ENSG00000119314

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343327 ENSG00000119314 HEK293_OSMI2_6hA HEK293_TMG_6hB PTBP3 protein_coding protein_coding 10.19785 3.472984 16.56089 0.9528749 0.8257969 2.250255 0.4773277 0.07306381 1.246525 0.03653191 0.05914998 3.919076 0.03179583 0.01666667 0.07533333 0.05866667 0.03599728 0.001425887 FALSE TRUE
ENST00000374257 ENSG00000119314 HEK293_OSMI2_6hA HEK293_TMG_6hB PTBP3 protein_coding protein_coding 10.19785 3.472984 16.56089 0.9528749 0.8257969 2.250255 8.0469580 3.11319368 13.006697 0.84305468 0.93388551 2.059270 0.85225000 0.89866667 0.78366667 -0.11500000 0.09137885 0.001425887 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000119314 E001 1.189340 0.34269455 0.894723218   9 112217716 112218434 719 - 0.236 0.397 1.049
ENSG00000119314 E002 290.187403 1.48098885 0.314527818 0.55474218 9 112218435 112220087 1653 - 2.212 2.696 1.614
ENSG00000119314 E003 77.863914 0.78145315 0.306419046 0.54705538 9 112220088 112220373 286 - 1.691 2.048 1.205
ENSG00000119314 E004 339.180578 1.59561649 0.499841489 0.70062852 9 112220374 112222244 1871 - 2.342 2.640 0.992
ENSG00000119314 E005 32.829063 0.53329440 0.343323927 0.58099991 9 112222245 112222354 110 - 1.331 1.671 1.169
ENSG00000119314 E006 81.444122 0.80958819 0.378551702 0.61100981 9 112222355 112222660 306 - 1.731 2.018 0.967
ENSG00000119314 E007 151.169388 0.92845388 0.482098257 0.68848695 9 112222661 112223983 1323 - 2.014 2.238 0.750
ENSG00000119314 E008 59.177158 0.00664414 0.108203884 0.29603741 9 112224133 112224210 78 - 1.651 1.722 0.240
ENSG00000119314 E009 112.315050 0.03617130 0.013150912 0.07105072 9 112227411 112227627 217 - 1.938 1.909 -0.097
ENSG00000119314 E010 73.082286 0.07245111 0.015340325 0.07935484 9 112228380 112228472 93 - 1.768 1.650 -0.398
ENSG00000119314 E011 48.301795 0.07122144 0.008224439 0.05035871 9 112231380 112231413 34 - 1.600 1.418 -0.622
ENSG00000119314 E012 80.977296 0.07605118 0.112747895 0.30373972 9 112232099 112232238 140 - 1.797 1.777 -0.066
ENSG00000119314 E013 58.691730 0.05999931 0.240507638 0.47714761 9 112234820 112234897 78 - 1.649 1.691 0.141
ENSG00000119314 E014 65.956901 0.08338778 0.175718513 0.39807166 9 112250929 112251103 175 - 1.707 1.699 -0.030
ENSG00000119314 E015 48.129470 0.06890618 0.032924302 0.13585965 9 112252678 112252788 111 - 1.589 1.493 -0.330
ENSG00000119314 E016 45.477465 0.05870497 0.042395587 0.16097091 9 112262435 112262504 70 - 1.558 1.511 -0.162
ENSG00000119314 E017 57.099108 0.05858876 0.063779033 0.21119522 9 112262505 112262599 95 - 1.649 1.629 -0.068
ENSG00000119314 E018 73.415440 0.05884208 0.085046769 0.25469787 9 112268049 112268195 147 - 1.751 1.757 0.019
ENSG00000119314 E019 35.315121 0.07475629 0.037797431 0.14907158 9 112275844 112275909 66 - 1.460 1.348 -0.386
ENSG00000119314 E020 39.830455 0.05529758 0.044234977 0.16569870 9 112275910 112276013 104 - 1.502 1.448 -0.185
ENSG00000119314 E021 19.245656 0.05466092 0.285224746 0.52580543 9 112297832 112297840 9 - 1.180 1.241 0.214
ENSG00000119314 E022 55.983363 0.05854492 0.218722237 0.45186638 9 112297841 112297916 76 - 1.625 1.691 0.223
ENSG00000119314 E023 1.755314 0.01164115 0.779584472 0.88446063 9 112330441 112330474 34 - 0.335 0.498 0.885
ENSG00000119314 E024 1.903559 0.01397155 0.556947905 0.74113527 9 112332784 112333029 246 - 0.390 0.386 -0.022
ENSG00000119314 E025 41.997282 0.10228602 0.234259522 0.47002264 9 112333470 112333664 195 - 1.515 1.520 0.018