155 - 0.111 0.496 2.880
ENSG00000119487 E014 2.8616485 0.0720978123 1.199329e-03 1.142822e-02 9 125471238 125471905 668 - 0.198 0.811 3.244
ENSG00000119487 E015 1.3327596 0.0253813653 3.394664e-01   9 125478080 125478182 103 - 0.271 0.448 1.061
ENSG00000119487 E016 366.0132367 0.0012739255 8.162802e-02 2.481037e-01 9 125484443 125484583 141 - 2.574 2.548 -0.087
ENSG00000119487 E017 1.4133421 0.1824217282 6.938047e-02 2.235240e-01 9 125505944 125506309 366 - 0.520 0.132 -2.698
ENSG00000119487 E018 124.6481964 0.0004194593 1.861585e-02 9.111449e-02 9 125506310 125506417 108 - 2.053 2.146 0.311
ENSG00000119487 E019 0.6494192 0.0204007814 4.124259e-01   9 125521468 125521517 50 - 0.271 0.134 -1.259
ENSG00000119487 E020 4.9396269 0.0075674399 3.261603e-01 5.653279e-01 9 125521518 125521644 127 - 0.703 0.852 0.597
ENSG00000119487 E021 11.9736072 0.0586051984 7.181378e-01 8.470870e-01 9 125521645 125521765 121 - 1.132 1.090 -0.152
ENSG00000119487 E022 351.5406781 0.0012249225 2.686375e-01 5.083086e-01 9 125543059 125543168 110 - 2.550 2.540 -0.033
ENSG00000119487 E023 0.6268817 0.1405695083 8.171778e-02   9 125559114 125559632 519 - 0.333 0.000 -12.902
ENSG00000119487 E024 361.7056596 0.0002401901 9.623102e-01 9.831435e-01 9 125559633 125559782 150 - 2.550 2.569 0.061
ENSG00000119487 E025 178.9104997 0.0004930336 9.896627e-01 9.965578e-01 9 125559783 125559809 27 - 2.247 2.264 0.058
ENSG00000119487 E026 2.5693353 0.0090365443 3.971301e-01 6.260206e-01 9 125565366 125565737 372 - 0.480 0.628 0.683
ENSG00000119487 E027 397.2141615 0.0009770516 1.284562e-02 6.980293e-02 9 125585555 125585727 173 - 2.616 2.579 -0.124
ENSG00000119487 E028 0.1779838 0.0411223853 5.847940e-01   9 125595510 125595646 137 - 0.110 0.000 -10.908
ENSG00000119487 E029 0.3447487 0.7170715134 3.092648e-01   9 125599835 125599927 93 - 0.000 0.240 12.540
ENSG00000119487 E030 0.0000000       9 125650364 125650461 98 -      
ENSG00000119487 E031 0.4654660 0.0251580361 1.201493e-01   9 125652117 125652257 141 - 0.271 0.000 -12.490
ENSG00000119487 E032 172.3528920 0.0010131106 1.082047e-03 1.054436e-02 9 125657651 125657668 18 - 2.275 2.193 -0.273
ENSG00000119487 E033 327.3715661 0.0002673717 7.296031e-04 7.692518e-03 9 125657669 125657799 131 - 2.540 2.489 -0.170
ENSG00000119487 E034 240.7516655 0.0002434925 3.526913e-06 8.542496e-05 9 125669818 125669886 69 - 2.424 2.332 -0.306
ENSG00000119487 E035 199.6836820 0.0009293968 1.773311e-06 4.688604e-05 9 125669887 125669907 21 - 2.351 2.228 -0.410
ENSG00000119487 E036 261.6896692 0.0004240806 3.431275e-11 2.675433e-09 9 125672316 125672399 84 - 2.476 2.334 -0.471
ENSG00000119487 E037 349.1838548 0.0005013210 3.000032e-10 1.921095e-08 9 125672400 125672643 244 - 2.592 2.474 -0.394
ENSG00000119487 E038 0.5421338 0.0228228567 6.836748e-01   9 125696217 125696404 188 - 0.198 0.134 -0.678
ENSG00000119487 E039 156.2464816 0.0041911146 2.020565e-01 4.321588e-01 9 125706971 125707234 264 - 2.160 2.237 0.256