ENSG00000119397

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373850 ENSG00000119397 HEK293_OSMI2_6hA HEK293_TMG_6hB CNTRL protein_coding protein_coding 3.003432 2.407609 4.37798 0.3993672 0.2151308 0.859976 0.2655394 0.1092160 0.9565999 0.10921597 0.26793551 3.0193414 0.07315417 0.03430000 0.22236667 0.188066667 2.501554e-01 1.595192e-10 FALSE TRUE
ENST00000373855 ENSG00000119397 HEK293_OSMI2_6hA HEK293_TMG_6hB CNTRL protein_coding protein_coding 3.003432 2.407609 4.37798 0.3993672 0.2151308 0.859976 0.2198464 0.0000000 0.1826292 0.00000000 0.18262924 4.2677548 0.06495417 0.00000000 0.04166667 0.041666667 9.241878e-01 1.595192e-10 FALSE TRUE
ENST00000689304 ENSG00000119397 HEK293_OSMI2_6hA HEK293_TMG_6hB CNTRL protein_coding nonsense_mediated_decay 3.003432 2.407609 4.37798 0.3993672 0.2151308 0.859976 0.2821170 0.5796301 0.0000000 0.01586779 0.00000000 -5.8817382 0.14889583 0.25140000 0.00000000 -0.251400000 1.595192e-10 1.595192e-10 FALSE TRUE
ENST00000689516 ENSG00000119397 HEK293_OSMI2_6hA HEK293_TMG_6hB CNTRL protein_coding retained_intron 3.003432 2.407609 4.37798 0.3993672 0.2151308 0.859976 0.1762675 0.1355630 0.2685940 0.02999894 0.04074907 0.9365201 0.05505833 0.05623333 0.06160000 0.005366667 9.546516e-01 1.595192e-10 FALSE TRUE
ENST00000689934 ENSG00000119397 HEK293_OSMI2_6hA HEK293_TMG_6hB CNTRL protein_coding protein_coding 3.003432 2.407609 4.37798 0.3993672 0.2151308 0.859976 0.1914538 0.2325910 0.3243348 0.14357670 0.20116656 0.4627673 0.05203750 0.08283333 0.06993333 -0.012900000 9.696657e-01 1.595192e-10   FALSE
MSTRG.33317.13 ENSG00000119397 HEK293_OSMI2_6hA HEK293_TMG_6hB CNTRL protein_coding   3.003432 2.407609 4.37798 0.3993672 0.2151308 0.859976 0.2189003 0.0000000 0.6256473 0.00000000 0.32241837 5.9901545 0.06757083 0.00000000 0.14583333 0.145833333 4.140852e-01 1.595192e-10 FALSE TRUE
MSTRG.33317.19 ENSG00000119397 HEK293_OSMI2_6hA HEK293_TMG_6hB CNTRL protein_coding   3.003432 2.407609 4.37798 0.3993672 0.2151308 0.859976 0.6554330 0.5482273 0.8085083 0.13538828 0.44841622 0.5521444 0.22054167 0.25496667 0.17930000 -0.075666667 8.763158e-01 1.595192e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119397 E001 0.2027342 0.060649132 0.236327850   9 121074660 121074879 220 + 0.000 0.166 11.557
ENSG00000119397 E002 0.2027342 0.060649132 0.236327850   9 121074880 121074895 16 + 0.000 0.166 13.471
ENSG00000119397 E003 0.3453689 0.037625221 0.592530962   9 121074896 121074954 59 + 0.088 0.166 1.054
ENSG00000119397 E004 0.1426347 0.032295808 1.000000000   9 121074955 121074958 4 + 0.088 0.000 -11.463
ENSG00000119397 E005 0.1426347 0.032295808 1.000000000   9 121074959 121074961 3 + 0.088 0.000 -11.463
ENSG00000119397 E006 0.4279040 0.589000462 0.541266383   9 121074962 121074967 6 + 0.217 0.000 -13.001
ENSG00000119397 E007 1.6846160 0.142030385 0.853394923 0.926841553 9 121074968 121075000 33 + 0.441 0.380 -0.331
ENSG00000119397 E008 1.6846160 0.142030385 0.853394923 0.926841553 9 121075001 121075004 4 + 0.441 0.380 -0.331
ENSG00000119397 E009 2.3528163 0.196469014 0.861438252 0.931145399 9 121075005 121075067 63 + 0.532 0.461 -0.350
ENSG00000119397 E010 0.1614157 0.036327013 1.000000000   9 121080306 121080307 2 + 0.088 0.000 -11.466
ENSG00000119397 E011 0.3228314 0.521491231 0.639806106   9 121080308 121080311 4 + 0.162 0.000 -12.487
ENSG00000119397 E012 2.4928782 0.016033730 0.070795889 0.226315230 9 121080312 121080427 116 + 0.616 0.285 -1.756
ENSG00000119397 E013 2.8676269 0.007870888 0.034869869 0.141270461 9 121080428 121080478 51 + 0.662 0.285 -1.952
ENSG00000119397 E014 7.3963840 0.004587213 0.027651395 0.120266684 9 121088296 121088543 248 + 0.969 0.673 -1.162
ENSG00000119397 E015 5.3853163 0.088971478 0.086777344 0.257825482 9 121090275 121090405 131 + 0.863 0.525 -1.421
ENSG00000119397 E016 3.7287635 0.007098688 0.816128457 0.905902543 9 121094888 121095018 131 + 0.662 0.628 -0.146
ENSG00000119397 E017 6.3534823 0.004378821 0.707625522 0.840310256 9 121096422 121096563 142 + 0.862 0.817 -0.176
ENSG00000119397 E018 8.2532843 0.003606559 0.227529681 0.462387926 9 121098386 121098572 187 + 0.989 0.847 -0.539
ENSG00000119397 E019 0.1614157 0.036327013 1.000000000   9 121098573 121098850 278 + 0.088 0.000 -11.466
ENSG00000119397 E020 6.0680973 0.023693689 0.143743012 0.352997984 9 121107802 121107995 194 + 0.889 0.672 -0.866
ENSG00000119397 E021 1.0666018 0.049376789 0.802159828   9 121107996 121108459 464 + 0.327 0.284 -0.286
ENSG00000119397 E022 0.0000000       9 121110515 121110536 22 +      
ENSG00000119397 E023 0.0000000       9 121110537 121110571 35 +      
ENSG00000119397 E024 0.3040503 0.027442404 0.488933777   9 121110572 121111062 491 + 0.161 0.000 -12.457
ENSG00000119397 E025 0.3393995 0.024841893 0.487016951   9 121111063 121111274 212 + 0.161 0.000 -12.459
ENSG00000119397 E026 1.0241679 0.015378759 0.383197948   9 121111275 121112458 1184 + 0.327 0.166 -1.274
ENSG00000119397 E027 3.7537717 0.007363997 0.712049095 0.843128367 9 121112459 121112578 120 + 0.682 0.628 -0.232
ENSG00000119397 E028 0.0000000       9 121112579 121113501 923 +      
ENSG00000119397 E029 6.8053288 0.004446806 0.775804850 0.882253133 9 121113502 121113724 223 + 0.862 0.901 0.147
ENSG00000119397 E030 5.0141855 0.005797056 0.222203289 0.456110423 9 121115091 121115200 110 + 0.805 0.628 -0.729
ENSG00000119397 E031 8.3378446 0.003756985 0.195995400 0.424538637 9 121118346 121118540 195 + 0.999 0.847 -0.575
ENSG00000119397 E032 0.6731895 0.042181352 0.750154741   9 121121793 121121795 3 + 0.224 0.166 -0.539
ENSG00000119397 E033 0.9466924 0.015831065 0.981077313   9 121121796 121121808 13 + 0.278 0.285 0.046
ENSG00000119397 E034 2.7050274 0.027263065 0.187365810 0.413556329 9 121121809 121121875 67 + 0.617 0.379 -1.172
ENSG00000119397 E035 3.7057325 0.078243284 0.504063869 0.703659718 9 121121876 121121951 76 + 0.700 0.574 -0.546
ENSG00000119397 E036 0.2922838 0.027607787 0.599987774   9 121122395 121122426 32 + 0.088 0.165 1.044
ENSG00000119397 E037 18.7299926 0.002143089 0.331972845 0.570810040 9 121123931 121124084 154 + 1.302 1.224 -0.275
ENSG00000119397 E038 22.4127178 0.025539348 0.344679862 0.582219678 9 121125716 121125936 221 + 1.381 1.277 -0.360
ENSG00000119397 E039 16.6031131 0.002070379 0.665192906 0.813160393 9 121135806 121135982 177 + 1.234 1.200 -0.123
ENSG00000119397 E040 14.1972166 0.031990809 0.944310719 0.974488219 9 121138545 121138661 117 + 1.163 1.165 0.008
ENSG00000119397 E041 7.2745511 0.076748939 0.804598949 0.898974015 9 121138662 121138679 18 + 0.881 0.936 0.210
ENSG00000119397 E042 16.8498315 0.002591111 0.573374744 0.752554485 9 121140641 121140786 146 + 1.246 1.199 -0.164
ENSG00000119397 E043 11.4701404 0.005106575 0.480676279 0.687542747 9 121141381 121141429 49 + 1.102 1.031 -0.260
ENSG00000119397 E044 17.5196426 0.001883698 0.073607218 0.231970580 9 121141430 121141588 159 + 1.288 1.131 -0.555
ENSG00000119397 E045 16.4414325 0.001933114 0.002925208 0.022951396 9 121142091 121142270 180 + 1.293 1.012 -1.006
ENSG00000119397 E046 13.6554172 0.003718769 0.001860516 0.016126906 9 121143903 121144052 150 + 1.229 0.900 -1.197
ENSG00000119397 E047 8.3272482 0.004956659 0.135390678 0.340391891 9 121144053 121144082 30 + 0.999 0.817 -0.691
ENSG00000119397 E048 0.3337900 0.028867880 0.598855107   9 121144083 121144242 160 + 0.088 0.166 1.048
ENSG00000119397 E049 14.6258422 0.002629006 0.791290292 0.891203916 9 121144843 121144959 117 + 1.180 1.159 -0.075
ENSG00000119397 E050 16.8367665 0.007012156 0.625164135 0.787433147 9 121145244 121145385 142 + 1.245 1.200 -0.160
ENSG00000119397 E051 16.8975677 0.008828686 0.309939115 0.550423424 9 121146108 121146256 149 + 1.261 1.160 -0.355
ENSG00000119397 E052 5.0433050 0.171408679 0.554223249 0.739290830 9 121146257 121148671 2415 + 0.775 0.719 -0.226
ENSG00000119397 E053 16.2604402 0.025289904 0.581263791 0.757981731 9 121148672 121148861 190 + 1.197 1.248 0.183
ENSG00000119397 E054 10.6764715 0.008557544 0.268497958 0.508176232 9 121150170 121150305 136 + 1.008 1.130 0.440
ENSG00000119397 E055 11.4852104 0.002694257 0.926080128 0.965146798 9 121150306 121150483 178 + 1.071 1.084 0.047
ENSG00000119397 E056 0.1308682 0.031086890 0.236337876   9 121150484 121150654 171 + 0.000 0.165 13.469
ENSG00000119397 E057 0.3337900 0.028867880 0.598855107   9 121152043 121152484 442 + 0.088 0.166 1.048
ENSG00000119397 E058 12.4445791 0.002612957 0.853459582 0.926844833 9 121152485 121152693 209 + 1.095 1.116 0.076
ENSG00000119397 E059 11.3645160 0.002713335 0.573271739 0.752514375 9 121154721 121154815 95 + 1.087 1.031 -0.204
ENSG00000119397 E060 13.2774878 0.004828214 0.307996813 0.548620635 9 121154816 121154913 98 + 1.154 1.050 -0.374
ENSG00000119397 E061 0.0000000       9 121157458 121157469 12 +      
ENSG00000119397 E062 11.0740201 0.007520531 0.401062369 0.629142868 9 121157470 121157509 40 + 1.086 0.993 -0.343
ENSG00000119397 E063 13.1676160 0.002445334 0.666497699 0.813997900 9 121157510 121157600 91 + 1.140 1.100 -0.142
ENSG00000119397 E064 1.1819427 0.406065608 0.342402219   9 121157601 121157739 139 + 0.229 0.456 1.417
ENSG00000119397 E065 9.2501431 0.003399492 0.714762411 0.844778218 9 121157740 121157749 10 + 0.969 1.012 0.160
ENSG00000119397 E066 18.5439107 0.002379199 0.757516129 0.871144527 9 121157750 121157880 131 + 1.272 1.248 -0.085
ENSG00000119397 E067 1.1465935 0.049056088 0.215047025   9 121157881 121157963 83 + 0.224 0.456 1.461
ENSG00000119397 E068 0.4929928 0.021768165 1.000000000   9 121157964 121157982 19 + 0.161 0.166 0.048
ENSG00000119397 E069 15.3017591 0.014872989 0.788941057 0.889862298 9 121157983 121158109 127 + 1.200 1.171 -0.101
ENSG00000119397 E070 0.9817812 0.196569872 0.040810427   9 121158110 121158585 476 + 0.088 0.523 3.375
ENSG00000119397 E071 0.8211734 0.244483017 0.354628263   9 121158586 121158854 269 + 0.160 0.383 1.664
ENSG00000119397 E072 21.7215771 0.002641579 0.239899592 0.476530148 9 121158855 121159019 165 + 1.298 1.392 0.326
ENSG00000119397 E073 7.6804472 0.004580623 0.630538489 0.790783087 9 121160143 121160147 5 + 0.889 0.949 0.227
ENSG00000119397 E074 20.3645781 0.002068174 0.115096228 0.307625520 9 121160148 121160302 155 + 1.257 1.383 0.442
ENSG00000119397 E075 0.3206185 0.024441170 0.488817976   9 121161283 121161505 223 + 0.161 0.000 -12.458
ENSG00000119397 E076 0.3088520 0.026996259 0.599116277   9 121161533 121161625 93 + 0.088 0.165 1.043
ENSG00000119397 E077 21.0730671 0.001936792 0.332290778 0.571089673 9 121161856 121161971 116 + 1.288 1.367 0.274
ENSG00000119397 E078 0.0000000       9 121161972 121162053 82 +      
ENSG00000119397 E079 29.5177017 0.001647951 0.376332991 0.609278752 9 121162054 121162271 218 + 1.443 1.505 0.216
ENSG00000119397 E080 12.9320460 0.007364707 0.537556282 0.727356616 9 121164943 121164995 53 + 1.103 1.172 0.244
ENSG00000119397 E081 17.8353169 0.003034129 0.873106916 0.937666586 9 121164996 121165100 105 + 1.251 1.269 0.062
ENSG00000119397 E082 0.0000000       9 121165101 121165109 9 +      
ENSG00000119397 E083 18.6303188 0.001959878 0.962793356 0.983373064 9 121166107 121166180 74 + 1.272 1.280 0.027
ENSG00000119397 E084 0.1723744 0.031727462 0.235807756   9 121167464 121167488 25 + 0.000 0.166 13.473
ENSG00000119397 E085 33.6694833 0.001498354 0.903927552 0.953858217 9 121167489 121167677 189 + 1.517 1.512 -0.014
ENSG00000119397 E086 29.4661599 0.001770621 0.655017098 0.806720372 9 121168096 121168290 195 + 1.453 1.487 0.116
ENSG00000119397 E087 12.6466956 0.002695983 0.187898805 0.414285847 9 121168291 121168321 31 + 1.071 1.199 0.462
ENSG00000119397 E088 24.5201682 0.001669074 0.124141788 0.322288241 9 121169611 121169816 206 + 1.340 1.453 0.392
ENSG00000119397 E089 1.6140848 0.012198908 0.271313772 0.511277644 9 121169817 121169925 109 + 0.327 0.521 1.047
ENSG00000119397 E090 3.6405169 0.006615095 0.489339778 0.693554511 9 121170549 121171005 457 + 0.683 0.578 -0.457
ENSG00000119397 E091 2.2976358 0.009683661 0.357383480 0.593598985 9 121171006 121171158 153 + 0.540 0.379 -0.825
ENSG00000119397 E092 1.8130289 0.011825741 0.066765874 0.217819591 9 121171159 121171203 45 + 0.511 0.166 -2.276
ENSG00000119397 E093 1.2956455 0.013933906 0.192298738   9 121171204 121171231 28 + 0.410 0.166 -1.760
ENSG00000119397 E094 2.7904410 0.008196373 0.774744707 0.881602466 9 121171232 121171407 176 + 0.567 0.521 -0.214
ENSG00000119397 E095 11.2942179 0.013076047 0.443438617 0.661014494 9 121171408 121171548 141 + 1.029 1.117 0.320
ENSG00000119397 E096 10.5023407 0.029193364 0.308386250 0.549013825 9 121171549 121173242 1694 + 0.987 1.120 0.485
ENSG00000119397 E097 32.0509730 0.004074057 0.320297355 0.559978609 9 121173243 121173509 267 + 1.467 1.537 0.239
ENSG00000119397 E098 0.8214337 0.017737414 0.096154414   9 121173510 121173674 165 + 0.327 0.000 -13.766
ENSG00000119397 E099 16.5428212 0.003229555 0.232991616 0.468585210 9 121173675 121173737 63 + 1.174 1.281 0.378
ENSG00000119397 E100 9.1269021 0.037888639 0.773737506 0.880959362 9 121173738 121175017 1280 + 0.962 1.011 0.184
ENSG00000119397 E101 27.8863045 0.028150999 0.037480401 0.148255050 9 121175018 121175224 207 + 1.353 1.556 0.700
ENSG00000119397 E102 3.2490572 0.180775620 0.856880312 0.928756877 9 121175225 121176915 1691 + 0.567 0.678 0.482
ENSG00000119397 E103 29.1208185 0.007716375 0.000200707 0.002683375 9 121177163 121177774 612 + 1.340 1.618 0.956